Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
rabbit, European |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-01-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1897623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:5448197 |
Age: |
embryonic day 15.5 |
Image: |
3B Fmo1 |
Note: |
Expression was detected in the proximal convoluted tubules. |
Specimen Label: |
3B Fmo1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Veeravalli S |
Year: |
2014 |
Journal: |
Biochem Pharmacol |
Title: |
The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. |
Volume: |
90 |
Issue: |
1 |
Pages: |
88-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hernandez D |
Year: |
2009 |
Journal: |
Pharmacogenet Genomics |
Title: |
Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. |
Volume: |
19 |
Issue: |
4 |
Pages: |
289-99 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172991 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190291 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Fmo1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172991 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190291 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Fmo1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172991 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190291 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Fmo1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172991 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190291 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Fmo1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172991 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190291 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Fmo1 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172991 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190291 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Fmo1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172991 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190291 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Fmo1 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Veeravalli S |
Year: |
2020 |
Journal: |
Drug Metab Dispos |
Title: |
Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. |
Volume: |
48 |
Issue: |
5 |
Pages: |
378-385 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li B |
Year: |
2021 |
Journal: |
Neurosci Lett |
Title: |
Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice. |
Volume: |
764 |
|
Pages: |
136222 |
|
•
•
•
•
•
|
Publication |
First Author: |
Itoh K |
Year: |
1997 |
Journal: |
J Toxicol Sci |
Title: |
Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). |
Volume: |
22 |
Issue: |
1 |
Pages: |
45-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Falls JG |
Year: |
1995 |
Journal: |
J Biochem Toxicol |
Title: |
Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice. |
Volume: |
10 |
Issue: |
3 |
Pages: |
171-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cherrington NJ |
Year: |
1998 |
Journal: |
J Biochem Mol Toxicol |
Title: |
Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5). |
Volume: |
12 |
Issue: |
4 |
Pages: |
205-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Falls JG |
Year: |
1997 |
Journal: |
Arch Biochem Biophys |
Title: |
Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids. |
Volume: |
342 |
Issue: |
2 |
Pages: |
212-23 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2769723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2853323 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2845723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1795023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1869223 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2762123 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797223 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1832123 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2851823 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2760523 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2852723 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5000848 |
Assay Type: |
RNA in situ |
Annotation Date: |
2014-02-07 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:2850023 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5541407 |
Age: |
embryonic day 15.5 |
Image: |
GUDMAP:9620 |
|
Specimen Label: |
GUDMAP:9620 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang X |
Year: |
2017 |
Journal: |
Elife |
Title: |
Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Valerius MT |
Year: |
2008 |
Journal: |
Gene Expr Patterns |
Title: |
Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. |
Volume: |
8 |
Issue: |
5 |
Pages: |
297-306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brown AC |
Year: |
2005 |
Journal: |
BMC Genet |
Title: |
Searching QTL by gene expression: analysis of diabesity. |
Volume: |
6 |
|
Pages: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Allele |
Name: |
deletion, Chr 1, Elizabeth A Shephard 1 |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
congenic, mutant strain, deletion |
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Genotype |
Symbol: |
Del(1Fmo4-Fmo2)1Eshe/+ |
Background: |
B6.129P2-Del(1Fmo4-Fmo2)1Eshe |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Del(1Fmo4-Fmo2)1Eshe/Del(1Fmo4-Fmo2)1Eshe |
Background: |
B6.129P2-Del(1Fmo4-Fmo2)1Eshe |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Veeravalli S |
Year: |
2018 |
Journal: |
Drug Metab Dispos |
Title: |
Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis. |
Volume: |
46 |
Issue: |
1 |
Pages: |
20-25 |
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Publication |
First Author: |
Lawton MP |
Year: |
1994 |
Journal: |
Arch Biochem Biophys |
Title: |
A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. |
Volume: |
308 |
Issue: |
1 |
Pages: |
254-7 |
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Publication |
First Author: |
Bennett BJ |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. |
Volume: |
17 |
Issue: |
1 |
Pages: |
49-60 |
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Protein Domain |
Type: |
Family |
Description: |
Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes []. Using an NADPH cofactor and FAD prosthetic group, these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorous and selenium atoms in a range of structurally diverse compounds. FMOs have been implicated in the metabolism of a number of pharmaceuticals, pesticides and toxicants. In man, lack of hepatic FMO-catalysed trimethylamine metabolism results in trimethylaminuria (fish odour syndrome). Five mammalian forms of FMO are now known and have been designated FMO1-FMO5 [, , , , ].Human FMO1 mRNA is more abundant in foetal than in adult liver, indicating that the enzyme is subject to developmental regulation in man []. The deduced amino sequence contains putative FAD- (GxGxxG) and NADP+-binding (GxGxxA) sites, a 'FATGY' motif that has also been observed in a range of siderphore biosynthetic enzymes [], and a C-terminal hydrophobic segment that is believed to anchor the monooxygenase to the microsomal membrane []. The human sequence shares 88 and 86% identity, respectively, with pig and rabbit 'hepatic' forms of FMO, but is only 58% similar to the abbit 'pulmonary' FMO []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
537
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
221
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
537
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
229
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Fragment?: |
true |
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Publication |
First Author: |
Ozols J |
Year: |
1990 |
Journal: |
J Biol Chem |
Title: |
Covalent structure of liver microsomal flavin-containing monooxygenase form 1. |
Volume: |
265 |
Issue: |
18 |
Pages: |
10289-99 |
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