Actin filament-associated protein 1 (AFAP1, also known as AFAP-110) belongs to the actin-filament associated protein (AFAP) family of adaptor proteins (including AFAP1, AFAP1L1, and AFAP1L2/XB130). AFAP1 functions as an adaptor protein, linking Src kinases and/or other signalling proteins to actin filaments. It can cross-link actin filaments into both network and bundle structures []. AFAP1 contains several protein binding modules, including two pleckstrin homology domains (PH domains), a leucine zipper motif and a target sequence for serine/threonine phosphorylation []. It interacts with actin filaments directly via an actin-binding domain (ABD) located in its C terminus, and through this interaction is involved in the regulation of the cytoskeletal structure []. Its overexpression has been linked to cancers [, ].
