Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
MURC (also known as cavin 4) is a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway []. It plays a role in hypoxia-induced hypertrophy in cardiomyocytes []. It is involved in membrane trafficking of caveolin-3 in cardiomyocytes []. Fish have two murc genes (murca and murcb) []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Naito D |
Year: |
2015 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes. |
Volume: |
309 |
Issue: |
12 |
Pages: |
H2127-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogata T |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. |
Volume: |
28 |
Issue: |
10 |
Pages: |
3424-36 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
362
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Shyu KG |
Year: |
2014 |
Journal: |
Clin Sci (Lond) |
Title: |
Hypoxia activates muscle-restricted coiled-coil protein (MURC) expression via transforming growth factor-β in cardiac myocytes. |
Volume: |
126 |
Issue: |
5 |
Pages: |
367-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Housley MP |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Cavin4b/Murcb Is Required for Skeletal Muscle Development and Function in Zebrafish. |
Volume: |
12 |
Issue: |
6 |
Pages: |
e1006099 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogata T |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors. |
Volume: |
111 |
Issue: |
10 |
Pages: |
3811-6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Brain |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Heart |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1860128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Aorta |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3598828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Skeletal muscle |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Stomach |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Lung |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Kidney |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Liver |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Spleen |
Detected: |
false |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317451 |
Assay Type: |
Northern blot |
Annotation Date: |
2012-05-08 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317452 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Testis |
Detected: |
false |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317449 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5317551 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317449 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5317553 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317449 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610521 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5317553 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
E13.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317449 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610523 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5317553 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
E15.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317449 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610525 |
|
Stage: |
TS25 |
Assay Id: |
MGI:5317553 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
E17.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317449 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:5317553 |
Age: |
postnatal newborn |
|
|
Specimen Label: |
Neonate |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317449 |
Assay Type: |
RT-PCR |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317553 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Adult |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Western blot |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317559 |
Age: |
postnatal |
|
|
Specimen Label: |
NTg |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Western blot |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317559 |
Age: |
postnatal |
|
|
Specimen Label: |
NTg |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Western blot |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317559 |
Age: |
postnatal |
|
|
Specimen Label: |
NTg |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5317453 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5317453 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3B top |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5317453 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3B bottom |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5317453 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3C top |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-05-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5317453 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3C bottom |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-05-08 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3517628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5317453 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3A |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5317448 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2012-05-08 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3517728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5317453 |
Age: |
postnatal adult |
|
|
Specimen Label: |
3A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bastiani M |
Year: |
2009 |
Journal: |
J Cell Biol |
Title: |
MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. |
Volume: |
185 |
Issue: |
7 |
Pages: |
1259-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakanishi N |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
MURC deficiency in smooth muscle attenuates pulmonary hypertension. |
Volume: |
7 |
|
Pages: |
12417 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyagawa K |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm. |
Volume: |
487 |
Issue: |
3 |
Pages: |
587-593 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ludwig A |
Year: |
2013 |
Journal: |
PLoS Biol |
Title: |
Molecular composition and ultrastructure of the caveolar coat complex. |
Volume: |
11 |
Issue: |
8 |
Pages: |
e1001640 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bang ML |
Year: |
2017 |
Journal: |
J Cell Physiol |
Title: |
Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins. |
Volume: |
232 |
Issue: |
1 |
Pages: |
38-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
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