Type |
Details |
Score |
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
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•
•
|
Publication |
First Author: |
Mehner C |
Year: |
2014 |
Journal: |
Mol Cancer Res |
Title: |
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma. |
Volume: |
12 |
Issue: |
10 |
Pages: |
1430-9 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
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•
•
•
|
Publication |
First Author: |
Liu M |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e71366 |
|
•
•
•
•
•
|
Allele |
Name: |
matrix metallopeptidase 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
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•
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Allele |
Name: |
transgene insertion 9, Carolyn J Sympson |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
•
•
•
•
|
Allele |
Name: |
transgene insertion 5, Carolyn J Sympson |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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•
•
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•
|
Publication |
First Author: |
Alexander CM |
Year: |
1996 |
Journal: |
J Cell Biol |
Title: |
Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene. |
Volume: |
135 |
Issue: |
6 Pt 1 |
Pages: |
1669-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rekdal C |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. |
Volume: |
275 |
Issue: |
51 |
Pages: |
40288-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sjøttem E |
Year: |
2007 |
Journal: |
Nucleic Acids Res |
Title: |
The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. |
Volume: |
35 |
Issue: |
19 |
Pages: |
6648-62 |
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•
•
•
•
|
Publication |
First Author: |
Elvenes J |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP. |
Volume: |
6 |
Issue: |
9 |
Pages: |
e24659 |
|
•
•
•
•
•
|
Publication |
First Author: |
Darvekar S |
Year: |
2012 |
Journal: |
Biochem J |
Title: |
Identification of two independent nucleosome-binding domains in the transcriptional co-activator SPBP. |
Volume: |
442 |
Issue: |
1 |
Pages: |
65-75 |
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•
•
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•
|
Protein Domain |
Type: |
Domain |
Description: |
Thisentry represents the C-terminal ePHD/ADD (ATRX-DNMT3-DNMT3L) domain of transcription factor 20 (TCF-20).The extended plant homeodomain (ePHD) zinc finger is characterised as Cys2HisCys5HisCys2His. TCF-20 (also known as SPBP) is involved in transcriptional activation of the MMP3 (matrix metalloprotease 3) promoter. It is strongly enriched on chromatin in interphase HeLa cells, and displays low nuclear mobility, and has been implicated in Smith-Magenis syndrome and Potocki-Lupski syndrome []. As a chromatin-binding protein, TCF-20 plays a role in the regulation of gene expression. It also functions as a transcriptional co-regulator that enhances or represses the transcriptional activity of certain transcription factors/cofactors, such as specificity protein 1 (Sp1), E twenty-six 1 (Ets1) [], paired box protein 6 (Pax6) [], small nuclear RING-finger (SNURF)/RNF4, c-Jun, androgen receptor (AR) and estrogen receptor alpha (ERalpha) []. TCF-20 contains an N-terminal transactivation domain, a novel DNA-binding domain with an AT-hook motif, three nuclear localization signals (NLSs) and a C-terminal ePHD/ADD domain. |
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Publication |
First Author: |
Murakami T |
Year: |
2022 |
Journal: |
Sci Signal |
Title: |
Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. |
Volume: |
15 |
Issue: |
758 |
Pages: |
eabl5304 |
|
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•
•
•
•
|
Publication |
First Author: |
Popovics P |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
Osteopontin Deficiency Ameliorates Prostatic Fibrosis and Inflammation. |
Volume: |
22 |
Issue: |
22 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thangaraju M |
Year: |
2005 |
Journal: |
Development |
Title: |
C/EBPdelta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution. |
Volume: |
132 |
Issue: |
21 |
Pages: |
4675-85 |
|
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•
•
•
•
|
Publication |
First Author: |
Tsoutsman T |
Year: |
2013 |
Journal: |
J Mol Cell Cardiol |
Title: |
CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. |
Volume: |
62 |
|
Pages: |
164-78 |
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•
•
•
•
|
Publication |
First Author: |
Liou GY |
Year: |
2024 |
Journal: |
Int J Mol Sci |
Title: |
Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases. |
Volume: |
25 |
Issue: |
9 |
|
|
•
•
•
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•
|
Publication |
First Author: |
Cullen AE |
Year: |
2023 |
Journal: |
Cells |
Title: |
AKT Mediates Adiponectin-Dependent Regulation of VSMC Phenotype. |
Volume: |
12 |
Issue: |
20 |
|
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•
•
•
•
|
Publication |
First Author: |
Österreicher CH |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. |
Volume: |
108 |
Issue: |
1 |
Pages: |
308-13 |
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•
•
•
•
|
Publication |
First Author: |
Hoshino A |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts. |
Volume: |
126 |
Issue: |
Pt 4 |
Pages: |
1032-45 |
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•
•
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•
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Publication |
First Author: |
Muhammad K |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
NFAT5 Controls the Integrity of Epidermis. |
Volume: |
12 |
|
Pages: |
780727 |
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•
•
•
•
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Publication |
First Author: |
Erlandsson MC |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function. |
Volume: |
1833 |
Issue: |
12 |
Pages: |
2653-2663 |
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•
•
•
•
|
Publication |
First Author: |
Sweeney SE |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes. |
Volume: |
174 |
Issue: |
10 |
Pages: |
6424-30 |
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•
•
•
•
|
Publication |
First Author: |
Wiera G |
Year: |
2024 |
Journal: |
Sci Rep |
Title: |
Input specificity of NMDA-dependent GABAergic plasticity in the hippocampus. |
Volume: |
14 |
Issue: |
1 |
Pages: |
20463 |
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•
•
•
•
|
Publication |
First Author: |
Georgescu SP |
Year: |
2011 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8. |
Volume: |
301 |
Issue: |
5 |
Pages: |
C1046-56 |
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•
•
•
•
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Publication |
First Author: |
Gatticchi L |
Year: |
2021 |
Journal: |
Biochim Biophys Acta Mol Cell Res |
Title: |
Tm7sf2 gene promotes adipocyte differentiation of mouse embryonic fibroblasts and improves insulin sensitivity. |
Volume: |
1868 |
Issue: |
1 |
Pages: |
118897 |
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•
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Publication |
First Author: |
Smeriglio P |
Year: |
2020 |
Journal: |
Sci Transl Med |
Title: |
Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis. |
Volume: |
12 |
Issue: |
539 |
|
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•
•
•
•
•
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Publication |
First Author: |
Authier H |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors. |
Volume: |
111 |
Issue: |
41 |
Pages: |
14794-9 |
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•
•
•
•
•
|
Publication |
First Author: |
Flannelly J |
Year: |
2002 |
Journal: |
Osteoarthritis Cartilage |
Title: |
Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. |
Volume: |
10 |
Issue: |
9 |
Pages: |
722-33 |
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•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2020 |
Journal: |
Exp Eye Res |
Title: |
Leucine-rich α-2-glycoprotein-1 promotes diabetic corneal epithelial wound healing and nerve regeneration via regulation of matrix metalloproteinases. |
Volume: |
196 |
|
Pages: |
108060 |
|
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•
•
•
•
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Publication |
First Author: |
Joshi PA |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Loss of Alx4, a stromally-restricted homeodomain protein, impairs mammary epithelial morphogenesis. |
Volume: |
297 |
Issue: |
1 |
Pages: |
284-94 |
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•
•
•
•
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Publication |
First Author: |
Harman JL |
Year: |
2019 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling. |
Volume: |
39 |
Issue: |
11 |
Pages: |
2289-2302 |
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•
•
•
•
|
Publication |
First Author: |
Lee SI |
Year: |
2012 |
Journal: |
Arthritis Res Ther |
Title: |
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway. |
Volume: |
14 |
Issue: |
1 |
Pages: |
R38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao YC |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities. |
Volume: |
12 |
|
Pages: |
743030 |
|
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•
•
•
•
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Publication |
First Author: |
Ono M |
Year: |
2018 |
Journal: |
Matrix Biol |
Title: |
CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via α5β1 and TNFα. |
Volume: |
68-69 |
|
Pages: |
533-546 |
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•
•
•
•
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Publication |
First Author: |
Kondo Y |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling. |
Volume: |
8 |
Issue: |
11 |
Pages: |
e81019 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lagosz KB |
Year: |
2020 |
Journal: |
J Dent Res |
Title: |
HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis. |
Volume: |
99 |
Issue: |
1 |
Pages: |
98-106 |
|
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•
•
•
•
|
Publication |
First Author: |
Courties A |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis. |
Volume: |
13 |
|
Pages: |
842538 |
|
•
•
•
•
•
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Publication |
First Author: |
Shu CC |
Year: |
2016 |
Journal: |
Arthritis Rheumatol |
Title: |
Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis. |
Volume: |
68 |
Issue: |
4 |
Pages: |
868-79 |
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1987
 |
Fragment?: |
false |
|
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
419
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1725
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1068
 |
Fragment?: |
true |
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•
•
•
|