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Search results 6301 to 6400 out of 6491 for App

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Type Details Score
Protein Domain
IPR001108 | Peptidase_A22A
Type: Family
Description: This group of aspartic peptidases belong to MEROPS peptidase family A22 (presenilin family), subfamily A22A, the type example being presenilin 1 from Homo sapiens (Human).Presenilins are polytopic transmembrane (TM) proteins, mutations in whichare associated with the occurrence of early-onset familial Alzheimer'sdisease, a rare form of the disease that results from a single-genemutation [, ]. Alzheimer's disease is associated with the formation of extracellular deposits of amyloid, which contain aggregates of the amyloid-beta peptide. The β-peptides are released from the Alzheimer's amyloid precursor protein (APP) by the action of two peptidase activities: "beta-secretase"cleaves at the N terminus of the peptide, and "gamma-secretase"cleaves at the C terminus. The gamma-secretase cleavage occurs in a transmembrane segment of APP. Presenilin, which exists in a complex with nicastrin, APH-1 and PEN-2, has been identified as gamma-secretase from its deficiency []and mutation of its active site residues [], but proteolytic activity has only been directly demonstrated on a peptide derived from APP [].Presenilin-1 is also known to process notch proteins []and syndecan-3 [].Presenilin has nine transmembrane regions with the active site aspartic acid residues located on TM6, within a Tyr-Asp motif, and TM7, within a Gly-Xaa-Gly-Asp motif []. The protein autoprocesses to form an amino-terminal fragment (TMs 1-6) and a C-terminal fragment (TMs 7-9) []. The tertiary structure of the human gamma-sectretase complex has been solved []. Nicastrin is extracellular, whereas presenilin-1, APH-1 and PEN-2 are all transmembrane proteins. The transmembrane regions of all three proteins form a horseshoe shape.Aspartic peptidases, also known as aspartyl proteases ([intenz:3.4.23.-]), are widely distributed proteolytic enzymes [, , ]known to exist in vertebrates, fungi, plants, protozoa, bacteria, archaea, retroviruses and some plant viruses. All known aspartic peptidases are endopeptidases. A water molecule, activated by two aspartic acid residues, acts as the nucleophile in catalysis. Aspartic peptidases can be grouped into five clans, each of which shows a unique structural fold [].Peptidases in clan AA are either bilobed (family A1 or the pepsin family) or are a homodimer (all other families in the clan, including retropepsin from HIV-1/AIDS) []. Each lobe consists of a single domain with a closed β-barrel and each lobe contributes one Asp to form the active site. Most peptidases in the clan are inhibited by the naturally occurring small-molecule inhibitor pepstatin [].Clan AC contains the single family A8: the signal peptidase 2 family. Members of the family are found in all bacteria. Signal peptidase 2 processes the premurein precursor, removing the signal peptide. The peptidase has four transmembrane domains and the active site is on the periplasmic side of the cell membrane. Cleavage occurs on the amino side of a cysteine where the thiol group has been substituted by a diacylglyceryl group. Site-directed mutagenesis has identified two essential aspartic acid residues which occur in the motifs GNXXDRX and FNXAD (where X is a hydrophobic residue) []. No tertiary structures have been solved for any member of the family, but because of the intramembrane location, the structure is assumed not to be pepsin-like.Clan AD contains two families of transmembrane endopeptidases: A22 and A24. These are also known as "GXGD peptidases"because of a common GXGD motif which includes one of the pair of catalytic aspartic acid residues. Structures are known for members of both families and show a unique, common fold with up to nine transmembrane regions []. The active site aspartic acids are located within a large cavity in the membrane into which water can gain access [].Clan AE contains two families, A25 and A31. Tertiary structures have been solved for members of both families and show a common fold consisting of an α-β-alpha sandwich, in which the beta sheet is five stranded [, ].Clan AF contains the single family A26. Members of the clan are membrane-proteins with a unique fold. Homologues are known only from bacteria. The structure of omptin (also known as OmpT) shows a cylindrical barrel containing ten beta strands inserted in the membrane with the active site residues on the outer surface [].There are two families of aspartic peptidases for which neither structure nor active site residues are known and these are not assigned to clans. Family A5 includes thermopsin, an endopeptidase found only in thermophilic archaea. Family A36 contains sporulation factor SpoIIGA, which is known to process and activate sigma factor E, one of the transcription factors that controls sporulation in bacteria [].
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Publication
8894693 | J:35780
First Author: Bressler SL
Year: 1996
Journal: Hum Mol Genet
Title: cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.
Volume: 5
Issue: 10
Pages: 1589-98
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Publication
38347225 | J:346614
First Author: Yin T
Year: 2024
Journal: EMBO Rep
Title: Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias.
Volume: 25
Issue: 3
Pages: 1326-1360
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Publication
33810510 | J:307755
 
First Author: Poelaert BJ
Year: 2021
Journal: Cancers (Basel)
Title: Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer.
Volume: 13
Issue: 7
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Publication
26868295 | J:246319
First Author: Goldsworthy M
Year: 2016
Journal: Diabetes
Title: Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.
Volume: 65
Issue: 5
Pages: 1434-46
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Publication
23418567 | J:197198
First Author: Garringer HJ
Year: 2013
Journal: PLoS One
Title: Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.
Volume: 8
Issue: 2
Pages: e56426
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Publication
11549720 | J:71536
First Author: Cowan CM
Year: 2001
Journal: J Neurosci
Title: Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons.
Volume: 21
Issue: 18
Pages: 7099-109
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Publication
12082633 | J:76678
First Author: Fleischer A
Year: 2002
Journal: Oncogene
Title: Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2.
Volume: 21
Issue: 20
Pages: 3181-9
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Publication
16899370 | J:113199
First Author: Burgess BL
Year: 2006
Journal: Neurobiol Dis
Title: Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.
Volume: 24
Issue: 1
Pages: 114-27
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Publication
22855807 | J:185792
First Author: Han HJ
Year: 2012
Journal: J Neurosci
Title: Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator.
Volume: 32
Issue: 31
Pages: 10574-86
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Publication
24068166 | J:201811
First Author: Bhutta MF
Year: 2013
Journal: Mamm Genome
Title: Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.
Volume: 24
Issue: 11-12
Pages: 439-45
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Publication
34035282 | J:314716
First Author: Alvarez-Vergara MI
Year: 2021
Journal: Nat Commun
Title: Non-productive angiogenesis disassembles Aß plaque-associated blood vessels.
Volume: 12
Issue: 1
Pages: 3098
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Publication
32776088 | J:332749
First Author: Fowler AJ
Year: 2020
Journal: Hum Mol Genet
Title: Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.
Volume: 29
Issue: 17
Pages: 2882-2898
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Publication
29358916 | J:310530
 
First Author: Yang S
Year: 2017
Journal: Front Aging Neurosci
Title: Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides.
Volume: 9
Pages: 435
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Publication
23175831 | J:192812
First Author: Choi SW
Year: 2012
Journal: J Neurosci
Title: No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease.
Volume: 32
Issue: 47
Pages: 16775-84
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Publication
18256671 | J:132628
First Author: Meyer-Luehmann M
Year: 2008
Journal: Nature
Title: Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Volume: 451
Issue: 7179
Pages: 720-4
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Publication
22367970 | J:183771
First Author: Manczak M
Year: 2012
Journal: Hum Mol Genet
Title: Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.
Volume: 21
Issue: 11
Pages: 2538-47
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Publication
30311654 | J:279358
First Author: Whitesell JD
Year: 2019
Journal: J Comp Neurol
Title: Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease.
Volume: 527
Issue: 13
Pages: 2122-2145
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Publication
27155503 | J:242424
First Author: Hargis KE
Year: 2017
Journal: Behav Brain Res
Title: Transcriptional signatures of brain aging and Alzheimer's disease: What are our rodent models telling us?
Volume: 322
Issue: Pt B
Pages: 311-328
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Publication
26872418 | J:281483
 
First Author: Ferretti MT
Year: 2016
Journal: Brain Behav Immun
Title: T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer's disease-like cerebral amyloidosis.
Volume: 54
Pages: 211-225
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Publication
18516051 | J:137043
First Author: Town T
Year: 2008
Journal: Nat Med
Title: Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
Volume: 14
Issue: 6
Pages: 681-7
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Publication
21235806 | J:194454
First Author: Fonseca MI
Year: 2011
Journal: J Neuroinflammation
Title: Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Volume: 8
Issue: 1
Pages: 4
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Publication
18800967 | J:141307
First Author: Ribe EM
Year: 2008
Journal: Biochem J
Title: Mechanisms of neuronal death in disease: defining the models and the players.
Volume: 415
Issue: 2
Pages: 165-82
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Publication
31235644 | J:283607
First Author: Kubo A
Year: 2019
Journal: J Neurosci
Title: Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain.
Volume: 39
Issue: 34
Pages: 6781-6797
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Publication
33859747 | J:348495
First Author: Wang W
Year: 2021
Journal: Theranostics
Title: A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models.
Volume: 11
Issue: 11
Pages: 5279-5295
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Publication
30120733 | J:285073
First Author: Comerota MM
Year: 2019
Journal: Mol Neurobiol
Title: Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies.
Volume: 56
Issue: 5
Pages: 3341-3355
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Publication
36843263 | J:338361
First Author: Kim SH
Year: 2023
Journal: Autophagy
Title: Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease.
Volume: 19
Issue: 8
Pages: 2318-2337
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Publication
31004063 | J:274643
First Author: Xiang J
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.
Volume: 116
Issue: 18
Pages: 9094-9102
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Publication
37118504 | J:337860
First Author: Dejanovic B
Year: 2022
Journal: Nat Aging
Title: Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models.
Volume: 2
Issue: 9
Pages: 837-850
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Publication
33891876 | J:306299
First Author: Bourdenx M
Year: 2021
Journal: Cell
Title: Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Volume: 184
Issue: 10
Pages: 2696-2714.e25
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Publication
21835156 | J:176301
First Author: Montgomery SL
Year: 2011
Journal: Am J Pathol
Title: Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.
Volume: 179
Issue: 4
Pages: 2053-70
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Publication
28860088 | J:258530
 
First Author: Angulo SL
Year: 2017
Journal: Neurobiol Dis
Title: Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit.
Volume: 108
Pages: 261-276
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Publication
37014740 | J:337878
First Author: Xing Z
Year: 2023
Journal: Hum Mol Genet
Title: Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome.
Volume: 32
Issue: 13
Pages: 2205-2218
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Publication
29024660 | J:253213
First Author: Zhao Y
Year: 2017
Journal: Neuron
Title: Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels.
Volume: 96
Issue: 2
Pages: 355-372.e6
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Publication
21704011 | J:174403
First Author: Medeiros R
Year: 2011
Journal: Am J Pathol
Title: Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.
Volume: 179
Issue: 2
Pages: 980-91
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Publication
27708157 | J:238628
First Author: Reinders NR
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3.
Volume: 113
Issue: 42
Pages: E6526-E6534
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Publication
27421117 | J:252385
First Author: Hansen HH
Year: 2016
Journal: PLoS One
Title: Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease.
Volume: 11
Issue: 7
Pages: e0158205
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Publication
35584626 | J:348528
First Author: Kass B
Year: 2022
Journal: Cell Rep Med
Title: Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo.
Volume: 3
Issue: 5
Pages: 100630
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Publication
18021291 | J:141555
First Author: Lopez JR
Year: 2008
Journal: J Neurochem
Title: Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice.
Volume: 105
Issue: 1
Pages: 262-71
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Publication
24440716 | J:208793
First Author: Sun X
Year: 2014
Journal: Cell Rep
Title: miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models.
Volume: 6
Issue: 2
Pages: 264-70
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Publication
32920368 | J:348446
 
First Author: Danielyan L
Year: 2020
Journal: EBioMedicine
Title: Cell motility and migration as determinants of stem cell efficacy.
Volume: 60
Pages: 102989
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Publication
28814543 | J:250614
 
First Author: Le Pichon CE
Year: 2017
Journal: Sci Transl Med
Title: Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
Volume: 9
Issue: 403
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Publication
30525042 | J:268837
 
First Author: Sabbir MG
Year: 2018
Journal: Front Mol Biosci
Title: Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease.
Volume: 5
Pages: 99
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Publication
20133765 | J:157545
First Author: Bryleva EY
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Volume: 107
Issue: 7
Pages: 3081-6
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Publication
25447943 | J:231418
 
First Author: Hohsfield LA
Year: 2014
Journal: Mol Cell Neurosci
Title: Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models.
Volume: 63
Pages: 83-95
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Publication
25339759 | J:217151
First Author: Shibuya Y
Year: 2014
Journal: J Neurosci
Title: Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
Volume: 34
Issue: 43
Pages: 14484-501
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Publication
30850634 | J:275633
First Author: Caberlotto L
Year: 2019
Journal: Sci Rep
Title: Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases.
Volume: 9
Issue: 1
Pages: 3965
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Publication
36451854 | J:348479
First Author: Yang H
Year: 2022
Journal: Theranostics
Title: Adoptive therapy with amyloid-β specific regulatory T cells alleviates Alzheimer's disease.
Volume: 12
Issue: 18
Pages: 7668-7680
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Publication
20305648 | J:159680
First Author: Fuhrmann M
Year: 2010
Journal: Nat Neurosci
Title: Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
Volume: 13
Issue: 4
Pages: 411-3
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Publication
33192524 | J:313486
 
First Author: Iyaswamy A
Year: 2020
Journal: Front Pharmacol
Title: Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease.
Volume: 11
Pages: 584770
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Publication
30998504 | J:284087
   
First Author: Schill EM
Year: 2019
Journal: JCI Insight
Title: Down syndrome mouse models have an abnormal enteric nervous system.
Volume: 5
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Publication
27195491 | J:231889
First Author: Peiris H
Year: 2016
Journal: PLoS Genet
Title: A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.
Volume: 12
Issue: 5
Pages: e1006033
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Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1 Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/? Tg(Thy1-YFP)HJrs/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Psen1/Psen1 Tg(APPSwe,tauP301L)1Lfa/? Tg(Thy1-YFP)HJrs/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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GO Term
GO:1902960 | negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
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GO Term
GO:1902961 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
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Protein Coding Gene
MGI:2135756 | Hspb8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1352463 | Nr1h2
Type: protein_coding_gene
Organism: mouse, laboratory
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Transgene
MGI:3693207 | Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(APPswe,PSEN1dE9)85Dbo | MGI:3524957
Name: transgene insertion 85, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(CMV-IghvaD11)DCat/? Tg(CMV-IgkvaD11)ACat/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
9791530 | -
First Author: Martin GM
Year: 1998
Journal: Cell Mol Life Sci
Title: Introduction: genetic determinants of mid- and late-life dementias.
Volume: 54
Issue: 9
Pages: 895-6
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Publication
9521418 | -
First Author: Cruts M
Year: 1998
Journal: Hum Mutat
Title: Presenilin mutations in Alzheimer's disease.
Volume: 11
Issue: 3
Pages: 183-90
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Protein
B2RUJ5
Organism: Mus musculus/domesticus
Length: 842  
Fragment?: false
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Protein
Q3UH26
Organism: Mus musculus/domesticus
Length: 843  
Fragment?: false
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
9244438 | J:38472
First Author: Sugino H
Year: 1997
Journal: Genomics
Title: Genomic organization and chromosomal localization of the mouse telencephalin gene, a neuronal member of the ICAM family.
Volume: 43
Issue: 2
Pages: 209-15
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Publication
20945367 | J:341385
First Author: Han C
Year: 2011
Journal: J Cell Physiol
Title: Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
Volume: 226
Issue: 5
Pages: 1186-95
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Publication
10965130 | J:64407
First Author: Gu Z
Year: 2000
Journal: Cytogenet Cell Genet
Title: The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9.
Volume: 89
Issue: 3-4
Pages: 230-3
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Transgene
MGI:3525178 | Tg(APPswe,PSEN1dE9)85Dbo
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Csf1/Csf1
Background: B6C3Fe a/a-Csf1/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ldlr/Ldlr
Background: B6.129S7-Ldlr
Zygosity: hm
Has Mutant Allele: true
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Publication
22163178 | J:183163
First Author: Watts JC
Year: 2011
Journal: PLoS Pathog
Title: Protease-resistant prions selectively decrease Shadoo protein.
Volume: 7
Issue: 11
Pages: e1002382
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Publication
27538963 | J:242664
First Author: Gupta M
Year: 2016
Journal: Mamm Genome
Title: Mouse models of Down syndrome: gene content and consequences.
Volume: 27
Issue: 11-12
Pages: 538-555
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Publication
22126738 | J:196862
First Author: Zhang L
Year: 2012
Journal: Bioeng Bugs
Title: Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.
Volume: 3
Issue: 1
Pages: 8-12
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Publication
21228179 | J:168226
First Author: Roberson ED
Year: 2011
Journal: J Neurosci
Title: Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.
Volume: 31
Issue: 2
Pages: 700-11
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Publication
30050035 | J:264863
First Author: Wei Y
Year: 2018
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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