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Search results 301 to 330 out of 330 for Asf1a

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0.092s

Type

Details

Score

Genotype

Symbol:	Del(10Mcm9-Asf1a)1Byg/Del(10Mcm9-Asf1a)1Byg
Background:	involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Del(10Mcm9-Asf1a)1Byg/+
Background:	involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity:	ht
Has Mutant Allele:	true

•

Strain

MGI:6435790 | C3Fe.129P2-Mcm9<Gt(XG743)Byg>

Attribute String:

congenic, gene trap, mutant strain

•

Genotype

Symbol:	Mcm9/Mcm9
Background:	involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Mcm9/Mcm9
Background:	C3Fe.129P2-Mcm9
Zygosity:	hm
Has Mutant Allele:	true

•

Strain

MGI:6435794 | C3Fe.129-Atm<tm1Led> Mcm9<Gt(XG743)Byg>

Attribute String:

mutant strain, targeted mutation, gene trap, congenic

•

Strain

MGI:6435792 | C3Fe.129-Mcm9<Gt(XG743)Byg> Cdkn1a<tm1Tyj>

Attribute String:

congenic, gene trap, mutant strain, targeted mutation

•

Strain

MGI:6435796 | C3Fe.129P2-Chek2<tm1Mak> Mcm9<Gt(XG743)Byg>

Attribute String:

targeted mutation, mutant strain, gene trap, congenic

•

Strain

MGI:6436260 | C3Fe.Cg-Mcm9<Gt(XG743)Byg> Fancm<Chaos4>

Attribute String:

chemically induced mutation, congenic, gene trap, mutant strain, targeted mutation

•

Genotype

Symbol:	Mcm9/Mcm9
Background:	involves: 129P2/OlaHsd * C3HeB/FeJ
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Cdkn1a/Cdkn1a Mcm9/Mcm9
Background:	C3Fe.129-Mcm9 Cdkn1a
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Atm/Atm Mcm9/Mcm9
Background:	C3Fe.129-Atm Mcm9
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Chek2/Chek2 Mcm9/Mcm9
Background:	C3Fe.129P2-Chek2 Mcm9
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Fancm/Fancm Mcm9/Mcm9
Background:	C3Fe.Cg-Mcm9 Fancm
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

29982651 | J:266233

First Author:	Su L
Year:	2018
Journal:	Nucleic Acids Res
Title:	H2A.Z.1 crosstalk with H3K56-acetylation controls gliogenesis through the transcription of folate receptor.
Volume:	46
Issue:	17
Pages:	8817-8831

•

Publication

23798425 | J:198818

First Author:	Tan Y
Year:	2013
Journal:	Proc Natl Acad Sci U S A
Title:	Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency.
Volume:	110
Issue:	28
Pages:	11493-8

•

Publication

26388201 | J:227662

First Author:	Luo Y
Year:	2015
Journal:	Genesis
Title:	MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.
Volume:	53
Issue:	11
Pages:	678-84

•

Publication

26850882 | J:232804

First Author:	Messiaen S
Year:	2016
Journal:	Reproduction
Title:	Loss of the histone chaperone ASF1B reduces female reproductive capacity in mice.
Volume:	151
Issue:	5
Pages:	477-89

•

Protein Domain

IPR019015 | HIRA_B_motif

Type:

Conserved_site

Description:

The HirA B (Histone regulatory homologue A binding) motif is the essential binding interface between and ASF1a, of approx. 40 residues. It forms an antiparallel β-hairpin that binds perpendicular to the strands of the β-sandwich of ASF1a N-terminal core domain, via β-sheet, salt bridge and van der Waals interactions []. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The HIR complex is composed of HIR1, HIR2, HIR3 and HPC2, and interacts with ASF1. The HIR complex cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.

•

Protein

Q3TTG3

Organism:	Mus musculus/domesticus
Length:	181
Fragment?:	true

•

Publication

16980972 | -

First Author:	Tang Y
Year:	2006
Journal:	Nat Struct Mol Biol
Title:	Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.
Volume:	13
Issue:	10
Pages:	921-9

•

Protein

O55047

Organism:	Mus musculus/domesticus
Length:	718
Fragment?:	false

•

Protein

Q6NZC4

Organism:	Mus musculus/domesticus
Length:	657
Fragment?:	true

•

Protein

B7ZC85

Organism:	Mus musculus/domesticus
Length:	633
Fragment?:	false

•

Protein

B1ASU9

Organism:	Mus musculus/domesticus
Length:	750
Fragment?:	false

•

Protein

P70320

Organism:	Mus musculus/domesticus
Length:	482
Fragment?:	false

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

•

Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

•

Publication

12520002 | J:91812

First Author:	Stryke D
Year:	2003
Journal:	Nucleic Acids Res
Title:	BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume:	31
Issue:	1
Pages:	278-81

•

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