| First Author | Kim MC | Year | 2021 |
| Journal | Nat Commun | Volume | 12 |
| Issue | 1 | Pages | 5764 |
| PubMed ID | 34599187 | Mgi Jnum | J:313699 |
| Mgi Id | MGI:6787631 | Doi | 10.1038/s41467-021-26091-4 |
| Citation | Kim MC, et al. (2021) CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Nat Commun 12(1):5764 |
| abstractText | Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, using single-cell RNA sequencing of immune cells from renal clear cell carcinoma (ccRCC) patients, we identify two distinct transcriptional fates for TI Treg cells, Fate-1 and Fate-2. The Fate-1 signature is associated with a poorer prognosis in ccRCC and several other solid cancers. CD177, a cell surface protein normally expressed on neutrophil, is specifically expressed on Fate-1 TI Treg cells in several solid cancer types, but not on other TI or peripheral Treg cells. Mechanistically, blocking CD177 reduces the suppressive activity of Treg cells in vitro, while Treg-specific deletion of Cd177 leads to decreased tumor growth and reduced TI Treg frequency in mice. Our results thus uncover a functional CD177(+) TI Treg population that may serve as a target for TI Treg-specific immunotherapy. |
