Type |
Details |
Score |
Publication |
First Author: |
Lin ME |
Year: |
2016 |
Journal: |
Cardiovasc Res |
Title: |
Runx2 Deletion in Smooth muscle Cells Inhibits Vascular Osteochondrogenesis and Calcification but not Atherosclerotic Lesion Formation. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Maeno T |
Year: |
2011 |
Journal: |
Bone |
Title: |
Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. |
Volume: |
49 |
Issue: |
4 |
Pages: |
673-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida CA |
Year: |
2002 |
Journal: |
Nat Genet |
Title: |
Core-binding factor beta interacts with Runx2 and is required for skeletal development. |
Volume: |
32 |
Issue: |
4 |
Pages: |
633-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hjelmeland AB |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. |
Volume: |
25 |
Issue: |
21 |
Pages: |
9460-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng Q |
Year: |
2003 |
Journal: |
J Cell Biol |
Title: |
Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. |
Volume: |
162 |
Issue: |
5 |
Pages: |
833-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Omatsu Y |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells. |
Volume: |
13 |
Issue: |
1 |
Pages: |
2654 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182667 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6191238 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Runx2 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182667 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6191238 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Runx2 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182667 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6191238 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Runx2 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182667 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6191238 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Runx2 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182667 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191238 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Runx2 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182667 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191238 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Runx2 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182667 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191238 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Runx2 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu X |
Year: |
2020 |
Journal: |
Cancer Res |
Title: |
Runx2 Deficiency in Osteoblasts Promotes Myeloma Progression by Altering the Bone Microenvironment at New Bone Sites. |
Volume: |
80 |
Issue: |
5 |
Pages: |
1036-1048 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwon HJ |
Year: |
2015 |
Journal: |
J Dent Res |
Title: |
Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice. |
Volume: |
94 |
Issue: |
8 |
Pages: |
1113-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGee-Lawrence ME |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice. |
Volume: |
288 |
Issue: |
8 |
Pages: |
5291-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Terry A |
Year: |
2004 |
Journal: |
Gene |
Title: |
Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain. |
Volume: |
336 |
Issue: |
1 |
Pages: |
115-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aberg T |
Year: |
2004 |
Journal: |
Dev Biol |
Title: |
Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. |
Volume: |
270 |
Issue: |
1 |
Pages: |
76-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Owens TW |
Year: |
2014 |
Journal: |
Cancer Res |
Title: |
Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer. |
Volume: |
74 |
Issue: |
18 |
Pages: |
5277-5286 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Q |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
Different Requirements of CBFB and RUNX2 in Skeletal Development among Calvaria, Limbs, Vertebrae and Ribs. |
Volume: |
23 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lin ME |
Year: |
2015 |
Journal: |
Am J Pathol |
Title: |
Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice. |
Volume: |
185 |
Issue: |
7 |
Pages: |
1958-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim KE |
Year: |
2015 |
Journal: |
J Bone Miner Res |
Title: |
Core binding factor β of osteoblasts maintains cortical bone mass via stabilization of Runx2 in mice. |
Volume: |
30 |
Issue: |
4 |
Pages: |
715-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shirai Y |
Year: |
2019 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Runx2 function in cells of neural crest origin during intramembranous ossification. |
Volume: |
509 |
Issue: |
4 |
Pages: |
1028-1033 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teplyuk NM |
Year: |
2009 |
Journal: |
Mol Endocrinol |
Title: |
The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts. |
Volume: |
23 |
Issue: |
6 |
Pages: |
849-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu W |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation. |
Volume: |
292 |
Issue: |
27 |
Pages: |
11178-11188 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka T |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. |
Volume: |
28 |
Issue: |
3 |
Pages: |
1147-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim JI |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Defect in Runx2 gene accelerates ureteral obstruction-induced kidney fibrosis via increased TGF-β signaling pathway. |
Volume: |
1832 |
Issue: |
10 |
Pages: |
1520-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao L |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice. |
Volume: |
7 |
Issue: |
1 |
Pages: |
2371 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2022 |
Journal: |
J Clin Invest |
Title: |
SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease. |
Volume: |
132 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Maruyama Z |
Year: |
2007 |
Journal: |
Dev Dyn |
Title: |
Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. |
Volume: |
236 |
Issue: |
7 |
Pages: |
1876-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang JS |
Year: |
2005 |
Journal: |
EMBO J |
Title: |
Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. |
Volume: |
24 |
Issue: |
14 |
Pages: |
2543-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geng YM |
Year: |
2019 |
Journal: |
Mol Med Rep |
Title: |
LAPTM5 is transactivated by RUNX2 and involved in RANKL trafficking in osteoblastic cells. |
Volume: |
20 |
Issue: |
5 |
Pages: |
4193-4201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schroeder TM |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. |
Volume: |
279 |
Issue: |
40 |
Pages: |
41998-2007 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han MS |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Functional cooperation between vitamin D receptor and Runx2 in vitamin D-induced vascular calcification. |
Volume: |
8 |
Issue: |
12 |
Pages: |
e83584 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao Z |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression. |
Volume: |
281 |
Issue: |
41 |
Pages: |
30884-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Won GW |
Year: |
2019 |
Journal: |
Biochem Biophys Res Commun |
Title: |
MST2 kinase regulates osteoblast differentiation by phosphorylating and inhibiting Runx2 in C2C12 cells. |
Volume: |
512 |
Issue: |
3 |
Pages: |
591-597 |
|
•
•
•
•
•
|
Publication |
First Author: |
He Q |
Year: |
2014 |
Journal: |
J Bone Miner Res |
Title: |
Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity. |
Volume: |
29 |
Issue: |
5 |
Pages: |
1217-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Frutos CA |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. |
Volume: |
28 |
Issue: |
6 |
Pages: |
686-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gross S |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. |
Volume: |
7 |
Issue: |
8 |
Pages: |
e43553 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yen YT |
Year: |
2021 |
Journal: |
Commun Biol |
Title: |
PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. |
Volume: |
4 |
Issue: |
1 |
Pages: |
658 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang S |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. |
Volume: |
286 |
Issue: |
21 |
Pages: |
19149-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaillant F |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection. |
Volume: |
169 |
Issue: |
6 |
Pages: |
2866-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim S |
Year: |
2003 |
Journal: |
Genes Dev |
Title: |
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. |
Volume: |
17 |
Issue: |
16 |
Pages: |
1979-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sawai CM |
Year: |
2013 |
Journal: |
J Exp Med |
Title: |
Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells. |
Volume: |
210 |
Issue: |
11 |
Pages: |
2151-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai Q |
Year: |
2017 |
Journal: |
Cell Death Differ |
Title: |
mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. |
Volume: |
24 |
Issue: |
11 |
Pages: |
1886-1899 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iwamoto M |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The balancing act of transcription factors C-1-1 and Runx2 in articular cartilage development. |
Volume: |
328 |
Issue: |
3 |
Pages: |
777-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2012 |
Journal: |
J Bone Miner Res |
Title: |
Serum response factor regulates bone formation via IGF-1 and Runx2 signals. |
Volume: |
27 |
Issue: |
8 |
Pages: |
1659-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wai PY |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. |
Volume: |
281 |
Issue: |
28 |
Pages: |
18973-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
McDonald L |
Year: |
2014 |
Journal: |
Dis Model Mech |
Title: |
RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. |
Volume: |
7 |
Issue: |
5 |
Pages: |
525-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blyth K |
Year: |
2006 |
Journal: |
Cancer Res |
Title: |
Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. |
Volume: |
66 |
Issue: |
4 |
Pages: |
2195-201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe T |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1003132 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaneki H |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. |
Volume: |
281 |
Issue: |
7 |
Pages: |
4326-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2022 |
Journal: |
Stem Cells |
Title: |
IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation. |
Volume: |
40 |
Issue: |
11 |
Pages: |
1020-1030 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sierra OL |
Year: |
2010 |
Journal: |
Mol Endocrinol |
Title: |
Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3. |
Volume: |
24 |
Issue: |
7 |
Pages: |
1478-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawane T |
Year: |
2014 |
Journal: |
J Bone Miner Res |
Title: |
Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression. |
Volume: |
29 |
Issue: |
9 |
Pages: |
1960-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Z |
Year: |
2020 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm. |
Volume: |
40 |
Issue: |
5 |
Pages: |
1352-1369 |
|
•
•
•
•
•
|
Publication |
First Author: |
Musa RE |
Year: |
2024 |
Journal: |
Development |
Title: |
BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation. |
Volume: |
151 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yan J |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. |
Volume: |
293 |
Issue: |
24 |
Pages: |
9162-9175 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding M |
Year: |
2012 |
Journal: |
J Cell Physiol |
Title: |
Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. |
Volume: |
227 |
Issue: |
10 |
Pages: |
3446-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen H |
Year: |
2014 |
Journal: |
J Bone Miner Res |
Title: |
Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation. |
Volume: |
29 |
Issue: |
12 |
Pages: |
2653-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin R |
Year: |
2023 |
Journal: |
Exp Mol Med |
Title: |
Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis. |
Volume: |
55 |
Issue: |
1 |
Pages: |
69-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang M |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy. |
Volume: |
7 |
Issue: |
1 |
Pages: |
4928 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weng JJ |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Nuclear matrix-targeting of the osteogenic factor Runx2 is essential for its recognition and activation of the alkaline phosphatase gene. |
Volume: |
1830 |
Issue: |
3 |
Pages: |
2839-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang M |
Year: |
2009 |
Journal: |
J Cell Sci |
Title: |
PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation. |
Volume: |
122 |
Issue: |
Pt 9 |
Pages: |
1382-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jang WG |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells. |
Volume: |
404 |
Issue: |
4 |
Pages: |
1004-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGee-Lawrence ME |
Year: |
2014 |
Journal: |
Bone |
Title: |
Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice. |
Volume: |
66 |
|
Pages: |
277-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
James MJ |
Year: |
2006 |
Journal: |
J Bone Miner Res |
Title: |
Different roles of Runx2 during early neural crest-derived bone and tooth development. |
Volume: |
21 |
Issue: |
7 |
Pages: |
1034-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tamiya H |
Year: |
2008 |
Journal: |
Gene |
Title: |
Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator. |
Volume: |
416 |
Issue: |
1-2 |
Pages: |
53-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang JL |
Year: |
2010 |
Journal: |
EMBO Rep |
Title: |
Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing. |
Volume: |
11 |
Issue: |
10 |
Pages: |
765-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirata M |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. |
Volume: |
21 |
Issue: |
5 |
Pages: |
1111-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pratap J |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. |
Volume: |
25 |
Issue: |
19 |
Pages: |
8581-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chou LY |
Year: |
2020 |
Journal: |
Int J Mol Sci |
Title: |
Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38. |
Volume: |
21 |
Issue: |
19 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Reale ME |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
The transcription factor Runx2 is under circadian control in the suprachiasmatic nucleus and functions in the control of rhythmic behavior. |
Volume: |
8 |
Issue: |
1 |
Pages: |
e54317 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sowa AK |
Year: |
2013 |
Journal: |
Am J Pathol |
Title: |
Functional interaction of osteogenic transcription factors Runx2 and Vdr in transcriptional regulation of Opn during soft tissue calcification. |
Volume: |
183 |
Issue: |
1 |
Pages: |
60-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu L |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
Hyperhomocysteinemia induces vascular calcification by activating the transcription factor RUNX2 via Krüppel-like factor 4 up-regulation in mice. |
Volume: |
294 |
Issue: |
51 |
Pages: |
19465-19474 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawane T |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3. |
Volume: |
8 |
Issue: |
1 |
Pages: |
13551 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaes BL |
Year: |
2006 |
Journal: |
Bone |
Title: |
Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation. |
Volume: |
39 |
Issue: |
4 |
Pages: |
724-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qin X |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
Runx2 regulates cranial suture closure by inducing hedgehog, Fgf, Wnt and Pthlh signaling pathway gene expressions in suture mesenchymal cells. |
Volume: |
28 |
Issue: |
6 |
Pages: |
896-911 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cobb AM |
Year: |
2021 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells. |
Volume: |
41 |
Issue: |
4 |
Pages: |
1339-1357 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ge C |
Year: |
2012 |
Journal: |
J Bone Miner Res |
Title: |
Interactions between extracellular signal-regulated kinase 1/2 and p38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity. |
Volume: |
27 |
Issue: |
3 |
Pages: |
538-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ideno H |
Year: |
2020 |
Journal: |
Bone |
Title: |
G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development. |
Volume: |
137 |
|
Pages: |
115332 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cobb J |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. |
Volume: |
103 |
Issue: |
12 |
Pages: |
4511-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SH |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Runx2 protein stabilizes hypoxia-inducible factor-1α through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes. |
Volume: |
287 |
Issue: |
18 |
Pages: |
14760-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyazaki T |
Year: |
2015 |
Journal: |
Cell Tissue Res |
Title: |
Microtubule-associated protein tau (Mapt) is expressed in terminally differentiated odontoblasts and severely down-regulated in morphologically disturbed odontoblasts of Runx2 transgenic mice. |
Volume: |
361 |
Issue: |
2 |
Pages: |
457-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inman CK |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. |
Volume: |
25 |
Issue: |
8 |
Pages: |
3182-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoon WJ |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
Prolyl isomerase Pin1-mediated conformational change and subnuclear focal accumulation of Runx2 are crucial for fibroblast growth factor 2 (FGF2)-induced osteoblast differentiation. |
Volume: |
289 |
Issue: |
13 |
Pages: |
8828-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang XP |
Year: |
2005 |
Journal: |
J Dent Res |
Title: |
Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth. |
Volume: |
84 |
Issue: |
2 |
Pages: |
138-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimura R |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. |
Volume: |
287 |
Issue: |
40 |
Pages: |
33179-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enomoto H |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene. |
Volume: |
278 |
Issue: |
26 |
Pages: |
23971-7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7339043 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7339147 |
Age: |
embryonic day 13.5 |
|
Note: |
Decreased BrdU incorporation was observed by osteogenic cells at the apical edge of the Runx2 expression domain. |
Specimen Label: |
3B |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
106
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Okura H |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. |
Volume: |
9 |
Issue: |
9 |
Pages: |
e108294 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bialek P |
Year: |
2004 |
Journal: |
Dev Cell |
Title: |
A twist code determines the onset of osteoblast differentiation. |
Volume: |
6 |
Issue: |
3 |
Pages: |
423-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagatake T |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. |
Volume: |
10 |
Issue: |
5 |
Pages: |
e0127460 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gustafson JA |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
Calvarial osteoblast gene expression in patients with craniosynostosis leads to novel polygenic mouse model. |
Volume: |
14 |
Issue: |
8 |
Pages: |
e0221402 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Robinson LJ |
Year: |
2023 |
Journal: |
PLoS One |
Title: |
The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1. |
Volume: |
18 |
Issue: |
5 |
Pages: |
e0264596 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zee T |
Year: |
2013 |
Journal: |
FEBS Lett |
Title: |
The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner. |
Volume: |
587 |
Issue: |
6 |
Pages: |
711-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lengner CJ |
Year: |
2002 |
Journal: |
Mech Dev |
Title: |
Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton. |
Volume: |
114 |
Issue: |
1-2 |
Pages: |
167-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. |
Volume: |
108 |
Issue: |
24 |
Pages: |
9863-8 |
|
•
•
•
•
•
|