Type |
Details |
Score |
Publication |
First Author: |
Scherz-Shouval R |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A. |
Volume: |
278 |
Issue: |
16 |
Pages: |
14053-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakatogawa H |
Year: |
2009 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
Dynamics and diversity in autophagy mechanisms: lessons from yeast. |
Volume: |
10 |
Issue: |
7 |
Pages: |
458-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Z |
Year: |
2010 |
Journal: |
Nat Cell Biol |
Title: |
Eaten alive: a history of macroautophagy. |
Volume: |
12 |
Issue: |
9 |
Pages: |
814-22 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Autophagin-2 (ATG4A, MEROPS identifier C54.002) is a cysteine endopeptidase required for autophagy, an intracellular degradation system found only in eukaryotes [, ]. Once induced, double membrane-bound vesicles called autophagosomes engulf cytoplasm, even whole organelles and invading bacteria, and deliver them to the lysosome for degradation. Autophagins cleave proteins required for autophagosome development, such as gamma-aminobutyric acid receptor-associated protein (GABARAP), gamma-aminobutyric acid receptor-associated protein-like 2 (GATE-16), and microtubule-associated protein light chain 3 (LC3). GABARAP and GATE-16 seem to be better substrates than LC3B for ATG4A [, , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Whang MI |
Year: |
2017 |
Journal: |
Immunity |
Title: |
The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. |
Volume: |
46 |
Issue: |
3 |
Pages: |
405-420 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chino H |
Year: |
2019 |
Journal: |
Mol Cell |
Title: |
Intrinsically Disordered Protein TEX264 Mediates ER-phagy. |
Volume: |
74 |
Issue: |
5 |
Pages: |
909-921.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saito T |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Autophagy regulates lipid metabolism through selective turnover of NCoR1. |
Volume: |
10 |
Issue: |
1 |
Pages: |
1567 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamuro T |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. |
Volume: |
11 |
Issue: |
1 |
Pages: |
4150 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang D |
Year: |
2022 |
Journal: |
Adv Sci (Weinh) |
Title: |
Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy. |
Volume: |
9 |
Issue: |
3 |
Pages: |
e2102568 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura T |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking. |
Volume: |
7 |
|
Pages: |
10861 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vernier-Magnin S |
Year: |
2001 |
Journal: |
Biochem Biophys Res Commun |
Title: |
A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP. |
Volume: |
284 |
Issue: |
1 |
Pages: |
118-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pocanschi CL |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Structural and functional relationships between the lectin and arm domains of calreticulin. |
Volume: |
286 |
Issue: |
31 |
Pages: |
27266-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mizokami A |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. |
Volume: |
27 |
Issue: |
7 |
Pages: |
1692-701 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanematsu T |
Year: |
2002 |
Journal: |
EMBO J |
Title: |
Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. |
Volume: |
21 |
Issue: |
5 |
Pages: |
1004-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
McMillan P |
Year: |
2020 |
Journal: |
Acta Neuropathol Commun |
Title: |
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang G |
Year: |
2023 |
Journal: |
Cell Death Differ |
Title: |
Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice. |
Volume: |
30 |
Issue: |
2 |
Pages: |
500-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kneussel M |
Year: |
2002 |
Journal: |
Brain Res Brain Res Rev |
Title: |
Dynamic regulation of GABA(A) receptors at synaptic sites. |
Volume: |
39 |
Issue: |
1 |
Pages: |
74-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Asano S |
Year: |
2014 |
Journal: |
Biol Open |
Title: |
Phospholipase C-related catalytically inactive protein (PRIP) controls KIF5B-mediated insulin secretion. |
Volume: |
3 |
Issue: |
6 |
Pages: |
463-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Szalai P |
Year: |
2015 |
Journal: |
Exp Cell Res |
Title: |
Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs. |
Volume: |
333 |
Issue: |
1 |
Pages: |
21-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee SE |
Year: |
2023 |
Journal: |
Cells Dev |
Title: |
Cell starvation regulates ceramide-induced autophagy in mouse preimplantation embryo development. |
Volume: |
175 |
|
Pages: |
203859 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xin Y |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. |
Volume: |
74 |
Issue: |
3 |
Pages: |
408-13 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
213
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
372
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
|
Fragment?: |
false |
|
•
•
•
•
•
|