| Type |
Details |
Score |
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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•
•
•
•
•
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| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
•
•
•
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| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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•
•
•
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| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
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•
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•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
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•
•
•
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| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
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•
•
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| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
•
•
|
| Publication |
| First Author: |
Liu Y |
| Year: |
2023 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression. |
| Volume: |
324 |
| Issue: |
5 |
| Pages: |
C1007-C1016 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
U7 snRNA-associated Sm-like protein LSm11 |
| Type: |
chain |
| End: |
361 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wagner EJ |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. |
| Volume: |
26 |
| Issue: |
17 |
| Pages: |
6702-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aik WS |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. |
| Volume: |
12 |
| Issue: |
10 |
| Pages: |
e0186034 |
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•
•
•
•
•
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| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the middle domain of Lsm11.The eukaryotic Sm and Sm-like (Lsm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel β-sheet [, , ]. Lsm11 is an SmD2-like subunit which binds U7 snRNA along with Lsm10 and five other Sm subunits to form a 7-membered ring structure. Lsm11 and the U7 snRNP of which it is a part are thought to play an important role in histone mRNA 3' processing [, ]. |
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•
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•
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1962
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
251
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
286
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
632
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
190
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barcaroli D |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
FLASH is an essential component of Cajal bodies. |
| Volume: |
103 |
| Issue: |
40 |
| Pages: |
14802-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Minamida Y |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
FLASH/casp8ap2 is indispensable for early embryogenesis but dispensable for proliferation and differentiation of ES cells. |
| Volume: |
9 |
| Issue: |
9 |
| Pages: |
e108032 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
CASP8-associated protein 2 (CASP8AP2), also known as FLASH, is involved in various cellular functions, such as cell cycle progression, transcriptional regulation, the regulation of apoptosis, and the regulation of histone gene expression []. It is an essential component of Cajal bodies and is involved in the apoptosis receptor signaling pathway [].FLASH contains the N terminus required for histone pre-mRNA processing, the C-terminal segment which forms a SANT/Myb-like domain, and a small central region which binds Ars2 essential for cell cycle progression []. Its N-terminal domain has been found to form a 2:1 heterotrimer with Lsm11 for histone pre-mRNA 3'-end processing []. |
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•
•
•
•
•
|
| Publication |
| First Author: |
Tisdale S |
| Year: |
2022 |
| Journal: |
Cell Rep |
| Title: |
SMN controls neuromuscular junction integrity through U7 snRNP. |
| Volume: |
40 |
| Issue: |
12 |
| Pages: |
111393 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 4, Daniel Schuemperli |
| Allele Type: |
Transgenic |
| Attribute String: |
Knockdown, Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nlend RN |
| Year: |
2012 |
| Journal: |
Methods Mol Biol |
| Title: |
Antisense genes to induce exon inclusion. |
| Volume: |
867 |
|
| Pages: |
325-47 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meyer K |
| Year: |
2009 |
| Journal: |
Hum Mol Genet |
| Title: |
Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation. |
| Volume: |
18 |
| Issue: |
3 |
| Pages: |
546-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Neve A |
| Year: |
2016 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Central and peripheral defects in motor units of the diaphragm of spinal muscular atrophy mice. |
| Volume: |
70 |
|
| Pages: |
30-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Voigt T |
| Year: |
2010 |
| Journal: |
Neuromuscul Disord |
| Title: |
Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing. |
| Volume: |
20 |
| Issue: |
11 |
| Pages: |
744-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huo Q |
| Year: |
2014 |
| Journal: |
RNA Biol |
| Title: |
Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: evidence for involvement of splicing regulatory proteins. |
| Volume: |
11 |
| Issue: |
11 |
| Pages: |
1430-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo A |
| Year: |
2014 |
| Journal: |
Mol Cell Proteomics |
| Title: |
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
372-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
| Volume: |
10 |
| Issue: |
10 |
| Pages: |
1617-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
1999 |
| Journal: |
Methods Enzymol |
| Title: |
High-efficiency full-length cDNA cloning. |
| Volume: |
303 |
|
| Pages: |
19-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shibata K |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
1757-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Katayama S |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
Antisense transcription in the mammalian transcriptome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1564-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
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•
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