| First Author | Gomez M | Year | 2000 |
| Journal | Nat Immunol | Volume | 1 |
| Issue | 4 | Pages | 348-52 |
| PubMed ID | 11017108 | Mgi Jnum | J:65113 |
| Mgi Id | MGI:1891790 | Doi | 10.1038/79808 |
| Citation | Gomez M, et al. (2000) Control of pre-T cell proliferation and differentiation by the GTPase Rac-I. Nat Immunol 1(4):348-52 |
| abstractText | The GTPase Rac-I has the potential for pleiotropic functions due to its ability to interact with multiple effectors. Here, activation of Rac-I is shown to potently regulate pre-T cell differentiation and proliferation at the point of T cell antigen receptor (TCR) beta selection. An activated Rac-I effector domain mutant that restricts signaling to particular actions on actin dynamics can drive pre-T cell differentiation. Rac-I activation cannot fully substitute for the pre-TCR complex but can fully correct defects in pre-T cell development in mice lacking the adapter molecule Vav-1. The present study identifies the subset of Rac-I responses that mediate Vav-1 action as critical regulators of TCR beta selection. |
