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Publication : Age-related changes in contact photosensitivity differ among mouse strains.

First Author  Brown WR Year  1989
Journal  Mech Ageing Dev Volume  49
Issue  2 Pages  137-46
PubMed ID  2529401 Mgi Jnum  J:22710
Mgi Id  MGI:70569 Citation  Brown WR, et al. (1989) Age-related changes in contact photosensitivity differ among mouse strains. Mech Ageing Dev 49(2):137-46
abstractText  There are differences among mouse strains in the age-related changes in reactivity to the contact photosensitizer tetrachlorosalicylanilide (TCSA). We found a tendency to lower reactions in older mice, with some strains showing declines from an early age (BALB/cJ, MRL/MpJ +/+, MRL/MpJ lpr/lpr and SJL/J). Others had increasing reactions until about 30-50 weeks of age before declining (DBA/1J, C3H/HeJ, and A/J) and one strain (C57BL/6J) had increased reactivity with age. There are also differences in the role of cyclophosphamide-sensitive T-suppressor cells in these age-related changes. In some mouse strains, BALB/cJ, C57BL/6J, A/J, DBA/1J and C3H/HeJ, age-related changes in reactivity to TCSA are independent of changes in cyclophosphamide-sensitive suppressor cells. In other strains, MRL/MpJ +/+, MRL/MpJ lpr/lpr and SJL/J, the development of cyclophosphamide-sensitive suppressor cells is responsible for the initial, though not later, stages of the age-related decline in reactivity.
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