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Search results 101 to 200 out of 505 for Pick1

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Type Details Score
GXD Expression
Probe: MGI:6831103
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3522328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6831210
Age: postnatal adult
Image: 3D
Note: Highest expression. Expressed in the perinuclear region.
Specimen Label: 3D
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6831103
Assay Type: Immunohistochemistry
Annotation Date: 2021-12-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3522328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6831206
Age: postnatal adult
Image: 3C
Note: Highest expression. Expressed in the perinuclear region.
Specimen Label: 3C
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4417073
Assay Type: RNA in situ
Annotation Date: 2023-09-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7530796
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
Publication  
First Author: Mignogna ML
Year: 2015
Journal: Nat Commun
Title: The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.
Volume: 6
Pages: 6504
Publication
First Author: Schonewille M
Year: 2011
Journal: Neuron
Title: Reevaluating the role of LTD in cerebellar motor learning.
Volume: 70
Issue: 1
Pages: 43-50
Publication
First Author: Selak S
Year: 2009
Journal: Neuron
Title: A role for SNAP25 in internalization of kainate receptors and synaptic plasticity.
Volume: 63
Issue: 3
Pages: 357-71
Publication
First Author: Torres R
Year: 1998
Journal: Neuron
Title: PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.
Volume: 21
Issue: 6
Pages: 1453-63
Publication
First Author: Reymond N
Year: 2005
Journal: FEBS Lett
Title: PICK-1: a scaffold protein that interacts with Nectins and JAMs at cell junctions.
Volume: 579
Issue: 10
Pages: 2243-9
Publication
First Author: Chanrion B
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.
Volume: 104
Issue: 19
Pages: 8119-24
Publication
First Author: Bygrave AM
Year: 2023
Journal: Cell Rep
Title: Btbd11 supports cell-type-specific synaptic function.
Volume: 42
Issue: 6
Pages: 112591
Publication  
First Author: Tomioka NH
Year: 2014
Journal: Nat Commun
Title: Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.
Volume: 5
Pages: 4501
Publication
First Author: Mäkinen T
Year: 2005
Journal: Genes Dev
Title: PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.
Volume: 19
Issue: 3
Pages: 397-410
Publication
First Author: Karataeva AR
Year: 2014
Journal: PLoS One
Title: C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9.
Volume: 9
Issue: 2
Pages: e87360
Publication  
First Author: Chenaux G
Year: 2016
Journal: eNeuro
Title: Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo.
Volume: 3
Issue: 5
Publication
First Author: Araki S
Year: 2015
Journal: Circulation
Title: Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway.
Volume: 132
Issue: 12
Pages: 1081-93
Publication  
First Author: Liu K
Year: 2016
Journal: Sci Rep
Title: Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.
Volume: 6
Pages: 21019
Publication
First Author: Takamiya K
Year: 2004
Journal: Nat Genet
Title: A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.
Volume: 36
Issue: 2
Pages: 172-7
Publication
First Author: Longatti A
Year: 2021
Journal: Mol Neurobiol
Title: Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.
Volume: 58
Issue: 12
Pages: 6092-6110
Publication
First Author: Bouwman J
Year: 2006
Journal: J Neurochem
Title: Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.
Volume: 99
Issue: 1
Pages: 84-96
Publication      
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
Publication
First Author: Desai J
Year: 2006
Journal: Hum Mol Genet
Title: Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Volume: 15
Issue: 8
Pages: 1329-41
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication
First Author: Rocca DL
Year: 2008
Journal: Nat Cell Biol
Title: Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis.
Volume: 10
Issue: 3
Pages: 259-71
Publication
First Author: Madsen KL
Year: 2008
Journal: Traffic
Title: Membrane localization is critical for activation of the PICK1 BAR domain.
Volume: 9
Issue: 8
Pages: 1327-43
Interaction Experiment
Description: Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels.
Interaction Experiment
Description: PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect.
Publication
First Author: Lu W
Year: 2005
Journal: Neuron
Title: PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.
Volume: 47
Issue: 3
Pages: 407-21
Publication
First Author: Shao X
Year: 2010
Journal: Neurochem Int
Title: Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization.
Volume: 56
Issue: 8
Pages: 962-70
Publication
First Author: Laezza F
Year: 2008
Journal: Neuropharmacology
Title: The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors.
Volume: 55
Issue: 7
Pages: 1131-9
Interaction Experiment
Description: The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons.
Publication
First Author: Jaulin-Bastard F
Year: 2001
Journal: J Biol Chem
Title: The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins.
Volume: 276
Issue: 18
Pages: 15256-63
Publication
First Author: Thomas GM
Year: 2013
Journal: J Neurosci
Title: DHHC8-dependent PICK1 palmitoylation is required for induction of cerebellar long-term synaptic depression.
Volume: 33
Issue: 39
Pages: 15401-7
Publication
First Author: Thorsen TS
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
Volume: 107
Issue: 1
Pages: 413-8
Publication
First Author: Hanley JG
Year: 2008
Journal: Pharmacol Ther
Title: PICK1: a multi-talented modulator of AMPA receptor trafficking.
Volume: 118
Issue: 1
Pages: 152-60
Publication
First Author: Dev KK
Year: 2006
Journal: Trends Pharmacol Sci
Title: The schizophrenic faces of PICK1.
Volume: 27
Issue: 11
Pages: 574-9
Publication  
First Author: Xu J
Journal: Neurosignals
Title: Structure and function of PICK1.
Volume: 15
Issue: 4
Pages: 190-201
Protein Domain
Type: Domain
Description: Protein Interacting with C Kinase 1 (PICK1) is highly expressed in brain and testes. It plays a key role in the trafficking of AMPA receptors, which are critical for regulating synaptic strength and may be important in cellular processes involved in learning and memory [, ]. PICK1 is also critical in the early stages of spermiogenesis. Mice deficient in PICK1 are infertile and show characteristics of the human disease globozoospermia such as round-headed sperm, reduced sperm count, and severely impaired sperm motility []. PICK1 may also be involved in the neuropathogenesis of schizophrenia [].PICK1 contains an N-terminal PDZ domain and a C-terminal BAR domain [], also designated as AH (arfaptin homology) domain []. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of PICK1 is necessary for its membrane localization and activation [, ].
Publication
First Author: Chen L
Year: 2020
Journal: FEBS Lett
Title: Islet-cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfβ signaling in mice.
Volume: 594
Issue: 17
Pages: 2881-2893
Publication  
First Author: Fujihara Y
Year: 2017
Journal: Int J Mol Sci
Title: Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models.
Volume: 18
Issue: 10
Publication
First Author: Xu NJ
Year: 2011
Journal: Nat Neurosci
Title: A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.
Volume: 14
Issue: 11
Pages: 1421-9
Publication
First Author: Tarricone C
Year: 2001
Journal: Nature
Title: The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
Volume: 411
Issue: 6834
Pages: 215-9
Protein Domain
Type: Domain
Description: The arfaptin homology (AH) domain is a protein domain found in a range of proteins, including arfaptins, protein kinase C-binding protein PICK1 []and mammalian 69kDa islet cell autoantigen (ICA69) []. The AH domain of arfaptin has been shown to dimerise and to bind Arf and Rho family GTPases [, ], including ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules.The AH domain consists of three α-helices arranged as an extended antiparallel α-helical bundle. Two arfaptin AH domains associate to form a highly elongated, crescent-shaped dimer [, ].
Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
Publication
First Author: Jourdi H
Year: 2003
Journal: Dev Biol
Title: Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons.
Volume: 263
Issue: 2
Pages: 216-30
Publication
First Author: Liu C
Year: 2017
Journal: Development
Title: Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice.
Volume: 144
Issue: 3
Pages: 441-451
Publication
First Author: Tossidou I
Year: 2010
Journal: PLoS One
Title: Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis.
Volume: 5
Issue: 4
Pages: e10185
Protein
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: false
Publication
First Author: Nakamura K
Year: 2012
Journal: J Biol Chem
Title: Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.
Volume: 287
Issue: 30
Pages: 25478-89
Protein Domain
Type: Family
Description: This family consists of Arfaptin-1, Arfaptin-2, and protein kinase C-binding protein 1 (PICK1). They all contain a Bin/amphiphysin/Rvs (BAR) domain []. BAR-domain-containing proteins are key players in membrane dynamics as their crescent shape allows them to sense or generate curvature on lipid bilayers [].Arfaptin-1 and 2 have been shown to interact with Arf GTPases and Arf-like 1 (Arl1). They are recruited to trans-Golgi membranes through interaction with Arl1 [].In neurons, PICK1 forms homodimers and serves as one of the scaffolding proteins that interacts with AMPA receptors and regulates their trafficking in synaptic plasticity []. In pancreatic beta cells, it forms heteromeric BAR-domain complexes with another cytosolic lipid-binding protein, ICA69. Together they are key regulators of the formation and maturation of insulin granules [].
Protein
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 431  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
Publication
First Author: Spitzenberger F
Year: 2003
Journal: J Biol Chem
Title: Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.
Volume: 278
Issue: 28
Pages: 26166-73
Publication
First Author: Cherfils J
Year: 2001
Journal: FEBS Lett
Title: Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors.
Volume: 507
Issue: 3
Pages: 280-4
Protein
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false