| First Author | Pyne NJ | Year | 2013 |
| Journal | Cancer Cell | Volume | 23 |
| Issue | 1 | Pages | 5-7 |
| PubMed ID | 23328479 | Mgi Jnum | J:194344 |
| Mgi Id | MGI:5473460 | Doi | 10.1016/j.ccr.2012.12.005 |
| Citation | Pyne NJ, et al. (2013) Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer. Cancer Cell 23(1):5-7 |
| abstractText | In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. This appears critical for progression from chronic inflammation to colon cancer. |
