Amyloid beta A4 precursor protein-binding family A member 2, also known as Mint2, X11beta, or X11L, is a neuronal adaptor protein that binds to the intracellular domain of the amyloid precursor protein (APP) []. It belongs to the X11/Mint family of adaptor proteins []. It has been shown to modulate processing of APP and accumulation of Abeta (hallmark pathologies of Alzheimer's disease), making it a potential therapeutic target for Alzheimer's disease [, ]. X11beta, as X11alpha, is a important regulator of presynaptic neurotransmitter release [].The X11/Mint family members are multidomain proteins typically composed of a conserved PTB domain and two C-terminal PDZ domains. They are adaptor proteins that possess several functions, such as trafficking and transport, synaptic function and regulation of ion channel []. Two of the family members,X11alpha and X11beta, are expressed primarily in neurones [].
