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Search results 5101 to 5200 out of 7122 for App

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Publication
26923602 | J:234359
First Author: Ben Halima S
Year: 2016
Journal: Cell Rep
Title: Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
Volume: 14
Issue: 9
Pages: 2127-2141
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Publication
31564637 | J:279996
First Author: Burr ML
Year: 2019
Journal: Cancer Cell
Title: An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer.
Volume: 36
Issue: 4
Pages: 385-401.e8
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Publication
31353263 | J:283689
First Author: Tyshkovskiy A
Year: 2019
Journal: Cell Metab
Title: Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.
Volume: 30
Issue: 3
Pages: 573-593.e8
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Publication
37923712 | J:342390
First Author: Nithianandam V
Year: 2023
Journal: Nat Commun
Title: Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging.
Volume: 14
Issue: 1
Pages: 7034
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Protein
A0A494BAU6
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
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Protein
Q3TEP8
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: false
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Protein
A0A087WQ58
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
Q80Y77
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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Protein
Q9R021
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
Q8R1Y7
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: true
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Protein
A0A1B0GRP5
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: false
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Protein
Q8BSK4
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein
Q3T9N0
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
A0A1B0GR67
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
A0A1B0GSI3
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
A0A494B9D6
Organism: Mus musculus/domesticus
Length: 63  
Fragment?: true
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Protein
A0A1B0GT76
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: true
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Protein
A0A087WQC5
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
A0A087WPF4
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Publication
16764936 | -
First Author: Rogelj B
Year: 2006
Journal: Brain Res Rev
Title: The X11/Mint family of adaptor proteins.
Volume: 52
Issue: 2
Pages: 305-15
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Publication
11714751 | J:72761
First Author: Zhao H
Year: 2001
Journal: J Exp Med
Title: Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice.
Volume: 194
Issue: 10
Pages: 1441-8
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Publication
22567163 | -
First Author: Yang K
Year: 2012
Journal: PLoS One
Title: DR6 as a diagnostic and predictive biomarker in adult sarcoma.
Volume: 7
Issue: 5
Pages: e36525
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Publication
9714541 | -
First Author: Pan G
Year: 1998
Journal: FEBS Lett
Title: Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.
Volume: 431
Issue: 3
Pages: 351-6
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Publication
23084432 | -
First Author: Qiu CW
Year: 2012
Journal: Med Hypotheses
Title: A new therapy for the reduction of axon and neuron loss and promotion of axon and oligodendrocyte regeneration through inhibition of death receptor 6 pathway after ischemic cerebral stroke.
Volume: 79
Issue: 6
Pages: 853-5
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Protein Domain
IPR034034 | TNFRSF21_N
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor 6 (DR6), CD358, or BM-018, is highly expressed in differentiating neurons as well as in the adult brain, and is upregulated in injured neurons []. DR6 negatively regulates neuron, axon, and oligodendrocyte survival, hinders axondendrocyte and oligodendrocyte regeneration and its inhibition has a neuro-protective effect in nerve injury []. It activates nuclear factor kappa-B (NFkB) and mitogen-activated protein kinase 8 (MAPK8, also called c-Jun N-terminal kinase 1), and induces cell apoptosis by associating with TNFRSF1A-associated via death domain (TRADD), which is known to mediate signal transduction of tumor necrosis factor receptors []. TNFRSF21 plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation []. It binds alpha-amyloid precursor protein (APP); when released, APP binds in an autocrine/paracrine manner to activate a caspase-dependent self-destruction program that removes unnecessary or connectionless axons []. Increasing beta-catenin levels in brain endothelium upregulates TNFRSF21 and TNFRSF19, indicating that these death receptors are downstream target genes of Wnt/beta-catenin signaling, which has been shown to be required for blood-brain barrier development []. DR6 is up-regulated in numerous solid tumors as well as in tumor vascular cells, including ovarian cancer and may be a clinically useful diagnostic and predictive serum biomarker for some adult sarcoma subtypes [].This entry represents the N-terminal domain of TNFRSF21. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].
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Protein Coding Gene
MGI:1309517 | Itm2b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0019501 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:88047 | Aplp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0031937 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021557 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0034517 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021516 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034495 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021492 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021522 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034486 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021299 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034198 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1309517 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034172 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021390 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034329 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021460 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034415 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021397 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034316 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020870 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014802 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_PahariEiJ_G0030518 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020395 | -
Type: protein_coding_gene
Organism: Mus spretus
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Protein Coding Gene
MGP_SPRETEiJ_G0033060 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8218408 | J:15454
First Author: Hanes J
Year: 1993
Journal: Biochim Biophys Acta
Title: The complete cDNA coding sequence for the mouse CDEI binding protein.
Volume: 1216
Issue: 1
Pages: 154-6
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Publication
9795190 | J:50094
First Author: Pittois K
Year: 1998
Journal: Gene
Title: cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B.
Volume: 217
Issue: 1-2
Pages: 141-9
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Publication
9707424 | J:49466
First Author: Rassoulzadegan M
Year: 1998
Journal: EMBO J
Title: APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells.
Volume: 17
Issue: 16
Pages: 4647-56
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Publication
26313004 | J:228923
First Author: Tkatchenko AV
Year: 2015
Journal: PLoS Genet
Title: APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.
Volume: 11
Issue: 8
Pages: e1005432
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Publication
30890756 | J:275613
First Author: Yao W
Year: 2019
Journal: Sci Rep
Title: The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms.
Volume: 9
Issue: 1
Pages: 4862
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Publication
21098268 | J:167154
First Author: Tamayev R
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits.
Volume: 107
Issue: 48
Pages: 20822-7
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Publication
21048150 | J:166696
First Author: Tamayev R
Year: 2010
Journal: J Neurosci
Title: Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
Volume: 30
Issue: 44
Pages: 14915-24
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Publication
1766880 | J:30522
First Author: Blangy A
Year: 1991
Journal: Nucleic Acids Res
Title: Recognition of the CDEI motif GTCACATG by mouse nuclear proteins and interference with the early development of the mouse embryo.
Volume: 19
Issue: 25
Pages: 7243-50
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Publication
8086458 | J:20405
First Author: Sandbrink R
Year: 1994
Journal: Biochim Biophys Acta
Title: Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues.
Volume: 1219
Issue: 1
Pages: 167-70
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Publication
16612985 | J:140082
First Author: Pickford F
Year: 2006
Journal: Brain Pathol
Title: Modeling familial British dementia in transgenic mice.
Volume: 16
Issue: 1
Pages: 80-5
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Publication
18440095 | J:156660
First Author: Tsachaki M
Year: 2010
Journal: Neurobiol Aging
Title: BRI2 homodimerizes with the involvement of intermolecular disulfide bonds.
Volume: 31
Issue: 1
Pages: 88-98
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Publication
24026677 | J:204507
First Author: Audo I
Year: 2014
Journal: Hum Mol Genet
Title: The familial dementia gene revisited: a missense mutation revealed by whole-exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family.
Volume: 23
Issue: 2
Pages: 491-501
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GXD Expression
GXD Expression
 
Probe: MGI:4884696
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4944813
Age: embryonic day 11.5
Image: g00235 E11.5
Specimen Label: g00235 E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4884696
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4944813
Age: embryonic day 15.5
Image: g00235 E15.5
Specimen Label: g00235 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1397682
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825745
Age: embryonic day 14.5
Image: Additional file 4 Itm2b
Specimen Label: Additional file 4 Itm2b
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4884696
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4944813
Age: embryonic day 15.5
Image: g00235 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00235 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_02
Specimen Label: euxassay_004667_02
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_03
Specimen Label: euxassay_004667_03
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_04
Specimen Label: euxassay_004667_04
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_05
Specimen Label: euxassay_004667_05
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_17
Specimen Label: euxassay_004667_17
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_18
Specimen Label: euxassay_004667_18
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_19
Specimen Label: euxassay_004667_19
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:4884696
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4944813
Age: postnatal day 7
Image: g00235 P7
Specimen Label: g00235 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4884696
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4944813
Age: embryonic day 11.5
Image: g00235 E11.5
Specimen Label: g00235 E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4884696
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4944813
Age: embryonic day 15.5
Image: g00235 E15.5
Specimen Label: g00235 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4884696
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4944813
Age: postnatal day 7
Image: g00235 P7
Specimen Label: g00235 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1816623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_03
Specimen Label: euxassay_004667_03
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1816623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_04
Specimen Label: euxassay_004667_04
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1816623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_05
Specimen Label: euxassay_004667_05
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1816623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_18
Specimen Label: euxassay_004667_18
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1816623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_19
Specimen Label: euxassay_004667_19
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1816623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_20
Specimen Label: euxassay_004667_20
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2002020
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1816623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823180
Age: embryonic day 14.5
Image: euxassay_004667_21
Specimen Label: euxassay_004667_21
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4884696
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4944813
Age: embryonic day 15.5
Image: g00235 E15.5
Specimen Label: g00235 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•




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