Testis-expressed sequence 15 protein (TEXT15), also known as cancer/testis antigen 42, is a testis-specific protein. It is also expressed in several cancers [, ]. TEXT15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis [].
This entry represents a domain found in TEX15, a protein required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination []. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population [].
