Type |
Details |
Score |
Publication |
First Author: |
Dabertrand F |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity. |
Volume: |
118 |
Issue: |
17 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Oka F |
Year: |
2022 |
Journal: |
J Clin Invest |
Title: |
CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis. |
Volume: |
132 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor Notch3/Notch3<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang S |
Year: |
2018 |
Journal: |
PLoS Biol |
Title: |
Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming. |
Volume: |
16 |
Issue: |
9 |
Pages: |
e2005233 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sullivan JP |
Year: |
2010 |
Journal: |
Cancer Res |
Title: |
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. |
Volume: |
70 |
Issue: |
23 |
Pages: |
9937-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugiura K |
Year: |
2023 |
Journal: |
JCI Insight |
Title: |
LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3. |
Volume: |
8 |
Issue: |
14 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2017 |
Journal: |
J Cell Mol Med |
Title: |
Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. |
Volume: |
21 |
Issue: |
9 |
Pages: |
1967-1978 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. |
Volume: |
7 |
Issue: |
37 |
Pages: |
58848-58861 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pradeep CR |
Year: |
2012 |
Journal: |
Oncogene |
Title: |
Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. |
Volume: |
31 |
Issue: |
7 |
Pages: |
907-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gopisetty A |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells. |
Volume: |
190 |
Issue: |
11 |
Pages: |
5516-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klose R |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Loss of the serine protease HTRA1 impairs smooth muscle cells maturation. |
Volume: |
9 |
Issue: |
1 |
Pages: |
18224 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cuervo H |
Year: |
2017 |
Journal: |
Angiogenesis |
Title: |
PDGFRβ-P2A-CreERT2 mice: a genetic tool to target pericytes in angiogenesis. |
Volume: |
20 |
Issue: |
4 |
Pages: |
655-662 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van de Walle I |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength. |
Volume: |
210 |
Issue: |
4 |
Pages: |
683-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zeng H |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. |
Volume: |
6 |
|
Pages: |
20931 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osanyingbemi-Obidi J |
Year: |
2011 |
Journal: |
Mol Cancer Res |
Title: |
Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo. |
Volume: |
9 |
Issue: |
12 |
Pages: |
1746-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Papadakos KS |
Year: |
2019 |
Journal: |
Matrix Biol |
Title: |
Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling. |
Volume: |
81 |
|
Pages: |
107-121 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar P |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling. |
Volume: |
203 |
Issue: |
12 |
Pages: |
3225-3236 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2023 |
Journal: |
FASEB J |
Title: |
Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration. |
Volume: |
37 |
Issue: |
2 |
Pages: |
e22743 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dudley DD |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes. |
Volume: |
4 |
Issue: |
8 |
Pages: |
e6678 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bargo S |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. |
Volume: |
400 |
Issue: |
4 |
Pages: |
606-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang C |
Year: |
2018 |
Journal: |
Cardiovasc Res |
Title: |
Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation. |
Volume: |
114 |
Issue: |
3 |
Pages: |
443-455 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Notch cell surface receptors are large, single-pass type-1 transmembrane proteins found in a diverse range of metazoan species, from human to Caenorhabditis species. The fruit fly, Drosophila melanogaster, possesses only one Notch protein, whereas in C.elegans, two receptors have been found; by contrast, four Notch paralogues (designated N1-4) have been identified in mammals, playing both unique and redundant roles. The hetero-oligomer Notch comprises a large extracellular domain (ECD), containing 10-36 tandem Epidermal Growth Factor (EFG)-like repeats, which are involved in ligand interactions; a negative regulatory region, including three cysteine-rich Lin12-Notch Repeats (LNR); a single trans-membrane domain (TM); a small intracellular domain (ICD), which includes a RAM (RBPjk-association module) domain; six ankyrin repeats (ANK), which are involved in protein-protein interactions; and a PEST domain. Drosophila Notch also contains an OPA domain []. Notch signalling is an evolutionarily conserved pathway involved in a wide variety of developmental processes, including adult homeostasis and stem cell maintenance, cell proliferation and apoptosis []. Notch is activated by a range of ligands -the so-called DSL ligands (Delta/Seratte/LAG-2). Activation is also mediated by a sequence of proteolytic events: ligand binding leads to cleavage of Notch by ADAM proteases []at site 2 (S2) and presenilin-1/g-secretase at sites 3 (S3)and 4 (S4) [].The last cleavage releases the Notch intracellular part of the protein (NICD) from the membrane and, upon release, the NICD translocates to the nucleus where it associates with a CBF1/RBJk/Su(H)/Lag1 (CSL) family of DNA-binding proteins. The subsequent recruitment of a co-activator mastermind like (MAML1) protein []promotes transcriptional activation of Notch target genes: well established Notch targets are the Hes and Hey gene families. Aberrant Notch function and signalling has been associated with a number of human disorders, including Allagile syndrome, spondylocostal dysostosis, aortic valve disease, CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), and T-cell Acute Lympho-blastic Leukemia (T-ALL); it has also been implicated in various human carcinomas [, ]. Notch3 displays a more restrictive distribution than the rest of the Notch subtypes, being expressed predominantly in vascular smooth muscle cells, the central nervous system, certain thymocytes subsets, and in regulatory T cells []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Breikaa RM |
Year: |
2022 |
Journal: |
Vascul Pharmacol |
Title: |
Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. |
Volume: |
145 |
|
Pages: |
107087 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li L |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e71041 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang S |
Year: |
2016 |
Journal: |
Oncogene |
Title: |
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. |
Volume: |
35 |
Issue: |
19 |
Pages: |
2485-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kunze B |
Year: |
2020 |
Journal: |
Gastroenterology |
Title: |
Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma. |
Volume: |
159 |
Issue: |
2 |
Pages: |
575-590 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alexander GM |
Year: |
2022 |
Journal: |
PLoS One |
Title: |
Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease. |
Volume: |
17 |
Issue: |
9 |
Pages: |
e0274615 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andersson ER |
Year: |
2018 |
Journal: |
Gastroenterology |
Title: |
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. |
Volume: |
154 |
Issue: |
4 |
Pages: |
1080-1095 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kopan R |
Year: |
2009 |
Journal: |
Cell |
Title: |
The canonical Notch signaling pathway: unfolding the activation mechanism. |
Volume: |
137 |
Issue: |
2 |
Pages: |
216-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hartmann D |
Year: |
2002 |
Journal: |
Hum Mol Genet |
Title: |
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. |
Volume: |
11 |
Issue: |
21 |
Pages: |
2615-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu L |
Year: |
2000 |
Journal: |
Nat Genet |
Title: |
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. |
Volume: |
26 |
Issue: |
4 |
Pages: |
484-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gridley T |
Year: |
2003 |
Journal: |
Hum Mol Genet |
Title: |
Notch signaling and inherited disease syndromes. |
Volume: |
12 Spec No 1 |
|
Pages: |
R9-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Louvi A |
Year: |
2006 |
Journal: |
Nat Rev Neurosci |
Title: |
Notch signalling in vertebrate neural development. |
Volume: |
7 |
Issue: |
2 |
Pages: |
93-102 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Strooper B |
Year: |
1999 |
Journal: |
Nature |
Title: |
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. |
Volume: |
398 |
Issue: |
6727 |
Pages: |
518-22 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
734
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
156
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
305
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Artavanis-Tsakonas S |
Year: |
1999 |
Journal: |
Science |
Title: |
Notch signaling: cell fate control and signal integration in development. |
Volume: |
284 |
Issue: |
5415 |
Pages: |
770-6 |
|
•
•
•
•
•
|