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Publication : Transposon-based screens for cancer gene discovery in mouse models.

First Author  Dupuy AJ Year  2010
Journal  Semin Cancer Biol Volume  20
Issue  4 Pages  261-8
PubMed ID  20478384 Mgi Jnum  J:162124
Mgi Id  MGI:4462771 Doi  10.1016/j.semcancer.2010.05.003
Citation  Dupuy AJ (2010) Transposon-based screens for cancer gene discovery in mouse models. Semin Cancer Biol 20(4):261-8
abstractText  Significant emphasis has recently been placed on the characterization of the human cancer genome. This effort has been assisted by the development of new DNA sequencing technologies that allow the genomes of individual tumors to be analyzed in much greater detail. However, the genetic complexity of human cancer has complicated the identification of driver mutations among the more abundant passenger mutations found in tumors. Recently, the Sleeping Beauty (SB) transposon system has been engineered to model cancer in mice. SB-induced tumors are produced by transposon insertional mutagenesis, thus the tagged mutations facilitate the identification of novel cancer genes. This review provides a brief summary of the SB system and its use in modeling cancer in mice.
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