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Publication : Role of the first round of DNA replication in reprogramming gene expression in the preimplantation mouse embryo.

First Author  Davis W Jr Year  1997
Journal  Mol Reprod Dev Volume  47
Issue  4 Pages  430-4
PubMed ID  9211427 Mgi Jnum  J:41598
Mgi Id  MGI:894095 Citation  Davis W Jr, et al. (1997) Role of the first round of DNA replication in reprogramming gene expression in the preimplantation mouse embryo. Mol Reprod Dev 47(4):430-4
abstractText  The first round of DNA replication has been proposed to provide a window of opportunity for maternally-derived transcription factors to gain access to their cognate cis-binding DNA sequences and thereby reprogram the pattern of gene expression that occurs during the 2-cell stage. Using high-resolution, two-dimensional electrophoresis of metabolically radio-labeled polypeptides, we report the expression of a group of several polypeptides whose synthesis in the 2-cell embryo is due to transcription (i.e., alpha-amanitin-sensitive) and depends on the first round of DNA replication (i.e., aphidicolin-sensitive). We also describe the synthesis of another subset of alpha-amanitin-sensitive polypeptides whose expression does not require the first round of DNA replication (i.e., aphidicolin-insensitive). These results are consistent with the proposed role of the first round of DNA replication in reprogramming the pattern of gene expression.
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