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Search results 101 to 157 out of 157 for Upf1

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Type Details Score
Publication
29236296 | -
 
First Author: M Plank TD
Year: 2018
Journal: Bioessays
Title: RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.
Volume: 40
Issue: 1
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Allele
Upf1<tm1Hcd> | MGI:2386175
Name: UPF1 RNA helicase and ATPase; targeted mutation 1, Harry C Dietz
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Upf1<Gt(PST13395)Mfgc> | MGI:3862589
 
Name: UPF1 RNA helicase and ATPase; gene trap PST13395, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Upf1<Gt(XR0413)Wtsi> | MGI:3877165
 
Name: UPF1 RNA helicase and ATPase; gene trap XR0413, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Upf1<Gt(F012A01)Wrst> | MGI:4123487
 
Name: UPF1 RNA helicase and ATPase; gene trap F012A01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Upf1<Gt(PST4227)Mfgc> | MGI:4341960
 
Name: UPF1 RNA helicase and ATPase; gene trap PST4227, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Upf1<Gt(EUCE305d11)Hmgu> | MGI:4374639
 
Name: UPF1 RNA helicase and ATPase; gene trap EUCE305d11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Upf1<Gt(EUCE0179h12)Hmgu> | MGI:4377226
 
Name: UPF1 RNA helicase and ATPase; gene trap EUCE0179h12, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Upf1<Gt(EUCE0075b02)Hmgu> | MGI:4396826
 
Name: UPF1 RNA helicase and ATPase; gene trap EUCE0075b02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Upf1<em2Gpt> | MGI:7308263
Name: UPF1 RNA helicase and ATPase; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7588900 | C57BL/6J-Upf1<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Upf1<em1Smoc> | MGI:7766854
Name: UPF1 RNA helicase and ATPase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Upf1<em2Smoc> | MGI:7766855
Name: UPF1 RNA helicase and ATPase; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
25013172 | -
First Author: Chakrabarti S
Year: 2014
Journal: Nucleic Acids Res
Title: Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6.
Volume: 42
Issue: 14
Pages: 9447-60
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Strain
MGI:7767267 | C57BL/6JSmoc-Upf1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7767730 | C57BL/6JSmoc-Upf1<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Upf1/Upf1
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
24726324 | -
First Author: Gregersen LH
Year: 2014
Journal: Mol Cell
Title: MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Volume: 54
Issue: 4
Pages: 573-85
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Publication
16452507 | -
First Author: Kashima I
Year: 2006
Journal: Genes Dev
Title: Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
Volume: 20
Issue: 3
Pages: 355-67
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Protein Domain
IPR040812 | UPF1_1B_dom
Type: Domain
Description: UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are nonenzymatic components of the complex that stimulate the activity of UPF1 []. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1).This is 1B domain of UPF1 which has a regulatory role. It suffers conformational changes from an inhibitory state to a transition-state complex that modulate RNA binding [, ].
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Allele
Tg(ACTB-UPF1*R844C)581Hcd | MGI:4820740
Name: transgene insertion 581, Harry C Dietz
Allele Type: Transgenic
Attribute String: Dominant negative, Humanized sequence, Inserted expressed sequence
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Publication
32737261 | J:295983
 
First Author: Echols J
Year: 2020
Journal: Dis Model Mech
Title: A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases.
Volume: 13
Issue: 8
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Allele
Upf2<tm1.1Btp> | MGI:3790199
Name: UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1.1, Bo Torben Porse
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:4820751 | B6.Cg-Tg(ACTB-UPF1*R844C)581Hcd/J
Attribute String: transgenic, mutant strain, congenic
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Publication
- | J:162990
     
First Author: Dietz HC
Year: 2010
Journal: MGI Direct Data Submission
Title: JR strain 10939
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Allele
Tg(tetO-UPF1*R844C)3438Kmke | MGI:7787080
Name: transgene insertion 3438, Kim M Keeling
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
16931876 | -
First Author: Kadlec J
Year: 2006
Journal: RNA
Title: Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1.
Volume: 12
Issue: 10
Pages: 1817-24
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Protein Domain
IPR018999 | UPF1_CH/ZBD
Type: Domain
Description: UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are nonenzymatic components of the complex that stimulate the activity of UPF1 []. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1).This is the N-terminal CH/ZBD which contains 3 zinc binding motifs that interacts with UPF2 and it also has a cis-inhibitory effect on the ATPase activity. After binding to UPF2, the CH/ZBD suffers a large conformational change that causes the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity [, ].
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Genotype
Genotype
Symbol: Upf2/Upf2
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Upf2/Upf2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR039762 | Nmd2/UPF2
Type: Family
Description: This entry includes Nmd2 from yeasts and UPF2 from animals. They are involved in the nonsense-mediated mRNA decay (NMD) pathway [, ]. In the human UPF complex (composed of UPF1/2/3), UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1 [].
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Publication
36255229 | J:331055
 
First Author: Chousal JN
Year: 2022
Journal: Development
Title: Progression of the pluripotent epiblast depends upon the NMD factor UPF2.
Volume: 149
Issue: 21
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Protein
Q9EPU0
Organism: Mus musculus/domesticus
Length: 1124  
Fragment?: false
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Publication
9032286 | -
First Author: He F
Year: 1997
Journal: Mol Cell Biol
Title: Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.
Volume: 17
Issue: 3
Pages: 1580-94
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Publication
23359859 | J:198011
 
First Author: Eom T
Year: 2013
Journal: Elife
Title: NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.
Volume: 2
Pages: e00178
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Strain
MGI:7788387 | STOCK Gt(ROSA)26Sor<tm1.1(rtTA,EGFP)Nagy> Tg(tetO-UPF1*R844C)3438Kmke/J
Attribute String: mutant stock, targeted mutation, transgenic
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Publication
18362360 | J:189981
First Author: Agranat L
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.
Volume: 105
Issue: 13
Pages: 5028-33
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Publication
25744026 | J:258608
First Author: Jia J
Year: 2015
Journal: Cell Death Differ
Title: Caspases shutdown nonsense-mediated mRNA decay during apoptosis.
Volume: 22
Issue: 11
Pages: 1754-63
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Genotype
Genotype
Symbol: Upf2/Upf2 Tg(Stra8-icre)1Reb/?
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Publication
16289965 | -
First Author: Yamashita A
Year: 2005
Journal: Biochim Biophys Acta
Title: The role of SMG-1 in nonsense-mediated mRNA decay.
Volume: 1754
Issue: 1-2
Pages: 305-15
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Publication
17229728 | -
First Author: Morita T
Year: 2007
Journal: J Biol Chem
Title: Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay.
Volume: 282
Issue: 11
Pages: 7799-808
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Protein Domain
IPR039414 | SMG1_PIKKc
Type: Domain
Description: SMG-1 plays a critical role in the mRNA surveillance mechanism known as non-sense mediated mRNA decay (NMD). NMD protects the cells from the accumulation of aberrant mRNAs with premature termination codons (PTCs) generated by genome mutations and by errors during transcription and splicing. SMG-1 phosphorylates Upf1, another central component of NMD, at the C terminus upon recognition of PTCs. The phosphorylation/dephosphorylation cycle of Upf1 is essential for promoting NMD []. In addition to its catalytic domain, SMG-1 contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain at the C terminus. SMG-1 is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470kDa) []. This entry represents the SMG-1 catalytic domain.
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Protein Domain
IPR044340 | Helicase_Sen1_1B_dom
Type: Domain
Description: The yeast helicase Sen1 is an ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs [, ]and it also has an ATPase-dependent ability of promoting transcription termination in vitro []. Sen1 has a key role at replication forks during DNA replication to promote fork progression and chromosome stability []. Sen1 belongs to the superfamily 1B UPF1-like family of helicases with a common domain organisation: a N-terminal domain and a C-terminal domain which contains the SF1B helicase with two RecA domains (RecA1 and RecA2) and the classical helicase motifs involved in nucleic acid binding and ATP hydrolysis. It also contains two SF1B-specific subdomains (1B and 1C) that modulate RNA binding. This entry represents the 1B regulatory domain found in the helicase Sen1 from S. cerevisiae, which has a more elaborate topology of the 1B barrel domain from that of UPF1 [].
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Publication
26656492 | J:253173
First Author: Sanchez G
Year: 2016
Journal: Nucleic Acids Res
Title: A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy.
Volume: 44
Issue: 6
Pages: 2661-76
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Publication
24185201 | J:210040
First Author: Cho H
Year: 2013
Journal: Biochim Biophys Acta
Title: SMG1 regulates adipogenesis via targeting of staufen1-mediated mRNA decay.
Volume: 1829
Issue: 12
Pages: 1276-87
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Publication
11163187 | -
First Author: Lykke-Andersen J
Year: 2000
Journal: Cell
Title: Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
Volume: 103
Issue: 7
Pages: 1121-31
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Publication
18483223 | J:134765
First Author: Weischenfeldt J
Year: 2008
Journal: Genes Dev
Title: NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.
Volume: 22
Issue: 10
Pages: 1381-96
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Protein
A2AT37
Organism: Mus musculus/domesticus
Length: 1269  
Fragment?: false
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Protein
F6Q3G7
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: true
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Publication
32075754 | -
First Author: Appanah R
Year: 2020
Journal: Cell Rep
Title: Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability.
Volume: 30
Issue: 7
Pages: 2094-2105.e9
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Publication
28444146 | J:247924
First Author: MacDonald CC
Year: 2017
Journal: Biol Reprod
Title: Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.
Volume: 96
Issue: 5
Pages: 939-947
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Publication
15121901 | -
First Author: Ursic D
Year: 2004
Journal: Nucleic Acids Res
Title: Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription-coupled DNA repair and RNA processing.
Volume: 32
Issue: 8
Pages: 2441-52
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Publication
28408439 | -
First Author: Leonaitė B
Year: 2017
Journal: EMBO J
Title: Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family.
Volume: 36
Issue: 11
Pages: 1590-1604
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Publication
8943355 | -
First Author: Steinmetz EJ
Year: 1996
Journal: Mol Cell Biol
Title: Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1.
Volume: 16
Issue: 12
Pages: 6993-7003
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Protein
Q8BKX6
Organism: Mus musculus/domesticus
Length: 3658  
Fragment?: false
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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