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Search results 2301 to 2395 out of 2395 for Pax7

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Type Details Score
Publication
22069237 | J:190192
First Author: Mourikis P
Year: 2012
Journal: Stem Cells
Title: A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state.
Volume: 30
Issue: 2
Pages: 243-52
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Publication
38056454 | J:359738
First Author: Guardiola O
Year: 2023
Journal: Dev Cell
Title: CRIPTO-based micro-heterogeneity of mouse muscle satellite cells enables adaptive response to regenerative microenvironment.
Volume: 58
Issue: 24
Pages: 2896-2913.e6
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pax7/Pax7
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kdm6a/? Pax7/Pax7<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/? Pax7/Pax7<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pax7/Pax7<+>
Background: involves:129S1/Sv * 129S6/SvEv * 129X1/SvJ * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
24466085 | J:212562
First Author: McDonald AA
Year: 2014
Journal: PLoS One
Title: Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice.
Volume: 9
Issue: 1
Pages: e86424
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Publication
31724771 | J:324427
First Author: Welc SS
Year: 2020
Journal: Exp Physiol
Title: Modulation of Klotho expression in injured muscle perturbs Wnt signalling and influences the rate of muscle growth.
Volume: 105
Issue: 1
Pages: 132-147
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Publication
23438940 | J:199548
First Author: Wang G
Year: 2013
Journal: Exp Cell Res
Title: Slit/Robo1 signaling regulates neural tube development by balancing neuroepithelial cell proliferation and differentiation.
Volume: 319
Issue: 8
Pages: 1083-93
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Publication
23642367 | J:317950
First Author: Chan SS
Year: 2013
Journal: Cell Stem Cell
Title: Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner.
Volume: 12
Issue: 5
Pages: 587-601
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Publication
26503169 | J:227915
 
First Author: Le Roux I
Year: 2015
Journal: Nat Commun
Title: Numb is required to prevent p53-dependent senescence following skeletal muscle injury.
Volume: 6
Pages: 8528
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Publication
31266969 | J:345497
First Author: Mohiuddin M
Year: 2019
Journal: Sci Rep
Title: Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit, Myonuclear-, and Mitochondrial-Domains.
Volume: 9
Issue: 1
Pages: 9551
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Publication
33116312 | J:300304
First Author: Shang M
Year: 2020
Journal: Nature
Title: Macrophage-derived glutamine boosts satellite cells and muscle regeneration.
Volume: 587
Issue: 7835
Pages: 626-631
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Publication
37377453 | J:356203
 
First Author: Manickam R
Year: 2023
Journal: Front Aging
Title: Genetic deletion of Kvβ2 (AKR6) causes loss of muscle function and increased inflammation in mice.
Volume: 4
Pages: 1175510
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Protein Domain
IPR001523 | Paired_dom
Type: Domain
Description: The paired domain is an approximately 126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis. The domain was originally described as the 'paired box' in the Drosophila protein paired (prd) [, ]. The paired domain is generally located in the N-terminal part. An octapeptide []and/or a homeodomain can occur C-terminal to the paired domain, as well as a Pro-Ser-Thr-rich C terminus.Paired domain proteins can function as transcription repressors or activators. The paired domain contains three subdomains, which show functional differences in DNA-binding. The crystal structures of prd and Pax proteins show that the DNA-bound paired domain is bipartite, consisting of an N-terminal subdomain (PAI or NTD) and a C-terminal subdomain (RED or CTD), connected by a linker. PAI and RED each form a three-helical fold, with the most C-terminal helices comprising a helix-turn-helix (HTH) motif that binds the DNA major groove. In addition, the PAI subdomain encompasses an N-terminal β-turn andβ-hairpin, also named 'wing', participating in DNA-binding. The linker canbind into the DNA minor groove. Different Pax proteins and their alternativelyspliced isoforms use different (sub)domains for DNA-binding to mediate thespecificity of sequence recognition [, ].Some proteins known to contain a paired domain:Drosophila paired (prd), a segmentation pair-rule class protein.Drosophila gooseberry proximal (gsb-p) and gooseberry distal (gsb-d),segmentation polarity class proteins.Drosophila Pox-meso and Pox-neuro proteins.The Pax proteins:Mammalian protein Pax1, which may play a role in the formation of segmented structures in the embryo. In mouse, mutations in Pax1 produce the undulated phenotype, characterised by vertebral malformations along the entire rostro-caudal axis.Mammalian protein Pax2, a probable transcription factor that may have arole in kidney cell differentiation.Mammalian protein Pax3. Pax3 is expressed during early neurogenesis. In humans, defects in Pax3 are the cause of Waardenburg's syndrome (WS), anautosomal dominant combination of deafness and pigmentary disturbance.Mammalian protein Pax4 pays an important role in the differentiation and development of pancreatic islet beta cells. It binds to a common element in the glucagon, insulin and somatostatin promoters. In humans, it has been related to the rare, familial, clinically and genetically heterogeneous form of diabetes MODY (maturity-onset diabetes of the young).Mammalian protein Pax5, also known as B-cell specific transcription factor(BSAP). Pax5 is involved in the regulation of the CD19 gene. It plays animportant role in B-cell differentiation as well as neural development andspermatogenesis.Mammalian protein Pax6 (oculorhombin). Pax6 is a transcription factor withimportant functions in eye and nasal development. In Man, defects in Pax6are the cause of aniridia type II (AN2), an autosomal dominant disordercharacterised by complete or partial absence of the iris.Mammalian protein Pax7 is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.Mammalian protein Pax8, required in thyroid development.Mammalian protein Pax9, required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. In man, defects in Pax9 cause oligodontia.Zebrafish protein Paired box protein Pax-2a, involved in the development of the midbrain/hindbrain boundary organizer and specification of neuronal cell fates.Xenopus laevis protein Paired box protein Pax-3-A, which promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border.
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Publication
18198335 | J:130251
First Author: Hori K
Year: 2008
Journal: Genes Dev
Title: A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Volume: 22
Issue: 2
Pages: 166-78
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Publication
10811620 | -
First Author: Eberhard D
Year: 2000
Journal: EMBO J
Title: Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.
Volume: 19
Issue: 10
Pages: 2292-303
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Protein
Q9EQ02
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: true
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Protein
Q8VDB6
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
A2A409
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
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Protein
G3UY80
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: true
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Protein
Q8VHH9
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
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Protein
Q8VBY9
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
G3UYK4
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: true
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Protein
Q8VDB4
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: false
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Protein
Q8VBZ1
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
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Publication
2877747 | -
First Author: Bopp D
Year: 1986
Journal: Cell
Title: Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila.
Volume: 47
Issue: 6
Pages: 1033-40
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Publication
3123319 | -
First Author: Baumgartner S
Year: 1987
Journal: Genes Dev
Title: Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.
Volume: 1
Issue: 10
Pages: 1247-67
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Publication
11103953 | -
First Author: Underhill DA
Year: 2000
Journal: Biochem Cell Biol
Title: Genetic and biochemical diversity in the Pax gene family.
Volume: 78
Issue: 5
Pages: 629-38
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Publication
15148315 | -
First Author: Apuzzo S
Year: 2004
Journal: J Biol Chem
Title: Cross-talk between the paired domain and the homeodomain of Pax3: DNA binding by each domain causes a structural change in the other domain, supporting interdependence for DNA Binding.
Volume: 279
Issue: 32
Pages: 33601-12
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Publication
28017795 | J:253889
First Author: Chiche A
Year: 2017
Journal: Cell Stem Cell
Title: Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle.
Volume: 20
Issue: 3
Pages: 407-414.e4
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Publication
31328806 | J:280923
First Author: Feng X
Year: 2019
Journal: EMBO J
Title: Dual function of VGLL4 in muscle regeneration.
Volume: 38
Issue: 17
Pages: e101051
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
12466855 | J:80501
First Author: Gitton Y
Year: 2002
Journal: Nature
Title: A gene expression map of human chromosome 21 orthologues in the mouse.
Volume: 420
Issue: 6915
Pages: 586-90
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Publication
12466854 | J:80502
First Author: Reymond A
Year: 2002
Journal: Nature
Title: Human chromosome 21 gene expression atlas in the mouse.
Volume: 420
Issue: 6915
Pages: 582-6
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Protein
P09084
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q02650
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
P32114
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q00288
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
P47242
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
G3UZ86
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
Q548R5
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
Q8K4Q1
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
A2AIU8
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
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Protein
Q8BS81
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
G3X8Q7
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
G3UXF6
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
Q8K4Q2
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Protein
A2AIU7
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: true
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Protein
G3UW65
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
G3UZ49
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
Q8CIP2
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: true
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Protein
A2AKM6
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Protein
A0A087WST9
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
G3UX39
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
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Protein
A2ALK0
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: true
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Protein
A2AKM7
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: false
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Protein
A2AIU6
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: true
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Protein
Q8VHP0
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
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Protein
G3UZ20
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
G3UZ71
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
Q3UZ60
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
I6YXB9
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Protein
A2AKM5
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: false
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Protein
A2AKM8
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
V9GXS5
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
G3V008
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
Q8VDB7
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
A0A0R4J267
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q3V1K1
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
P47239
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
P32115
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
P24610
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
P63015
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q8VDB3
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q9CZK7
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Protein
Q3UGH9
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
Q8VHL9
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: true
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Protein
G3UX36
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Protein
G3UZE8
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
A2RRY5
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
B7ZNC8
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: false
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Protein
Q3TZM4
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Protein
Q8BRF1
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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