| First Author | Zatka-Haas P | Year | 2021 |
| Journal | Elife | Volume | 10 |
| PubMed ID | 34328419 | Mgi Jnum | J:343922 |
| Mgi Id | MGI:6728706 | Doi | 10.7554/eLife.63163 |
| Citation | Zatka-Haas P, et al. (2021) Sensory coding and the causal impact of mouse cortex in a visual decision. Elife 10:e63163 |
| abstractText | Correlates of sensory stimuli and motor actions are found in multiple cortical areas, but such correlates do not indicate whether these areas are causally relevant to task performance. We trained mice to discriminate visual contrast and report their decision by steering a wheel. Widefield calcium imaging and Neuropixels recordings in cortex revealed stimulus-related activity in visual (VIS) and frontal (MOs) areas, and widespread movement-related activity across the whole dorsal cortex. Optogenetic inactivation biased choices only when targeted at VIS and MOs,proportionally to each site's encoding of the visual stimulus, and at times corresponding to peak stimulus decoding. A neurometric model based on summing and subtracting activity in VIS and MOs successfully described behavioral performance and predicted the effect of optogenetic inactivation. Thus, sensory signals localized in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not play a causal role. |
