Type |
Details |
Score |
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Sittaramane V |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. |
Volume: |
382 |
Issue: |
2 |
Pages: |
400-12 |
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Publication |
First Author: |
Lei YP |
Year: |
2010 |
Journal: |
N Engl J Med |
Title: |
VANGL2 mutations in human cranial neural-tube defects. |
Volume: |
362 |
Issue: |
23 |
Pages: |
2232-5 |
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Interaction Experiment |
Description: |
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. |
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Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Yingzi Yang |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Epitope tag, Inserted expressed sequence |
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Interaction Experiment |
Description: |
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. |
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Allele |
Name: |
intergenic site 1; targeted mutation 4, Jeremy Nathans |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, No functional change, Reporter |
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Strain |
Attribute String: |
mutant stock, targeted mutation |
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Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Yingzi Yang |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Epitope tag, Inserted expressed sequence |
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•
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Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Yingzi Yang |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Epitope tag, Inserted expressed sequence |
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Genotype |
Symbol: |
Igs1/Igs1 |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
526
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
521
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
253
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
575
|
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
102
|
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
393
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
130
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
137
|
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
561
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
476
|
Fragment?: |
false |
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Publication |
First Author: |
Hatakeyama J |
Year: |
2014 |
Journal: |
Endocr Relat Cancer |
Title: |
Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. |
Volume: |
21 |
Issue: |
5 |
Pages: |
R345-56 |
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Protein Domain |
Type: |
Family |
Description: |
VANGL proteins play important roles in the establishment of planar cell polarity (PCP) []. Vangl2 is required for retinal axon guidance [], kidney-branching morphogenesis and glomerular maturation []. It also plays a role in the orientation of stereociliary bundles in the cochlea and is required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process []. It is required for cell surface localization of FZD3 and FZD6 in the inner ear []. |
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HT Experiment |
Series Id: |
GSE24276 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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Publication |
First Author: |
Ban Y |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex. |
Volume: |
7 |
Issue: |
41 |
Pages: |
eabh2974 |
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Publication |
First Author: |
Cheong SS |
Year: |
2023 |
Journal: |
Dis Model Mech |
Title: |
A method for TAT-Cre recombinase-mediated floxed allele modification in ex vivo tissue slices. |
Volume: |
16 |
Issue: |
11 |
|
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•
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Publication |
First Author: |
Yang T |
Year: |
2014 |
Journal: |
Cell Tissue Res |
Title: |
Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons. |
Volume: |
357 |
Issue: |
3 |
Pages: |
549-61 |
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•
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Publication |
First Author: |
Treat AC |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
The PDZ Protein Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) Regulates Planar Cell Polarity and Motile Cilia Organization. |
Volume: |
11 |
Issue: |
4 |
Pages: |
e0153144 |
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•
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Publication |
First Author: |
Seo JH |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. |
Volume: |
20 |
Issue: |
22 |
Pages: |
4324-33 |
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•
•
•
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•
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Publication |
First Author: |
Hayashi K |
Year: |
2011 |
Journal: |
Biol Reprod |
Title: |
WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development. |
Volume: |
84 |
Issue: |
2 |
Pages: |
308-19 |
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•
•
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•
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Publication |
First Author: |
Richards T |
Year: |
2019 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
Atmin modulates Pkhd1 expression and may mediate Autosomal Recessive Polycystic Kidney Disease (ARPKD) through altered non-canonical Wnt/Planar Cell Polarity (PCP) signalling. |
Volume: |
1865 |
Issue: |
2 |
Pages: |
378-390 |
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•
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•
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Publication |
First Author: |
Goodyear RJ |
Year: |
2017 |
Journal: |
Development |
Title: |
A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane. |
Volume: |
144 |
Issue: |
21 |
Pages: |
3978-3989 |
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•
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Publication |
First Author: |
Moreno-Fortuny A |
Year: |
2017 |
Journal: |
Biol Open |
Title: |
MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation. |
Volume: |
6 |
Issue: |
11 |
Pages: |
1592-1601 |
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•
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•
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Publication |
First Author: |
Fernández-Santos B |
Year: |
2023 |
Journal: |
Dis Model Mech |
Title: |
The loop-tail mouse model displays open and closed caudal neural tube defects. |
Volume: |
16 |
Issue: |
8 |
|
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•
•
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•
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Publication |
First Author: |
The Jackson Laboratory |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
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