Type |
Details |
Score |
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2022 |
Journal: |
Front Cell Dev Biol |
Title: |
Rictor maintains endothelial integrity under shear stress. |
Volume: |
10 |
|
Pages: |
963866 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agarwal NK |
Year: |
2013 |
Journal: |
Oncogene |
Title: |
Rictor regulates cell migration by suppressing RhoGDI2. |
Volume: |
32 |
Issue: |
20 |
Pages: |
2521-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gkountakos A |
Year: |
2018 |
Journal: |
Carcinogenesis |
Title: |
Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex. |
|
|
|
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE67077 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo Z |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells. |
Volume: |
418 |
Issue: |
2 |
Pages: |
426-32 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE46515 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Z |
Year: |
2019 |
Journal: |
Int J Biol Sci |
Title: |
Rictor ablation in BMSCs inhibits bone metastasis of TM40D cells by attenuating osteolytic destruction and CAF formation. |
Volume: |
15 |
Issue: |
11 |
Pages: |
2448-2460 |
|
•
•
•
•
•
|
Allele |
Name: |
RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
RPTOR independent companion of MTOR, complex 2; gene trap RRR347, BayGenomics |
Allele Type: |
Gene trapped |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].This domain is the N-terminal conserved section that may include several individual domains. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is found in the more conserved central section of Rictor (rapamycin-insensitive companion of mTOR) that may include several individual domains. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represent the conserved domain 5 of the Rictor (Rapamycin-insensitive companion of mTOR) protein. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the domain 4 of the Rictor (rapamycin-insensitive companion of mTOR) protein. It is found in the more conserved central section that may include several individual domainsThe mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Masri J |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. |
Volume: |
67 |
Issue: |
24 |
Pages: |
11712-20 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Sparks CA |
Year: |
2010 |
Journal: |
Oncogene |
Title: |
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. |
Volume: |
29 |
Issue: |
26 |
Pages: |
3733-44 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
PTM |
Description: |
The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTORC1 and mTORC2, important for nutrient- and growth-factor signalling []. Rictor (rapamycin-insensitive companion of mTOR) is an essential component of the complex mTORC2 []. It appears to serve as a scaffolding protein important for maintaining mTORC2 integrity. Rictor interacts with 14-3-3 in a Thr1135-dependent manner []. Rictor can be inhibited by short-term rapamycin treatment, showing that Thr1135 is an mTORC1-regulated site [].This short region is the phoshorylation site of Rictor. |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rictor/Rictor |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rictor/Rictor |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rictor/Rictor<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
796
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1708
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1157
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee S |
Year: |
2005 |
Journal: |
Mol Biol Cell |
Title: |
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. |
Volume: |
16 |
Issue: |
10 |
Pages: |
4572-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ho HL |
Year: |
2005 |
Journal: |
Curr Genet |
Title: |
Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex. |
Volume: |
47 |
Issue: |
5 |
Pages: |
273-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuo T |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. |
Volume: |
27 |
Issue: |
8 |
Pages: |
3154-64 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Protein pianissimo (PiaA) is a component of the target of rapamycin complex 2 (TORC2) in Dictyostelium []. This complex regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Homologues of PiaA are found in Saccharomyces cerevisiae (TSC11/AVO3) [], Schizosaccaromyces pombe (Ste20) [], and vertebrates, where it is also known as Rictor (rapamycin-insensitive companion of mTOR) [, ].Rictor, together with Sin1, is believed to function as an adaptor protein controlling the mTORC2 substrate binding and specificity. Rictor is known to have a role in cytoskeleton regulation and cell migration [, ]. It is likely that rictor regulates cell morphology and migration by playing a role as the indispensable component of mTORC2 and also by carrying mTORC2-independent functions. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
216
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
308
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
255
|
Fragment?: |
false |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pten/Pten<+> Rictor/Rictor<+> |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Wrobel L |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR. |
Volume: |
33 |
Issue: |
13 |
Pages: |
108564 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu M |
Year: |
2021 |
Journal: |
Science |
Title: |
WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity. |
Volume: |
371 |
Issue: |
6536 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Perkey E |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function. |
Volume: |
191 |
Issue: |
9 |
Pages: |
4648-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee DY |
Year: |
2010 |
Journal: |
Genes Dev |
Title: |
Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner. |
Volume: |
24 |
Issue: |
20 |
Pages: |
2317-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Driscoll DR |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer. |
Volume: |
76 |
Issue: |
23 |
Pages: |
6911-6923 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phung TL |
Year: |
2015 |
Journal: |
Cancer Res |
Title: |
Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth. |
Volume: |
75 |
Issue: |
1 |
Pages: |
40-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim D |
Year: |
2020 |
Journal: |
Immunity |
Title: |
Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism. |
Volume: |
53 |
Issue: |
3 |
Pages: |
581-596.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamano Y |
Year: |
2013 |
Journal: |
FEBS Lett |
Title: |
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. |
Volume: |
587 |
Issue: |
20 |
Pages: |
3303-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun SY |
Year: |
2013 |
Journal: |
Cancer Lett |
Title: |
mTOR kinase inhibitors as potential cancer therapeutic drugs. |
Volume: |
340 |
Issue: |
1 |
Pages: |
1-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Körner A |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A. |
Volume: |
10 |
Issue: |
1 |
Pages: |
633 |
|
•
•
•
•
•
|
Publication |
First Author: |
Serna R |
Year: |
2022 |
Journal: |
iScience |
Title: |
c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity. |
Volume: |
25 |
Issue: |
6 |
Pages: |
104325 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2022 |
Journal: |
Commun Biol |
Title: |
mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling. |
Volume: |
5 |
Issue: |
1 |
Pages: |
726 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wan S |
Year: |
2022 |
Journal: |
Cell Death Dis |
Title: |
mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation. |
Volume: |
13 |
Issue: |
10 |
Pages: |
862 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhar SK |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation. |
Volume: |
294 |
Issue: |
17 |
Pages: |
6831-6842 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ravichandran K |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2. |
Volume: |
23 |
Issue: |
18 |
Pages: |
4919-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang RH |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. |
Volume: |
121 |
Issue: |
11 |
Pages: |
4477-90 |
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Publication |
First Author: |
Völkers M |
Year: |
2013 |
Journal: |
Circulation |
Title: |
Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage. |
Volume: |
128 |
Issue: |
19 |
Pages: |
2132-44 |
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Publication |
First Author: |
Brown J |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1. |
Volume: |
286 |
Issue: |
52 |
Pages: |
44295-305 |
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Publication |
First Author: |
Sane S |
Year: |
2023 |
Journal: |
Oncogene |
Title: |
UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer. |
Volume: |
42 |
Issue: |
21 |
Pages: |
1763-1776 |
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Publication |
First Author: |
Han X |
Year: |
2022 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
Aerobic exercise ameliorates insulin resistance in C57BL/6Â J mice via activating Sestrin3. |
Volume: |
1869 |
Issue: |
1 |
Pages: |
166568 |
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Publication |
First Author: |
Kim EK |
Year: |
2011 |
Journal: |
Oncogene |
Title: |
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis. |
Volume: |
30 |
Issue: |
26 |
Pages: |
2954-63 |
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Publication |
First Author: |
Tripathy S |
Year: |
2013 |
Journal: |
J Lipid Res |
Title: |
Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. |
Volume: |
54 |
Issue: |
1 |
Pages: |
71-84 |
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Publication |
First Author: |
Khanna N |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
XPLN is an endogenous inhibitor of mTORC2. |
Volume: |
110 |
Issue: |
40 |
Pages: |
15979-84 |
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Publication |
First Author: |
Martin TD |
Year: |
2014 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading. |
Volume: |
306 |
Issue: |
12 |
Pages: |
E1397-405 |
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Publication |
First Author: |
He J |
Year: |
2015 |
Journal: |
Exp Cell Res |
Title: |
Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: role of mTORC2/SGK1 pathway. |
Volume: |
331 |
Issue: |
1 |
Pages: |
164-75 |
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Publication |
First Author: |
Koo J |
Year: |
2015 |
Journal: |
Mol Cell Biol |
Title: |
mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation. |
Volume: |
35 |
Issue: |
13 |
Pages: |
2344-55 |
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Publication |
First Author: |
Zheng B |
Year: |
2017 |
Journal: |
Int J Dev Biol |
Title: |
mTORC1 and mTORC2 play different roles in regulating cardiomyocyte differentiation from embryonic stem cells. |
Volume: |
61 |
Issue: |
1-2 |
Pages: |
65-72 |
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Publication |
First Author: |
Yano T |
Year: |
2014 |
Journal: |
Circ Res |
Title: |
Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling. |
Volume: |
114 |
Issue: |
8 |
Pages: |
1268-80 |
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Publication |
First Author: |
Manning JR |
Year: |
2019 |
Journal: |
Biochem J |
Title: |
Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling. |
Volume: |
476 |
Issue: |
12 |
Pages: |
1713-1724 |
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Publication |
First Author: |
Gui Y |
Year: |
2019 |
Journal: |
Cell Death Differ |
Title: |
Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury. |
Volume: |
26 |
Issue: |
12 |
Pages: |
2774-2789 |
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Publication |
First Author: |
Tokumura K |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
mTOR regulates skeletogenesis through canonical and noncanonical pathways. |
Volume: |
533 |
Issue: |
1 |
Pages: |
30-35 |
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Publication |
First Author: |
Breda CNS |
Year: |
2021 |
Journal: |
J Immunol |
Title: |
Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis. |
Volume: |
207 |
Issue: |
2 |
Pages: |
626-639 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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