| First Author | Jurand A | Year | 1984 |
| Journal | Mouse News Lett | Volume | 70 |
| Pages | 73 | Mgi Jnum | J:24747 |
| Mgi Id | MGI:72475 | Citation | Jurand A (1984) JBT/Jd inbred strain: Teratogenic effects of psychotropic drugs. Mouse News Lett 70:73 |
| abstractText | Full text of MNL contribution: 2. JBT/Jd Inbred strain: Teratogenic effects of psychotropic drugs. This strain has been maintained in our Department since 1965, at present it is at F 83. Its properties are: 1. Free from any spontaneous central nervous system defects. 2. Suffers from a minor inbreeding depression, i.e. about 15% mortality of newborns up to the 3rd week after birth. Inbred strain JBT/Jd is used for experiments on the teratogenic activity and on the teratogenic potential of psychotropic drugs in order to prove or disprove the hypothesis that due to the pharmacological properties of these drugs, i.e. their affinity to the central nervous system (c.n.s.) they are teratogenic for this system if administered at the critical period of gestation during the neural tube closure. Up to now 21 psychotropic drugs have been tested and 17 of them appeared to be teratogenic for the c.n.s. Treatment is applied once in an appropriate dose (teratogenic dose) during the first four hours of the 9th day of pregnancy. The results are scored four days later. The malformations found then are limited exclusively to the c.n.s. (exencephaly, craniorachischisis, kinking of the spinal cord, hydromyeila, brachyuria). Other organs do not show any abnormalities. Out of the drugs examined so far the teratogenic activity of three agonists heroin, methadone hydrochloride and enkephaline analogue FK 33-824, which are themselves very potent teratogens for the c.n.s., was shown to be able to be prevented by pretreatment with an equimolecular dose of nolaxone hydrochloride, which pharmacologically is an antagonist of the opiate narcotic analgesics. (Jurand) |
