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Publication : Induction of TH1 and TH2 immunity in neonatal mice.

First Author  Forsthuber T Year  1996
Journal  Science Volume  271
Issue  5256 Pages  1728-30
PubMed ID  8596934 Mgi Jnum  J:32136
Mgi Id  MGI:79640 Citation  Forsthuber T, et al. (1996) Induction of TH1 and TH2 immunity in neonatal mice [see comments]. Science 271(5256):1728-30
abstractText  The neonatal period has been thought of as a window in ontogeny, during which the developing immune system is particularly susceptible to tolerization. In the present study, the classic system for induction of neonatal tolerance to protein antigens was reexamined in mice. The presumably tolerogenic protocol was found to trigger a vigorous T helper cell type 2 (TH2) immune response. Thus, neonatal tolerization induces immune deviation, not tolerance in the immunological sense. Neonates are not immune privileged but generate TH2 or TH1 responses, depending on the mode of immunization.
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