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Search results 1701 to 1800 out of 1809 for Nedd4

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Type Details Score
Protein Coding Gene
MGP_SPRETEiJ_G0032556 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15314237 | J:92442
First Author: Nassar MA
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.
Volume: 101
Issue: 34
Pages: 12706-11
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Protein
Q3U2D0
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
B1ASF7
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Publication
17287526 | -
First Author: Kota J
Year: 2007
Journal: Genetics
Title: Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae.
Volume: 175
Issue: 4
Pages: 1681-94
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Publication
17167479 | -
First Author: Cox JJ
Year: 2006
Journal: Nature
Title: An SCN9A channelopathy causes congenital inability to experience pain.
Volume: 444
Issue: 7121
Pages: 894-8
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Publication
20635406 | -
First Author: Cox JJ
Year: 2010
Journal: Hum Mutat
Title: Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations.
Volume: 31
Issue: 9
Pages: E1670-86
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Publication
18367543 | -
First Author: Léon S
Year: 2008
Journal: Mol Biol Cell
Title: Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies.
Volume: 19
Issue: 6
Pages: 2379-88
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Protein Domain
IPR028803 | SCN9A
Type: Family
Description: Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [, ].Sodium channel protein type 9 subunit alpha (also known as Nav1.7 or SCN9A) is strongly expressed in nociceptive neurons and plays a role in pain mechanisms, especially in the development of inflammatory pain [, , ]. It interacts with the ubiquitin-protein ligases Nedd4 and Nedd4-2, known to regulate receptors and ion transporters [].
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Protein Domain
IPR035780 | SPRY_Ssh4-like
Type: Domain
Description: This entry represents the SPRY domain found in Ssh4 (suppressor of SHR3 null mutation protein 4) and similar proteins. Ssh4 is a component of the endosome-vacuole trafficking pathway that regulates nutrient transport and may be involved in processes determining whether plasma membrane proteins are degraded or routed to the plasma membrane []. The SPRY domain in Ssh4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. In yeast, Ssh4 and the homologous protein Ear1 (endosomal adapter of RSP5) recruit Rsp5p, an essential ubiquitin ligase of the Nedd4 family, and assist it in its function at multivesicular bodies by directing the ubiquitylation of specific cargoes [].
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Publication
33661101 | J:317347
   
First Author: González-Calvo I
Year: 2021
Journal: Elife
Title: Sushi domain-containing protein 4 controls synaptic plasticity and motor learning.
Volume: 10
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Publication
37659079 | J:340371
First Author: Guo Q
Year: 2023
Journal: Cell Rep
Title: TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation.
Volume: 42
Issue: 9
Pages: 113070
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Publication
23166351 | J:195247
First Author: Han SO
Year: 2012
Journal: J Cell Biol
Title: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.
Volume: 199
Issue: 5
Pages: 817-30
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Publication
32526160 | J:292701
First Author: Alix E
Year: 2020
Journal: Cell Host Microbe
Title: The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Volume: 28
Issue: 1
Pages: 54-68.e7
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Publication
19749746 | J:154022
First Author: Lopez RG
Year: 2009
Journal: Nat Cell Biol
Title: C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.
Volume: 11
Issue: 10
Pages: 1181-90
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Publication
21062905 | J:220439
First Author: McLachlan S
Year: 2011
Journal: Physiol Genomics
Title: In silico QTL mapping of basal liver iron levels in inbred mouse strains.
Volume: 43
Issue: 3
Pages: 136-47
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Protein
Q61168
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q3UD11
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q3TBF2
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q8BFZ0
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q544S4
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q3TBE8
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q3TD09
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
Q6A0D3
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
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Protein
Q3TAZ4
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
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Protein
Q3T982
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
F6WX18
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: true
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Protein
Q3TBQ5
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q3TC76
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
F8WH95
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
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Protein
Q3U6X9
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q3TBK6
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Publication
25092867 | J:224341
First Author: Chen XL
Year: 2014
Journal: Mol Cell Biol
Title: Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.
Volume: 34
Issue: 20
Pages: 3855-66
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Publication
32703111 | J:343053
First Author: Kim T
Year: 2021
Journal: J Cereb Blood Flow Metab
Title: Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Volume: 41
Issue: 5
Pages: 1058-1066
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Publication
20530479 | J:166194
First Author: Gasser A
Year: 2010
Journal: J Biol Chem
Title: Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.
Volume: 285
Issue: 34
Pages: 26149-61
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Publication
32597834 | J:293960
First Author: Bulek K
Year: 2020
Journal: J Clin Invest
Title: Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.
Volume: 130
Issue: 8
Pages: 4218-4234
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Publication
35401828 | J:323199
First Author: Wang X
Year: 2022
Journal: Theranostics
Title: PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex.
Volume: 12
Issue: 6
Pages: 2613-2630
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Publication
28862701 | J:258636
First Author: Henshall TL
Year: 2017
Journal: Cell Death Differ
Title: Deletion of Nedd4-2 results in progressive kidney disease in mice.
Volume: 24
Issue: 12
Pages: 2150-2160
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Publication
26503960 | J:229169
First Author: Kim E
Year: 2016
Journal: Hum Mol Genet
Title: NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.
Volume: 25
Issue: 2
Pages: 211-22
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Publication
28500134 | J:246022
First Author: Zhu W
Year: 2017
Journal: J Biol Chem
Title: The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation.
Volume: 292
Issue: 27
Pages: 11178-11188
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Publication
32165318 | J:299465
First Author: Yin Q
Year: 2020
Journal: Semin Cancer Biol
Title: ITCH as a potential therapeutic target in human cancers.
Volume: 67
Issue: Pt 2
Pages: 117-130
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Publication
29704886 | J:319452
First Author: Chapalamadugu KC
Year: 2018
Journal: Acta Physiol (Oxf)
Title: Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation.
Volume: 224
Issue: 2
Pages: e13083
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Publication
38064504 | J:345911
First Author: Sakurai Y
Year: 2024
Journal: Diabetes
Title: Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass.
Volume: 73
Issue: 3
Pages: 474-489
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Publication
10798388 | -
First Author: Catterall WA
Year: 2000
Journal: Neuron
Title: From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
Volume: 26
Issue: 1
Pages: 13-25
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Publication
16382098 | -
First Author: Catterall WA
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.
Volume: 57
Issue: 4
Pages: 397-409
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Publication
14755250 | -
First Author: Li H
Year: 2004
Journal: Oncogene
Title: An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.
Volume: 23
Issue: 10
Pages: 1801-8
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Publication
19262463 | -
First Author: Jacque E
Year: 2009
Journal: EMBO J
Title: RNF11, a new piece in the A20 puzzle.
Volume: 28
Issue: 5
Pages: 455-6
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Publication
23222715 | -
First Author: Kostaras E
Year: 2013
Journal: Oncogene
Title: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking.
Volume: 32
Issue: 44
Pages: 5220-32
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Publication
25195858 | -
First Author: Santonico E
Year: 2015
Journal: Oncogene
Title: RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.
Volume: 34
Issue: 26
Pages: 3377-90
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Publication
21765415 | J:176472
First Author: Shembade N
Year: 2011
Journal: Nat Immunol
Title: The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Volume: 12
Issue: 9
Pages: 834-43
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Publication
14559117 | -
First Author: Kitching R
Year: 2003
Journal: Biochim Biophys Acta
Title: The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases.
Volume: 1639
Issue: 2
Pages: 104-12
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Publication
14562029 | -
First Author: Subramaniam V
Year: 2003
Journal: Br J Cancer
Title: The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
Volume: 89
Issue: 8
Pages: 1538-44
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Publication
19528490 | -
First Author: Azmi PB
Year: 2009
Journal: Anticancer Res
Title: The RING finger protein11 binds to Smad4 and enhances Smad4-dependant TGF-beta signalling.
Volume: 29
Issue: 6
Pages: 2253-63
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Protein Domain
IPR042981 | RNF11_RING-H2
Type: Domain
Description: RING finger protein 11 (RNF11) is an E3 ubiquitin-protein ligase that acts both as an adaptor and a modulator of itch-mediated control of ubiquitination events underlying membrane traffic. It is the downstream of an enzymatic cascade for the ubiquitination of specific substrates. It is also a molecular adaptor of homologous to E6-associated protein C terminus (HECT)-type ligases []. RNF11 has been implicated in the regulation of several signaling pathways. It enhances the transforming growth factor receptor (TGFR) signaling by both abrogating Smurf2-mediated receptor ubiquitination and by promoting the Smurf2-mediated degradation of AMSH (associated molecule with the SH3 domain of STAM), a de-ubiquitinating enzyme that enhances transforming growth factor-beta (TGF-beta) signalling and epidermal growth factor receptor (EGFR) endosomal recycling [, ]. It also acts directly on Smad4 to enhance Smad4 function, and plays a role in prolonged TGF-beta signalling []. Moreover, RNF11 functions as a critical component of the A20 ubiquitin-editing protein complex that negatively regulates tumor necrosis factor (TNF)-mediated nuclear factor (NF)-kappaB activation []. It also interacts with Smad anchor for receptor activation (SARA) and the endosomal sorting complex required for transport (ESCRT)-0 complex, thus participating in the regulation of lysosomal degradation of EGFR []. Furthermore, RNF11 acts as a novel GGA cargo actively participating in regulating the ubiquitination of the GGA protein family []. In addition, RNF11 functions together with TAX1BP1 to target TANK-binding kinase 1 (TBK1)/IkappaB kinase IKKi, and further restricts antiviral signaling and type I interferon (IFN)-beta production []. RNF11 contains an N-terminal PPPY motif that binds WW domain-containing proteins such as AIP4/itch, Nedd4 and Smurf1/2 (SMAD-specific E3 ubiquitin-protein ligase 1/2), and a C-terminal C3H2C3-type RING-H2 finger that functions as a scaffold for the coordinated transfer of ubiquitin to substrate proteins together with the E2 enzymes UbcH527 and Ubc13.
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Publication
31754701 | J:290126
First Author: Chandrasekaran K
Year: 2019
Journal: Brain
Title: Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy.
Volume: 142
Issue: 12
Pages: 3737-3752
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Publication
37318790 | J:341952
First Author: Zhang YJ
Year: 2023
Journal: FASEB J
Title: Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells: A mechanistic connection between the kidney defects in cpk mice and human ARPKD.
Volume: 37
Issue: 7
Pages: e23008
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Protein
A9JQD6
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Publication
16919471 | J:116586
First Author: Li H
Year: 2006
Journal: Mol Cell Neurosci
Title: Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.
Volume: 33
Issue: 2
Pages: 136-49
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Publication
14651920 | J:86843
First Author: Easterday MC
Year: 2003
Journal: Dev Biol
Title: Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Volume: 264
Issue: 2
Pages: 309-22
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Publication
14595844 | J:86589
First Author: McClive PJ
Year: 2003
Journal: Genesis
Title: Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.
Volume: 37
Issue: 2
Pages: 84-90
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Protein
Q3UQV9
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: true
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Protein
Q62205
Organism: Mus musculus/domesticus
Length: 1984  
Fragment?: false
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Protein
B7ZWN0
Organism: Mus musculus/domesticus
Length: 1984  
Fragment?: false
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Protein
E9PW82
Organism: Mus musculus/domesticus
Length: 1973  
Fragment?: false
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Protein
A0A0R5RP35
Organism: Mus musculus/domesticus
Length: 1932  
Fragment?: false
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Protein
B1AYL0
Organism: Mus musculus/domesticus
Length: 1973  
Fragment?: false
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Protein
F8VPQ7
Organism: Mus musculus/domesticus
Length: 1975  
Fragment?: false
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Protein
A0A0R5RP26
Organism: Mus musculus/domesticus
Length: 1973  
Fragment?: false
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Protein
Z4YLT8
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
B2RY06
Organism: Mus musculus/domesticus
Length: 1973  
Fragment?: false
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Publication
- | J:66661
       
First Author: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Year: 2001
Title: GenBank Record Derived Information
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
19131326 | -
First Author: Sweet SM
Year: 2009
Journal: Mol Cell Proteomics
Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Volume: 8
Issue: 5
Pages: 904-12
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Publication
16452087 | J:263376
First Author: Trinidad JC
Year: 2006
Journal: Mol Cell Proteomics
Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Volume: 5
Issue: 5
Pages: 914-22
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Publication
12477932 | J:82808
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
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Publication
- | J:223507
     
First Author: Li Y
Year: 2015
Journal: MGI Direct Data Submission
Title: Direct data submission for endonuclease mediated alleles from the Institute of Neuroscience, Chinese Academy of Sciences
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
29997285 | J:267911
 
First Author: Timmermans S
Year: 2018
Journal: JCI Insight
Title: Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.
Volume: 3
Issue: 13
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
34815492 | J:314906
First Author: Khang R
Year: 2021
Journal: Sci Rep
Title: Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
Volume: 11
Issue: 1
Pages: 22745
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:104190
     
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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