| First Author | Huang MT | Year | 1998 |
| Journal | Carcinogenesis | Volume | 19 |
| Issue | 9 | Pages | 1697-700 |
| PubMed ID | 9771944 | Mgi Jnum | J:49895 |
| Mgi Id | MGI:1289369 | Doi | 10.1093/carcin/19.9.1697 |
| Citation | Huang MT, et al. (1998) Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a] anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis 19(9):1697-700 |
| abstractText | Female Sencar mice (6 weeks old) were administered 1 mg of 7,12- dimethylbenz[a]anthracene (DMBA) by oral gavage once a week for 5 weeks. At 20 weeks after the first dose of DMBA, 68% of mice developed mammary tumors (the average 1.08 tumors per mouse) and 45% had lymphomas/leukemias. Feeding 1% dibenzoylmethane (DBM) in AIN 76A diet, starting at 2 weeks before the first dose of DMBA and continuing until the end of the experiment, inhibited both the multiplicity and incidence of DMBA-induced mammary tumor by 97%. The incidence of lymphomas/leukemias was completely inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little or no effect on the incidence of mammary tumors, and the incidence of lymphomas/leukemias was reduced by 53%. |
