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Search results 301 to 400 out of 747 for Vav1

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Type Details Score
Publication
22683124 | J:187430
First Author: Dong Z
Year: 2012
Journal: Immunity
Title: The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Volume: 36
Issue: 6
Pages: 974-85
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Publication
8164679 | J:17787
First Author: Bae SC
Year: 1994
Journal: Mol Cell Biol
Title: PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.
Volume: 14
Issue: 5
Pages: 3242-52
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Publication
8288240 | J:15564
First Author: Okazaki T
Year: 1993
Journal: Genomics
Title: Molecular diversity of the SCG10/stathmin gene family in the mouse.
Volume: 18
Issue: 2
Pages: 360-73
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Publication
19141316 | J:148967
First Author: Glassmann A
Year: 2009
Journal: Neuroscience
Title: Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.
Volume: 159
Issue: 1
Pages: 69-82
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Publication
15728722 | J:100216
First Author: Aoki K
Year: 2005
Journal: Mol Biol Cell
Title: Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.
Volume: 16
Issue: 5
Pages: 2207-17
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Publication
10679268 | J:64951
First Author: Masuhara M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
Volume: 268
Issue: 3
Pages: 697-703
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Publication
18606643 | J:137420
First Author: Hara H
Year: 2008
Journal: J Immunol
Title: Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.
Volume: 181
Issue: 2
Pages: 918-30
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Publication
31591574 | J:282407
First Author: Voisinne G
Year: 2019
Journal: Nat Immunol
Title: Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.
Volume: 20
Issue: 11
Pages: 1530-1541
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Publication
21257963 | J:169412
First Author: Boyle KB
Year: 2011
Journal: J Immunol
Title: Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.
Volume: 186
Issue: 5
Pages: 2978-89
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Publication
9811459 | J:50937
First Author: Okada H
Year: 1998
Journal: Oncogene
Title: AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.
Volume: 17
Issue: 18
Pages: 2287-93
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Publication
8211130 | J:14384
First Author: Copeland NG
Year: 1993
Journal: Science
Title: A genetic linkage map of the mouse: current applications and future prospects.
Volume: 262
Issue: 5130
Pages: 57-66
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Publication
8530024 | J:25776
First Author: Steingrímsson E
Year: 1995
Journal: Genomics
Title: Murine chromosomal location of five bHLH-Zip transcription factor genes.
Volume: 28
Issue: 2
Pages: 179-83
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Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
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Publication
35326399 | J:322608
 
First Author: Shalom B
Year: 2022
Journal: Cells
Title: Vav1 Promotes B-Cell Lymphoma Development.
Volume: 11
Issue: 6
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Publication
- | J:104190
     
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Protein Domain
IPR035729 | VAV1_SH3_2
Type: Domain
Description: VAV1 (also known as proto-oncogene vav) is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells [, , ]. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization [, ]. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. This entry represents the second SH3 domain of VAV1. This domain interacts with a wide variety of proteins including cytoskeletal regulators (zyxin), RNA-binding proteins (Sam68), transcriptional regulators, viral proteins, and dynamin 2 [].
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Protein Domain
IPR035730 | VAV1_SH3_1
Type: Domain
Description: VAV1 (also known as proto-oncogene vav) is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells [, , ]. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization [, ]. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. This entry represents the first SH3 domain of VAV1.
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Pathway
R-MMU-389359 | CD28 dependent Vav1 pathway
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Publication
25531316 | J:224247
First Author: Lindsey JC
Year: 2015
Journal: Oncogene
Title: Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance.
Volume: 34
Issue: 36
Pages: 4746-57
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Publication
17237383 | J:143660
First Author: Dennehy KM
Year: 2007
Journal: J Immunol
Title: Mitogenic CD28 signals require the exchange factor Vav1 to enhance TCR signaling at the SLP-76-Vav-Itk signalosome.
Volume: 178
Issue: 3
Pages: 1363-71
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Interaction Experiment
Raberger J (2008)
Description: Impaired T-cell development in the absence of Vav1 and Itk.
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Publication
30410484 | J:302816
 
First Author: Bernard I
Year: 2018
Journal: Front Immunol
Title: A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire.
Volume: 9
Pages: 2399
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Publication
32079227 | J:304892
 
First Author: Hong J
Year: 2020
Journal: Int J Mol Sci
Title: The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain.
Volume: 21
Issue: 4
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Publication
32317318 | J:292169
 
First Author: Teymournejad O
Year: 2020
Journal: mBio
Title: Ehrlichia chaffeensis Uses an Invasin To Suppress Reactive Oxygen Species Generation by Macrophages via CD147-Dependent Inhibition of Vav1 To Block Rac1 Activation.
Volume: 11
Issue: 2
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Allele
Commd10<Tg(Vav1-icre)A2Kio> | MGI:2449949
Name: COMM domain containing 10; transgene insertion A2, Dimitris Kioussis
Allele Type: Transgenic
Attribute String: Null/knockout, Recombinase
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Publication
12405184 | -
 
First Author: Turner M
Year: 2002
Journal: Adv Exp Med Biol
Title: The role of Vav proteins in B cell responses.
Volume: 512
Pages: 29-34
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Publication
14592821 | -
First Author: Katzav S
Year: 2004
Journal: Blood
Title: Vav1: an oncogene that regulates specific transcriptional activation of T cells.
Volume: 103
Issue: 7
Pages: 2443-51
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Publication
17590270 | -
First Author: Katzav S
Year: 2007
Journal: Cancer Lett
Title: Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies.
Volume: 255
Issue: 2
Pages: 241-54
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Publication
12670394 | -
 
First Author: Tybulewicz VL
Year: 2003
Journal: Immunol Rev
Title: Vav1: a key signal transducer downstream of the TCR.
Volume: 192
Pages: 42-52
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Publication
12165654 | -
First Author: Michel F
Year: 2002
Journal: Sci STKE
Title: CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?
Volume: 2002
Issue: 144
Pages: pe35
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Publication
18511940 | -
First Author: Rapley J
Year: 2008
Journal: EMBO Rep
Title: Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.
Volume: 9
Issue: 7
Pages: 655-61
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Publication
15850391 | -
First Author: Heo J
Year: 2005
Journal: Biochemistry
Title: Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.
Volume: 44
Issue: 17
Pages: 6573-85
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Publication
15886116 | -
First Author: Tybulewicz VL
Year: 2005
Journal: Curr Opin Immunol
Title: Vav-family proteins in T-cell signalling.
Volume: 17
Issue: 3
Pages: 267-74
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Allele
Tg(Vav1-STAT5B)731Biat | MGI:6164041
Name: transgene insertion 731, Biomodels Austria
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Vav1<em1Smoc> | MGI:7293112
Name: vav 1 oncogene; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
17050525 | -
First Author: Miletic AV
Year: 2006
Journal: J Biol Chem
Title: Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation.
Volume: 281
Issue: 50
Pages: 38257-65
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Strain
MGI:6164044 | C57BL/6NCrl-Tg(Vav1-STAT5B)731Biat/Biat
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6429773 | C57BL/6J-Vav1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Tg(Vav1-STAT5B)731Biat/?
Background: C57BL/6NCrl-Tg(Vav1-STAT5B)731Biat/Biat
Zygosity: ot
Has Mutant Allele: true
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Allele
Tg(Vav1-cre)1Cgp | MGI:2450339
Name: transgene insertion 1, Cristin G Print
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Vav1-cre/ERT2)#Boui | MGI:6113431
Name: transgene insertion, Philippe Bouillet
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Publication
29200404 | J:257519
First Author: Pham HTT
Year: 2018
Journal: J Clin Invest
Title: STAT5BN642H is a driver mutation for T cell neoplasia.
Volume: 128
Issue: 1
Pages: 387-401
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Allele
Tg(Vav1-STAT5B*N642H)726Biat | MGI:6164037
Name: transgene insertion 726, Biomodels Austria
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Allele
Tg(Vav1-ERG)#Jpim | MGI:5141633
Name: transgene insertion, John E Pimanda
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Vav1-HBEGF,-GFP)1Cfors | MGI:7464989
Name: transgene insertion 1, Camilla Forsberg
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Protein Coding Gene
MGI:88327 | Cd28
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101773 | Cd86
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101775 | Cd80
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P42082
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
P31041
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q00609
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Publication
29113963 | J:257690
First Author: Yang H
Year: 2018
Journal: Blood
Title: Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.
Volume: 131
Issue: 3
Pages: 328-341
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Strain
MGI:6335544 | C57BL/6N-Tg(STAT5BN/H)726Biat
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6164042 | C57BL/6NCrl-Tg(Vav1-STAT5B*N642H)726Biat
Attribute String: mutant strain, transgenic, coisogenic
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Allele
Tg(Vav1-cre)8Cgp | MGI:4888391
Name: transgene insertion 8, Cristin G Print
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
23974202 | J:203438
First Author: Goldberg L
Year: 2013
Journal: Blood
Title: Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
Volume: 122
Issue: 15
Pages: 2694-703
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Strain
MGI:7607342 | C57BL/6J-Tg(Vav1-HBEGF,-GFP)1Cfors/Mmucd
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(Vav1-cre)1Awr | MGI:3043860
Name: transgene insertion 1, Andrew W Roberts
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Vav1-cre)#Cgp | MGI:5527187
Name: transgene insertion, Cristin G Print
Allele Type: Transgenic
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Tg(Vav1-ERG)#Jpim/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Vav1-STAT5B*N642H)726Biat/?
Background: C57BL/6NCrl-Tg(Vav1-STAT5B*N642H)726Biat
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:1339656 | Pak3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61036
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Publication
31175292 | J:283551
First Author: de Araujo ED
Year: 2019
Journal: Nat Commun
Title: Structural and functional consequences of the STAT5BN642H driver mutation.
Volume: 10
Issue: 1
Pages: 2517
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Publication
31395598 | J:278804
First Author: Hsu YC
Year: 2019
Journal: Blood Adv
Title: Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials.
Volume: 3
Issue: 15
Pages: 2355-2367
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Allele
Tg(Vav1-Mpl)EAmol | MGI:7387062
Name: transgene insertion E, Alison Moliterno
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
33586242 | J:306148
First Author: Chen Y
Year: 2021
Journal: Cell Prolif
Title: Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.
Volume: 54
Issue: 3
Pages: e12972
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Allele
Tg(Vav1-Mpl)AAmol | MGI:7387059
Name: transgene insertion A, Alison Moliterno
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Vav1<m1Btlr> | MGI:6199670
Name: vav 1 oncogene; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6199671 | C57BL/6J-Vav1<m1Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Allele
Vav1<M4Btlr> | MGI:6285514
Name: vav 1 oncogene; mutation 4, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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