N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [, ]. This entry represents NDRG3. The function of NDRG3 is not clear. NDRG3 is highly expressed in the testis, ovary, prostate, spinal cord and thymus rudiment []. Its overexpression increases growth rate and migration of the prostate cancer cells and promotes tumour growth in nude mice [].
