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Search results 2201 to 2300 out of 2720 for Runx2

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Type Details Score
Pathway
R-MMU-8941326 | RUNX2 regulates bone development
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Pathway
R-MMU-8940973 | RUNX2 regulates osteoblast differentiation
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Publication
25264196 | J:220214
First Author: Huang Q
Year: 2014
Journal: Biochem Biophys Res Commun
Title: MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone.
Volume: 453
Issue: 1
Pages: 160-5
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Publication
34778386 | J:314724
 
First Author: Dharmarajan S
Year: 2021
Journal: Front Cardiovasc Med
Title: Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models.
Volume: 8
Pages: 687210
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Publication
30971697 | J:285495
First Author: Kubota S
Year: 2019
Journal: Nat Commun
Title: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.
Volume: 10
Issue: 1
Pages: 1653
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Publication
27149837 | J:235475
     
First Author: Chopin M
Year: 2016
Journal: Cell Rep
Title: RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity.
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Interaction Experiment
Hesse E (2010)
Description: Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity.
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Interaction Experiment
Zheng HL (2021)
Description: Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination.
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Publication
26208651 | J:256890
First Author: Raaz U
Year: 2015
Journal: Circ Res
Title: Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus.
Volume: 117
Issue: 6
Pages: 513-24
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Publication
29016735 | J:268370
First Author: Yu C
Year: 2018
Journal: Cardiovasc Res
Title: LncRNA TUG1 sponges miR-204-5p to promote osteoblast differentiation through upregulating Runx2 in aortic valve calcification.
Volume: 114
Issue: 1
Pages: 168-179
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Publication
38396954 | J:360455
 
First Author: Jiang Q
Year: 2024
Journal: Int J Mol Sci
Title: Runx2 Regulates Galnt3 and Fgf23 Expressions and Galnt3 Decelerates Osteoid Mineralization by Stabilizing Fgf23.
Volume: 25
Issue: 4
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Publication
25257467 | J:311557
First Author: Kim HJ
Year: 2014
Journal: Cell Res
Title: Plant homeodomain finger protein 2 promotes bone formation by demethylating and activating Runx2 for osteoblast differentiation.
Volume: 24
Issue: 10
Pages: 1231-49
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Publication
26141838 | J:228151
 
First Author: Ko JY
Year: 2015
Journal: Bone
Title: MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation.
Volume: 81
Pages: 80-8
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Publication
32903671 | J:308908
 
First Author: Dai G
Year: 2020
Journal: Front Cell Dev Biol
Title: LncRNA H19 Regulates BMP2-Induced Hypertrophic Differentiation of Mesenchymal Stem Cells by Promoting Runx2 Phosphorylation.
Volume: 8
Pages: 580
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Publication
39747056 | J:361090
First Author: Yamashita Y
Year: 2025
Journal: Nat Commun
Title: Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation.
Volume: 16
Issue: 1
Pages: 9
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Publication
27554624 | J:251797
 
First Author: Liu P
Year: 2016
Journal: Sci Rep
Title: Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation.
Volume: 6
Pages: 32112
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GXD Expression
GXD Expression
 
Probe: MGI:6888381
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1834022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6888387
Age: embryonic day 14.5
Note: Co-expression with Runx2 at end of sphenoid bone.
Specimen Label: 2C/E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6888381
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1834022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6888387
Age: embryonic day 14.5
Note: Co-expression with Runx2 at end of sphenoid bone.
Specimen Label: 2D/F
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6473765
Assay Type: RNA in situ
Annotation Date: 2020-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6473773
Age: embryonic day 14.0
Note: Co-expression with Runx2 in dental papilla and dental follicle.
Specimen Label: 1C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6473765
Assay Type: RNA in situ
Annotation Date: 2020-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3527522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6473773
Age: embryonic day 14.0
Note: Co-expression with Runx2 in dental papilla and dental follicle.
Specimen Label: 1C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6473765
Assay Type: RNA in situ
Annotation Date: 2020-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3290722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6473773
Age: embryonic day 14.0
Note: Co-expression with Runx2 in mesenchymal cells in alveolar bone,
Specimen Label: 1C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6473765
Assay Type: RNA in situ
Annotation Date: 2020-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3290726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6473773
Age: embryonic day 18.0
Note: Expression in alveolar bone osteoblasts overlapped with Runx2 expression.
Specimen Label: 1K
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6473765
Assay Type: RNA in situ
Annotation Date: 2020-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3290726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6473773
Age: embryonic day 18.0
Note: Expression in alveolar bone osteoblasts overlapped with Runx2 expression.
Specimen Label: S1G
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6473765
Assay Type: RNA in situ
Annotation Date: 2020-11-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3290726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6473773
Age: embryonic day 18.0
Note: Expression in alveolar bone osteoblasts overlapped with Runx2 expression.
Specimen Label: S1K
Detected: true
Specimen Num: 6
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Publication
16000302 | J:100924
First Author: Roca H
Year: 2005
Journal: J Biol Chem
Title: Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene.
Volume: 280
Issue: 35
Pages: 30845-55
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Publication
20530675 | J:161600
First Author: Kurek KC
Year: 2010
Journal: Cancer Res
Title: Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.
Volume: 70
Issue: 13
Pages: 5577-86
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Publication
17456773 | J:121080
First Author: Merciris D
Year: 2007
Journal: Am J Pathol
Title: Overexpression of the transcriptional factor Runx2 in osteoblasts abolishes the anabolic effect of parathyroid hormone in vivo.
Volume: 170
Issue: 5
Pages: 1676-85
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Publication
17060321 | J:117674
First Author: Hassan MQ
Year: 2006
Journal: J Biol Chem
Title: BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.
Volume: 281
Issue: 52
Pages: 40515-26
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Pathway
R-MMU-8939902 | Regulation of RUNX2 expression and activity
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Interaction Experiment
Zhang M (2009)
Description: PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation.
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Interaction Experiment
Zhu W (2017)
Description: The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation.
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Interaction Experiment
Marcellini S (2010)
Description: Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis.
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Publication
24106268 | -
First Author: Yang D
Year: 2013
Journal: J Biol Chem
Title: Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.
Volume: 288
Issue: 47
Pages: 33530-41
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Publication
27687725 | J:237640
First Author: Stechschulte LA
Year: 2016
Journal: J Biol Chem
Title: Protein Phosphatase PP5 Controls Bone Mass and the Negative Effects of Rosiglitazone on Bone through Reciprocal Regulation of PPARγ (Peroxisome Proliferator-activated Receptor γ) and RUNX2 (Runt-related Transcription Factor 2).
Volume: 291
Issue: 47
Pages: 24475-24486
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GXD Expression
GXD Expression
 
Probe: MGI:6888381
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6888387
Age: embryonic day 14.5
Note: Co-expression with Runx2 in numerous cells in mesenchymal cell condensation of medial pterygoid process of sphenoid bone.
Specimen Label: 2C/E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5787662
Assay Type: Immunohistochemistry
Annotation Date: 2016-08-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3523821
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5787769
Age: embryonic day 13.5
Image: 5A/C
Note: Expressed in the mesenchymal mass of the developing zygomatic bone. Increased overlap between FOXP1 and RUNX2 compared with E12.5.
Specimen Label: 5A/C
Detected: true
Specimen Num: 3
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Publication
22575641 | -
First Author: Byun MR
Year: 2012
Journal: FEBS Lett
Title: Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation.
Volume: 586
Issue: 8
Pages: 1086-92
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Allele
Ccd | MGI:1861187
 
Name: cleidocranial dysplasia
Allele Type: Radiation induced
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Allele
Runx2<tm1Mjo> | MGI:2176465
Name: runt related transcription factor 2; targeted mutation 1, Michael J Owen
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Runx2<tm1Jals> | MGI:3829607
Name: runt related transcription factor 2; targeted mutation 1, Janet L Stein
Allele Type: Targeted
Attribute String: Hypomorph
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Publication
30035248 | J:286030
First Author: Khalid AB
Year: 2018
Journal: JBMR Plus
Title: GATA4 Directly Regulates Runx2 Expression and Osteoblast Differentiation.
Volume: 2
Issue: 2
Pages: 81-91
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Interaction Experiment
Li X (2023)
Description: USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice.
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Allele
Gt(ROSA)26Sor<tm3(Runx2)Flng> | MGI:5311032
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Fanxin Long
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Protein Coding Gene
MGI:1858214 | Ppm1d
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9QZ67
Organism: Mus musculus/domesticus
Length: 598  
Fragment?: false
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Heritable Phenotypic Marker
MGI:88291 | Ccd
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Allele
Runx2<tm1Kish> | MGI:2176466
Name: runt related transcription factor 2; targeted mutation 1, Tadamitsu Kishimoto
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Ccd/Ccd<+>
Background: involves: 101 * C3H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Runx2/Runx2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccd/Ccd<+>
Background: B10Rl.101-Ccd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Runx2/Runx2
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Runx2/Runx2<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:13994 | cleidocranial dysplasia
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Publication
20236534 | -
 
First Author: Marcellini S
Year: 2010
Journal: BMC Evol Biol
Title: Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis.
Volume: 10
Pages: 78
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Allele
Runx2<em1Smoc> | MGI:7292142
Name: runt related transcription factor 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Protein Coding Gene
MGI:1929092 | Rbm14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8C2Q3
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: false
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Genotype
Genotype
Symbol: Runx2/Runx2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0111513 | metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome
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Strain
MGI:6751641 | B6.129X1(Cg)-Gt(ROSA)26Sor<tm3(Runx2)Flng>/J
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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GO Term
GO:0016513 | core-binding factor complex
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Protein
Q08775-5
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: false
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HT Experiment
E-GEOD-4911 | Transcription profiling of mouse pooled embryonic humeri E14.5 from wild type and RUNX2-/- mutants detects novel skeletogenesis target genes
Series Id: GSE4911
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
37415159 | -
First Author: Li X
Year: 2023
Journal: Biol Direct
Title: USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice.
Volume: 18
Issue: 1
Pages: 37
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Allele
Tg(Col2a1-Runx2*)3Tok | MGI:2447359
Name: transgene insertion 3, Toshihisa Komori
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:7623477 | C57BL/6JSmoc-Runx2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Coding Gene
MGI:98371 | Sox9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109452 | Smad1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q04887
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
P70340
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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HT Experiment
E-GEOD-59081 | Axin2/Runx2 mouse calvaria gene expression
Series Id: GSE59081
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-59079 | Axin2/Runx2 mouse calvaria microRNA expression
Series Id: GSE59079
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:99851 | Cbfb
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Tg(Col2a1-Runx2)1Tok | MGI:2447357
Name: transgene insertion 1, Toshihisa Komori
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Col2a1-Runx2)2Tok | MGI:2447358
Name: transgene insertion 2, Toshihisa Komori
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Col2a1-Runx2*)4Tok | MGI:2447360
Name: transgene insertion 4, Toshihisa Komori
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Twist1<Ska10> | MGI:3038818
 
Name: twist basic helix-loop-helix transcription factor 1; skeletal/axial 10
Allele Type: Chemically induced (ENU)
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Allele
Tg(Runx2-icre)1Jtuc | MGI:4455015
Name: transgene insertion 1, Jan Tuckermann
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Runx2<tm1Hkiy> | MGI:5750983
Name: runt related transcription factor 2; targeted mutation 1, Hiroshi Kiyono
Allele Type: Targeted
Attribute String: Modified isoform(s)
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Genotype
Genotype
Symbol: Runx2/Runx2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Runx2/Runx2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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HT Experiment
E-SMDB-3396 | Transcription profiling of juvenile and adult calvarial bone
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Strain
MGI:5609939 | C57BL/6J-Twist1<Ska10>
Attribute String: coisogenic, chemically induced mutation, mutant strain
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Strain
MGI:3042009 | C3;B6-Twist1<Ska10>/Mmucd
Attribute String: mutant stock, chemically induced mutation
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Genotype
Genotype
Symbol: Twist1/Twist1<+>
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Twist1/Twist1<+>
Background: C57BL/6J-Twist1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Twist1/Twist1
Background: C57BL/6J-Twist1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Ihh/Ihh Tg(Col2a1-cre)3Amc/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Runx2/Runx2 Tg(Col2a1-cre)3Amc/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Runx2/Runx2 Tg(Col2a1-cre)3Amc/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ihh/Ihh Tg(Col2a1-cre)3Amc/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Twist1/Twist1
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Protein
Q8K0Z1
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Publication
24798337 | -
First Author: Walport LJ
Year: 2014
Journal: J Biol Chem
Title: Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
Volume: 289
Issue: 26
Pages: 18302-13
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Publication
24797517 | -
First Author: Williams K
Year: 2014
Journal: PLoS One
Title: The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner.
Volume: 9
Issue: 5
Pages: e96545
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Publication
19451217 | J:148469
First Author: Agger K
Year: 2009
Journal: Genes Dev
Title: The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.
Volume: 23
Issue: 10
Pages: 1171-6
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Publication
24646476 | -
First Author: Kamikawa YF
Year: 2014
Journal: Epigenetics
Title: The localization of histone H3K27me3 demethylase Jmjd3 is dynamically regulated.
Volume: 9
Issue: 6
Pages: 834-41
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Protein Domain
IPR029518 | KDM6B
Type: Family
Description: This entry represents lysine-specific demethylase 6B (also known as JMJD3 or KDM6B). UTX (also known as KDM6A), JMJD3 (also known as KDM6B) and UTY (also known as KDM6C) are the members of the JmjC (Jumonji C) subfamily of the histone lysine demethylases family (KDM). They are histone demethylases that catalyse demethylation of H3K27, a mark important for transcriptional repression []. Unlike KDM6A, KDM6B is highly regulated at the transcriptional level and is upregulated in response to oncogenic stress [, ]. It is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner []. It also plays important roles in osteoblast differentiation and regulates the expressions of bone sialoprotein and osteocalcin via transcription factors Runx2 and osterix []. Its subcellular localisation is dynamically regulated and has pivotal roles for H3K27me3 status [].
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