Type |
Details |
Score |
Genotype |
Symbol: |
Mecp2/Mecp2 |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/Mecp2<+> |
Background: |
B6.129(FVB)-Mecp2 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/Mecp2<+> |
Background: |
B6.129(FVB)-Mecp2 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/Mecp2 |
Background: |
B6.129P2(C)-Mecp2/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
172
![FASTA](model/images/fasta.gif) |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
189
![FASTA](model/images/fasta.gif) |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
482
![FASTA](model/images/fasta.gif) |
Fragment?: |
false |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE52261 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/? Tg(MECP2)1Hzo/? |
Background: |
involves: 129P2/OlaHsd * FVB |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/? Tg(MECP2*R270X/GFP)AHzo/? |
Background: |
involves: 129P2/OlaHsd * FVB |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/? Sum1/Sum1<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/? Sum2/Sum2<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/? Sum4/Sum4<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/? Sum5/Sum5<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
554
![FASTA](model/images/fasta.gif) |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
554
![FASTA](model/images/fasta.gif) |
Fragment?: |
false |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mapt/Mapt<+> Mecp2/Mecp2<+> |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mbd2/Mbd2 Mecp2/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/? Tg(MECP2*G273X/GFP)AHzo/? |
Background: |
involves: 129P2/OlaHsd * FVB |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/? Sqle/Sqle<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/Mecp2 |
Background: |
B6.129(FVB)-Mecp2 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mecp2/Mecp2 |
Background: |
B6.129(FVB)-Mecp2 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Witteveen JS |
Year: |
2016 |
Journal: |
Nat Genet |
Title: |
Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. |
Volume: |
48 |
Issue: |
8 |
Pages: |
877-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mastrototaro G |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
TBL1XR1 Ensures Balanced Neural Development Through NCOR Complex-Mediated Regulation of the MAPK Pathway. |
Volume: |
9 |
|
Pages: |
641410 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carrette LLG |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders. |
Volume: |
115 |
Issue: |
4 |
Pages: |
E668-E675 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lewis JD |
Year: |
1992 |
Journal: |
Cell |
Title: |
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. |
Volume: |
69 |
Issue: |
6 |
Pages: |
905-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kameshita I |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1. |
Volume: |
377 |
Issue: |
4 |
Pages: |
1162-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park J |
Year: |
2018 |
Journal: |
Nucleic Acids Res |
Title: |
Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization. |
Volume: |
46 |
Issue: |
22 |
Pages: |
11759-11775 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glaich O |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
DNA methylation directs microRNA biogenesis in mammalian cells. |
Volume: |
10 |
Issue: |
1 |
Pages: |
5657 |
|
•
•
•
•
•
|
Publication |
First Author: |
Apulei J |
Year: |
2019 |
Journal: |
Cereb Cortex |
Title: |
Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g. |
Volume: |
29 |
Issue: |
6 |
Pages: |
2384-2395 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gupta S |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Histone methylation regulates memory formation. |
Volume: |
30 |
Issue: |
10 |
Pages: |
3589-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stagni F |
Year: |
2015 |
Journal: |
Neurobiol Dis |
Title: |
Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice. |
Volume: |
74 |
|
Pages: |
204-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aten S |
Year: |
2018 |
Journal: |
Learn Mem |
Title: |
miR-132 couples the circadian clock to daily rhythms of neuronal plasticity and cognition. |
Volume: |
25 |
Issue: |
5 |
Pages: |
214-229 |
|
•
•
•
•
•
|
Publication |
First Author: |
Subbanna S |
Year: |
2018 |
Journal: |
Front Mol Neurosci |
Title: |
CB1R-Mediated Activation of Caspase-3 Causes Epigenetic and Neurobehavioral Abnormalities in Postnatal Ethanol-Exposed Mice. |
Volume: |
11 |
|
Pages: |
45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hernandez-Rapp J |
Year: |
2015 |
Journal: |
Behav Brain Res |
Title: |
Memory formation and retention are affected in adult miR-132/212 knockout mice. |
Volume: |
287 |
|
Pages: |
15-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng C |
Year: |
2018 |
Journal: |
Hum Mol Genet |
Title: |
The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities. |
Volume: |
27 |
Issue: |
24 |
Pages: |
4303-4314 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi J |
Year: |
2019 |
Journal: |
Aging Cell |
Title: |
Hyperoxygenation revitalizes Alzheimer's disease pathology through the upregulation of neurotrophic factors. |
Volume: |
18 |
Issue: |
2 |
Pages: |
e12888 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loers G |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
The Cell Adhesion Molecule L1 Interacts with Methyl CpG Binding Protein 2 via Its Intracellular Domain. |
Volume: |
23 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bormann D |
Year: |
2021 |
Journal: |
Cells |
Title: |
miRNA-132/212 Gene-Deletion Aggravates the Effect of Oxygen-Glucose Deprivation on Synaptic Functions in the Female Mouse Hippocampus. |
Volume: |
10 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Boggio EM |
Year: |
2016 |
Journal: |
Neuroscience |
Title: |
Visual impairment in FOXG1-mutated individuals and mice. |
Volume: |
324 |
|
Pages: |
496-508 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patriarchi T |
Year: |
2016 |
Journal: |
Eur J Hum Genet |
Title: |
Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice. |
Volume: |
24 |
Issue: |
6 |
Pages: |
871-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin C |
Year: |
2005 |
Journal: |
Hum Mol Genet |
Title: |
CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders. |
Volume: |
14 |
Issue: |
24 |
Pages: |
3775-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katryniok C |
Year: |
2010 |
Journal: |
Biochim Biophys Acta |
Title: |
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity. |
Volume: |
1801 |
Issue: |
1 |
Pages: |
49-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nandakumar V |
Year: |
2011 |
Journal: |
Carcinogenesis |
Title: |
Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice. |
Volume: |
32 |
Issue: |
4 |
Pages: |
597-604 |
|
•
•
•
•
•
|
Publication |
First Author: |
Subbanna S |
Year: |
2014 |
Journal: |
Neuroscience |
Title: |
Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. |
Volume: |
258 |
|
Pages: |
422-32 |
|
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•
•
•
•
|
Publication |
First Author: |
Lv YC |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis. |
Volume: |
11 |
Issue: |
6 |
Pages: |
e0157265 |
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Publication |
First Author: |
Jin HJ |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression. |
Volume: |
7 |
Issue: |
1 |
Pages: |
14926 |
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Publication |
First Author: |
Cholewa-Waclaw J |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic. |
Volume: |
116 |
Issue: |
30 |
Pages: |
14995-15000 |
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Publication |
First Author: |
Epstein RJ |
Year: |
2023 |
Journal: |
PLoS One |
Title: |
Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice. |
Volume: |
18 |
Issue: |
4 |
Pages: |
e0284327 |
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Publication |
First Author: |
Waga C |
Year: |
2014 |
Journal: |
J Neurochem |
Title: |
Identification of two novel Shank3 transcripts in the developing mouse neocortex. |
Volume: |
128 |
Issue: |
2 |
Pages: |
280-93 |
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Publication |
First Author: |
Gregory RI |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. |
Volume: |
21 |
Issue: |
16 |
Pages: |
5426-36 |
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Publication |
First Author: |
Amir RE |
Year: |
1999 |
Journal: |
Nat Genet |
Title: |
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. |
Volume: |
23 |
Issue: |
2 |
Pages: |
185-8 |
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Publication |
First Author: |
Hutchison ER |
Year: |
2013 |
Journal: |
Glia |
Title: |
Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. |
Volume: |
61 |
Issue: |
7 |
Pages: |
1018-28 |
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•
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Publication |
First Author: |
Coutelle O |
Year: |
1998 |
Journal: |
Gene |
Title: |
The neural cell adhesion molecule L1: genomic organisation and differential splicing is conserved between man and the pufferfish Fugu. |
Volume: |
208 |
Issue: |
1 |
Pages: |
7-15 |
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