| First Author | Wang L | Year | 2020 |
| Journal | Biochem Biophys Res Commun | Volume | 524 |
| Issue | 4 | Pages | 936-942 |
| PubMed ID | 32057363 | Mgi Jnum | J:327120 |
| Mgi Id | MGI:6712368 | Doi | 10.1016/j.bbrc.2020.01.151 |
| Citation | Wang L, et al. (2020) GSTO1 regulates insulin biosynthesis in pancreatic beta cells. Biochem Biophys Res Commun 524(4):936-942 |
| abstractText | Insulin biosynthesis and secretion by pancreatic beta cells are critical for the maintenance of blood glucose homeostasis. Here, we show that the expression of glutathione S-transferase omega-1 (GSTO1) is upregulated in the primary islet cells of diabetic Goto-Kakizaki (GK) rats. Knocking out GSTO1 upregulated insulin transcripts and increased the insulin content in both INS-1 cells and primary islet cells. In contrast, overexpression of GSTO1 reduced the insulin content. Furthermore, knocking out GSTO1 increased the expression of pancreatic duodenal homeobox-1 (PDX1) at both the transcription and protein levels. These results indicate that GSTO1 may be involved in the regulation of insulin biosynthesis by modulating the transcriptional expression of PDX1. |
