| First Author | Freichel M | Year | 1998 |
| Journal | FEBS Lett | Volume | 422 |
| Issue | 3 | Pages | 354-8 |
| PubMed ID | 9498815 | Mgi Jnum | J:45886 |
| Mgi Id | MGI:1196666 | Doi | 10.1016/s0014-5793(98)00041-6 |
| Citation | Freichel M, et al. (1998) Alternative splicing and tissue specific expression of the 5' truncated bCCE 1 variant bCCE 1delta514. FEBS Lett 422(3):354-8 |
| abstractText | In many non-excitable as well as electrically excitable cells, depletion of intracellular Ca2+ stores after stimulation of G protein coupled receptors or receptor tyrosine kinases is followed by Ca2+ entry across the plasma membrane, a mechanism referred to as capacitative calcium entry (CCE) [Putney, J.W., Cell Calcium 11 (1990) 611-624; Fasolato, C. et al., Trends Pharmacol Sci. 15 (1994) 77-83]. Recently, we reported that bCCE 1, a homologue of the Drosophila protein trp, exhibits the characteristics of CCE channels [Philipp, S. et al., EMBO J. 15 (1996) 6166-6171]. In this study, we report the cloning of a 5' truncated splice variant (bCCE 1delta514) of the full- length bCCE 1. The bCCE 1delta514 cDNA encodes a protein of 486 amino acids with the ATG triplet encoding M514 of bCCE 1 as translation initiation codon and, therefore, comprises two putative transmembrane segments corresponding to the predicted transmembrane segments 5 and 6 of bCCE 1. bCCE 1delta514 transcripts appear to be specifically expressed in the adrenal gland and genome analysis reveals an alternative splice site within an exon of the CCE 1 gene leading to the formation of bCCE 1delta514. |
