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Search results 501 to 572 out of 572 for Ncf1

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Type Details Score
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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DO Term
DOID:0070192 | autosomal recessive chronic granulomatous disease 1
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Publication
11827466 | J:73801
First Author: Bayarsaihan D
Year: 2002
Journal: Genomics
Title: Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region.
Volume: 79
Issue: 1
Pages: 137-43
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Allele
Ncf1<em1Smoc> | MGI:7291245
Name: neutrophil cytosolic factor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Ncf1<tm1Tbph> | MGI:6191621
Name: neutrophil cytosolic factor 1; targeted mutation 1, University of Turku, Department of Physiology
Allele Type: Targeted
Attribute String: Null/knockout
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Protein Domain
IPR032136 | NCF1_PBR/AIR
Type: Domain
Description: This entry represents the polybasic or autoinhibitory region (PBR/AIR, an arginine/lysine rich region) found after the second SH3 domain in neutrophil cytosol factor 1 (NCF1/p47phox) []. NCF1 is one of the cytosolic regulatory components of NADPH oxidase and consists of a PX domain at the N-terminal, two tandem SH3 domains, a PBR/AIR and a proline-rich region at the C-terminal. In the resting state, the SH3 domains of NCF1 are masked by an intramolecular interaction with the PBR/AIR, which maintains the enzyme in an inactive form [].
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Publication
16326715 | -
First Author: Ogura K
Year: 2006
Journal: J Biol Chem
Title: NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide.
Volume: 281
Issue: 6
Pages: 3660-8
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Allele
Ncf1<m1J> | MGI:2661962
 
Name: neutrophil cytosolic factor 1; mutation 1, Jackson
Allele Type: Spontaneous
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Strain
MGI:6770971 | C57BL/6JSmoc-Nc<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
12169629 | -
First Author: Kami K
Year: 2002
Journal: EMBO J
Title: Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.
Volume: 21
Issue: 16
Pages: 4268-76
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Protein Domain
IPR015039 | NCF1_C
Type: Domain
Description: NCF1 (also known as NADPH oxidase subunit p47Phox) is one of the cytosolic regulatory components of NADPH oxidase and consists of a PX domain at the N-terminal, two tandem SH3 domains, a polybasic or autoinhibitory region (PBR/AIR, an arginine/lysine rich region) and a proline-rich region at the C-terminal. In the resting state, the SH3 domains of NCF1 are masked by an intramolecular interaction with the PBR/AIR, which maintains the enzyme in an inactive form []. This entry represents the C-terminal domain which contains conserved PxxP motifs that allow binding to SH3 domains, with subsequent activation of the NADPH oxidase, and generation of superoxide, which plays a crucial role in host defence against microbial infection [].
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Strain
MGI:2665642 | B6(Cg)-Ncf1<m1J>/J
Attribute String: mutant strain, coisogenic, spontaneous mutation
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Strain
MGI:5750590 | B10.Cg-Ncf1<m1J> H2<q>/Kctt
Attribute String: spontaneous mutation, mutant strain, major histocompatibility congenic, congenic
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Strain
MGI:4887387 | NOD.Cg-Ncf1<m1J>/MxJ
Attribute String: congenic, mutant strain, spontaneous mutation
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Strain
MGI:6195753 | B10.Cg-Ncf1<m1J> H2<q>/Rhd
Attribute String: major histocompatibility congenic, congenic, mutant strain, spontaneous mutation
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Strain
MGI:3709657 | B6.Cg-Ncf1<m1J> H2<q>
Attribute String: congenic, mutant strain, spontaneous mutation, major histocompatibility congenic
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Genotype
Genotype
Symbol: Ncf1/Ncf1
Background: B6.Cg-Dock7 +/+ Lepr/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: H2/? Ncf1/Ncf1
Background: B6.Cg-Ncf1 H2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ncf1/Ncf1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ncf1/Ncf1
Background: B6(Cg)-Ncf1/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: H2/? Ncf1/Ncf1
Background: B10.Cg-Ncf1 H2/Rhd
Zygosity: cx
Has Mutant Allele: true
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Publication
12732142 | -
First Author: Groemping Y
Year: 2003
Journal: Cell
Title: Molecular basis of phosphorylation-induced activation of the NADPH oxidase.
Volume: 113
Issue: 3
Pages: 343-55
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Publication
20645308 | J:164059
First Author: Flaherty JP
Year: 2010
Journal: Genesis
Title: Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1).
Volume: 48
Issue: 9
Pages: 568-75
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Publication
36707536 | J:344572
First Author: Shahin WS
Year: 2023
Journal: Nat Commun
Title: Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate.
Volume: 14
Issue: 1
Pages: 444
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Protein Domain
IPR034885 | PB1_P67
Type: Domain
Description: NADPH oxidase is a multisubunit complex that assembles during phagocytosis to generate reactive oxygen species. NCF2 (p67-phox), NCF1 (p47-phox) are required for activation of the phagocyte NADPH oxidase. The activators p67-phox and p47-phox form a ternary complex together with adaptor protein p40-phox, which participates in activation of the phagocyte oxidase by regulating membrane recruitment of p67-phox and p47-phox [, ].A PB1 domain is present in p67-phox. p40-phox associates with p67-phox via binding of the p40-phox PC motif to the p67-phox PB1 domain [].PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions []. The p67-phox proteins contain a type II PB1 domain.
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Publication
26503985 | J:258491
First Author: Kyrychenko S
Year: 2015
Journal: Cardiovasc Res
Title: Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.
Volume: 108
Issue: 3
Pages: 324-34
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Publication
22049077 | J:178839
First Author: Kozel BA
Year: 2011
Journal: J Biol Chem
Title: Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation.
Volume: 286
Issue: 52
Pages: 44926-36
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Publication
21268010 | J:175428
First Author: Pizzolla A
Year: 2011
Journal: Eur J Immunol
Title: CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species.
Volume: 41
Issue: 2
Pages: 403-12
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Publication
35587260 | J:342728
   
First Author: James J
Year: 2022
Journal: Elife
Title: Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation.
Volume: 11
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Publication
17909630 | J:286664
First Author: Gelderman KA
Year: 2007
Journal: J Clin Invest
Title: Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species.
Volume: 117
Issue: 10
Pages: 3020-8
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Publication
38886341 | J:349879
First Author: Li L
Year: 2024
Journal: Nat Commun
Title: NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance.
Volume: 15
Issue: 1
Pages: 5170
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Publication
25116588 | J:216185
First Author: Trocme C
Year: 2015
Journal: J Pathol
Title: Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways.
Volume: 235
Issue: 1
Pages: 65-78
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Publication
33222683 | J:351116
First Author: Greve HJ
Year: 2020
Journal: J Neuroinflammation
Title: Diesel exhaust impairs TREM2 to dysregulate neuroinflammation.
Volume: 17
Issue: 1
Pages: 351
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Publication
39201793 | J:357635
 
First Author: Martin LJ
Year: 2024
Journal: Int J Mol Sci
Title: Nuclear Localization of Human SOD1 in Motor Neurons in Mouse Model and Patient Amyotrophic Lateral Sclerosis: Possible Links to Cholinergic Phenotype, NADPH Oxidase, Oxidative Stress, and DNA Damage.
Volume: 25
Issue: 16
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Publication
32019585 | J:298472
First Author: Khaw YM
Year: 2020
Journal: J Neuroinflammation
Title: Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis.
Volume: 17
Issue: 1
Pages: 49
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Protein
Q09014
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
F8WH69
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Protein
Q3UBI5
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Protein
Q7TMH0
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
Q3UA02
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: true
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Protein
Q3U9Y3
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Publication
12207919 | -
First Author: Yoshida L
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Expression of a p67(phox) homolog in Caco-2 cells giving O(2)(-)-reconstituting ability to cytochrome b(558) together with recombinant p47(phox).
Volume: 296
Issue: 5
Pages: 1322-8
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Publication
27487400 | -
First Author: Kuribayashi F
Year: 2016
Journal: EMBO J
Title: The adaptor protein p40phox as a positive regulator of the superoxide-producing phagocyte oxidase.
Volume: 35
Issue: 3
Pages: 369-70
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Protein
S4R293
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Publication
17726178 | -
First Author: Sumimoto H
Year: 2007
Journal: Sci STKE
Title: Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants.
Volume: 2007
Issue: 401
Pages: re6
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Protein
O70145
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Protein
Q1PCS1
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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