| First Author | Yuan X | Year | 2021 |
| Journal | Front Immunol | Volume | 12 |
| Pages | 737658 | PubMed ID | 34721398 |
| Mgi Jnum | J:312706 | Mgi Id | MGI:6785676 |
| Doi | 10.3389/fimmu.2021.737658 | Citation | Yuan X, et al. (2021) Short-Chain Fatty Acids Calibrate RARalpha Activity Regulating Food Sensitization. Front Immunol 12:737658 |
| abstractText | Gut-microbiota dysbiosis links to allergic diseases. The mechanism of the exacerbation of food allergy caused by gut-microbiota dysbiosis remains unknown. Regulation of retinoic acid receptor alpha (RARalpha) signaling is critical for gut immune homeostasis. Here we clarified that RARalpha in dendritic cells (DCs) promotes Th2 cell differentiation. Antibiotics treatment stimulates retinoic acid signaling in mucosal DCs. We found microbiota metabolites short-chain fatty acids (SCFAs) maintain IGF-1 levels in serum and mesenteric lymph nodes. The IGF-1/Akt pathway is essential for regulating the transcription of genes targeted by RARalpha. And RARalpha in DCs affects type I interferon (IFN-I) responses through regulating transcription of IFN-alpha. Our study identifies SCFAs crosstalk with RARalpha in dendritic cells as a critical modulator that plays a core role in promoting Th2 cells differentiation at a state of modified/disturbed microbiome. |
