| First Author | Iomhair MM | Year | 1998 |
| Journal | Med Sci Res | Volume | 26 |
| Issue | 7 | Pages | 445-446 |
| Mgi Jnum | J:52660 | Mgi Id | MGI:1329947 |
| Citation | Iomhair MM, et al. (1998) Effect of growth factors on foreign-body sarcoma in the mouse. Med Sci Res 26(7):445-446 |
| abstractText | Many growth factors have been identified and some play a role in neoplastic processes. We investigated the effect of four growth factors-fibroblast growth factor, epidermal growth factor, interleukin-2 and nerve growth factor-on the development of autochthonous sarcoma. Nitrocellulose filters of 25 mm diameter and pore size 0.1 mu m provoked such sarcomas in some 40% of implanted mice. The incidence could be enhanced or inhibited by pre-treating the filters with several of the growth factors. The filters were dipped in the respective growth factor to saturate them before implantation. Four experimental groups of 50 female BALB/c mice, one per growth factor, and one control group of 50, were implanted under anaesthesia and monitored weekly until death. Tumour incidence increased to 53% in both Fibroblast and IL2 (T-cell) growth factor groups, while epidermal and nerve growth factors reduced the tumour yield to 42% and 35% respectively as compared to controls. These results with autochthonous tumours did not show statistically significant tumour inhibition, in contrast to those reported for transplanted tumours. The growth factors may not have remained active long enough to influence the neoplasia. Med Sci Res 26:445-446 (C) 1998 Lippincott-Raven Publishers. |
