Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Repeat |
Description: |
This region of sequence similarity is found up to six times in a variety of proteins including general transcription factor II-I (GTF2I). It has been suggested that this may be a DNA binding domain [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
936
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kopp ND |
Year: |
2020 |
Journal: |
Hum Mol Genet |
Title: |
Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA binding and long-term behavioral consequences. |
Volume: |
29 |
Issue: |
9 |
Pages: |
1498-1519 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enkhmandakh B |
Year: |
2016 |
Journal: |
Genesis |
Title: |
Generation of a mouse model for a conditional inactivation of Gtf2i allele. |
Volume: |
54 |
Issue: |
7 |
Pages: |
407-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
He Y |
Year: |
2022 |
Journal: |
J Thorac Oncol |
Title: |
A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation. |
Volume: |
17 |
Issue: |
12 |
Pages: |
1375-1386 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giorgetti OB |
Year: |
2022 |
Journal: |
Commun Biol |
Title: |
Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice. |
Volume: |
5 |
Issue: |
1 |
Pages: |
1037 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mervis CB |
Year: |
2012 |
Journal: |
Am J Hum Genet |
Title: |
Duplication of GTF2I results in separation anxiety in mice and humans. |
Volume: |
90 |
Issue: |
6 |
Pages: |
1064-70 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1104
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Borralleras C |
Year: |
2015 |
Journal: |
Mol Ther |
Title: |
Intracisternal Gtf2i Gene Therapy Ameliorates Deficits in Cognition and Synaptic Plasticity of a Mouse Model of Williams-Beuren Syndrome. |
Volume: |
23 |
Issue: |
11 |
Pages: |
1691-1699 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kopp N |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models. |
Volume: |
28 |
Issue: |
20 |
Pages: |
3443-3465 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
345
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
74
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
437
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
249
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
169
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
262
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
66
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
167
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
167
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
150
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
325
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Mahoney JV |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
Identification of a novel slow-muscle-fiber enhancer binding protein, MusTRD1. |
Volume: |
18 |
Issue: |
11 |
Pages: |
6641-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osborne LR |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Identification of a putative transcription factor gene (WBSCR11) that is commonly deleted in Williams-Beuren syndrome. |
Volume: |
57 |
Issue: |
2 |
Pages: |
279-84 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
998
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
962
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1045
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
942
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1077
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
913
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
871
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1045
|
Fragment?: |
false |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin LA |
Year: |
2018 |
Journal: |
Brain Behav |
Title: |
Consistent hypersocial behavior in mice carrying a deletion of Gtf2i but no evidence of hyposocial behavior with Gtf2i duplication: Implications for Williams-Beuren syndrome and autism spectrum disorder. |
Volume: |
8 |
Issue: |
1 |
Pages: |
e00895 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
45
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohazama A |
Year: |
2007 |
Journal: |
Dev Dyn |
Title: |
TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome. |
Volume: |
236 |
Issue: |
10 |
Pages: |
2884-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakurai T |
Year: |
2011 |
Journal: |
Autism Res |
Title: |
Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions. |
Volume: |
4 |
Issue: |
1 |
Pages: |
28-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Palmer SJ |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members. |
Volume: |
125 |
Issue: |
Pt 21 |
Pages: |
5040-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barak B |
Year: |
2019 |
Journal: |
Nat Neurosci |
Title: |
Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug. |
Volume: |
22 |
Issue: |
5 |
Pages: |
700-708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh A |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
Transcription factor TFII-I fine tunes innate properties of B lymphocytes. |
Volume: |
14 |
|
Pages: |
1067459 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deurloo MHS |
Year: |
2019 |
Journal: |
Mol Neurobiol |
Title: |
Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models. |
Volume: |
56 |
Issue: |
5 |
Pages: |
3313-3325 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang YK |
Year: |
1998 |
Journal: |
Genomics |
Title: |
A mouse single-copy gene, Gtf2i, the homolog of human GTF2I, that is duplicated in the Williams-Beuren syndrome deletion region. |
Volume: |
48 |
Issue: |
2 |
Pages: |
163-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bayarsaihan D |
Year: |
2002 |
Journal: |
Genomics |
Title: |
Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region. |
Volume: |
79 |
Issue: |
1 |
Pages: |
137-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enkhmandakh B |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development. |
Volume: |
106 |
Issue: |
1 |
Pages: |
181-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fijalkowska I |
Year: |
2010 |
Journal: |
BMC Res Notes |
Title: |
Expression of the transcription factor, TFII-I, during post-implantation mouse embryonic development. |
Volume: |
3 |
|
Pages: |
203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li HH |
Year: |
2009 |
Journal: |
EMBO Mol Med |
Title: |
Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. |
Volume: |
1 |
Issue: |
1 |
Pages: |
50-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lucena J |
Year: |
2010 |
Journal: |
BMC Med Genet |
Title: |
Essential role of the N-terminal region of TFII-I in viability and behavior. |
Volume: |
11 |
|
Pages: |
61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Segura-Puimedon M |
Year: |
2013 |
Journal: |
Gene |
Title: |
TFII-I regulates target genes in the PI-3K and TGF-β signaling pathways through a novel DNA binding motif. |
Volume: |
527 |
Issue: |
2 |
Pages: |
529-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enkhmandakh B |
Year: |
2004 |
Journal: |
Gene Expr Patterns |
Title: |
The early embryonic expression of TFII-I during mouse preimplantation development. |
Volume: |
4 |
Issue: |
1 |
Pages: |
25-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grad M |
Year: |
2022 |
Journal: |
Cells |
Title: |
Altered White Matter and microRNA Expression in a Murine Model Related to Williams Syndrome Suggests That miR-34b/c Affects Brain Development via Ptpru and Dcx Modulation. |
Volume: |
11 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Gurumurthy A |
Year: |
2020 |
Journal: |
Front Physiol |
Title: |
TFII-I/Gtf2i and Erythro-Megakaryopoiesis. |
Volume: |
11 |
|
Pages: |
590180 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hakre S |
Year: |
2006 |
Journal: |
Mol Cell |
Title: |
Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. |
Volume: |
24 |
Issue: |
2 |
Pages: |
301-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ashworth T |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Cutting Edge: TFII-I controls B cell proliferation via regulating NF-kappaB. |
Volume: |
178 |
Issue: |
5 |
Pages: |
2631-5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6305690 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6305691 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6305692 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6305693 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6305700 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6305701 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6305702 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6305703 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6305704 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6305705 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6305706 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6305707 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6305712 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6305714 |
Age: |
postnatal adult |
|
|
Specimen Label: |
7 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1339733 |
Assay Type: |
Northern blot |
Annotation Date: |
2024-08-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7707763 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Spleen |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6305690 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6305691 |
Age: |
postnatal adult |
|
|
Specimen Label: |
9 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|