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Search results 801 to 900 out of 900 for Hdac2

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Type Details Score
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Protein Domain
Type: Domain
Description: This entry represents a domain found in DNA methyltransferase 1-associated protein 1 (DMAP1). DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic N terminus of DNMT1 binds to HDAC2 and DMAP1, and can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase, providing a platform for how histones may become deacetylated in heterochromatin following replication [].
Publication
First Author: Corona M
Year: 1991
Journal: Anat Histol Embryol
Title: [The sensitive nerve endings of the clitoris of the sow (Sus scrofa domesticus)].
Volume: 20
Issue: 4
Pages: 369-77
Publication
First Author: Syeda F
Year: 2011
Journal: J Biol Chem
Title: The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
Volume: 286
Issue: 17
Pages: 15344-51
Protein Domain
Type: Domain
Description: This domain is part of a cytosine specific DNA methyltransferase enzyme (DNMT). It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties [].A structure exists for the human cytosine specific DNA methyltransferase replication foci domain [].
Protein Domain
Type: Family
Description: This entry represents DNA (cytosine-5)-methyltransferase 1 (Dnmt1; ), which methylates CpG residues, with a preference for hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Dnmt1 mediates transcriptional repression (silencing) by establishing a repressive transcription complex where the N terminus of Dnmt1 binds to HDAC2 (histone deacetylase-2) as well as to DMAP1 (Dnmt1-associated protein) []. LSH, which is related to the SNF2 chromatin-remodelling ATPases, is also required for efficient DNA methylation [].
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
GO Term
Publication  
First Author: Kolos JM
Year: 2018
Journal: Front Pharmacol
Title: FKBP Ligands-Where We Are and Where to Go?
Volume: 9
Pages: 1425
Publication
First Author: Yang WM
Year: 2001
Journal: EMBO J
Title: The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1.
Volume: 20
Issue: 17
Pages: 4814-25
Publication
First Author: Zhu W
Year: 2017
Journal: Theranostics
Title: FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27.
Volume: 7
Issue: 12
Pages: 3078-3089
Publication
First Author: Dilworth D
Year: 2017
Journal: Nucleic Acids Res
Title: The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module.
Volume: 45
Issue: 20
Pages: 11989-12004
Protein Domain
Type: Family
Description: FKBP3, also known as FKBP25, contains the N-terminal basic tilted helix bundle (BTHB) domain and the C-terminal PPIase domain. It is a nuclear prolyl isomerase that interacts directlywith nucleic acids []. It interacts with the histone deacetylases HDAC1 and HDAC2 as well as with their transcriptional regulator Yin Yang 1 (YY1) []. It is also a microtubule-associated protein that shuttles between nucleus and cytoplasm and stabilizes the microtubule network by direct binding of the C-terminal PPIase domain []. It plays a role in the proliferation of non-small cell type lung cancer cells (NSCLC) by modulating Sp1/HDAC2/p27 [].
HT Experiment
Series Id: GSE35432
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
Publication
First Author: Yang SH
Year: 2005
Journal: EMBO J
Title: PIASx acts as an Elk-1 coactivator by facilitating derepression.
Volume: 24
Issue: 12
Pages: 2161-71
Protein Domain
Type: Family
Description: SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability []. PIAS2 is an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilising the interaction between Ubc9 and the substrate, and is a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zhang T
Year: 2018
Journal: Nat Commun
Title: A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.
Volume: 9
Issue: 1
Pages: 3798
Publication
First Author: Huang C
Year: 2014
Journal: Cell Rep
Title: The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.
Volume: 8
Issue: 5
Pages: 1497-508
Publication
First Author: Matsui K
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter.
Volume: 440
Issue: 1
Pages: 184-9
Publication
First Author: Tanaka S
Year: 2020
Journal: Nat Immunol
Title: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.
Volume: 21
Issue: 8
Pages: 950-961
Publication
First Author: Kennedy AJ
Year: 2016
Journal: Cell Rep
Title: Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Volume: 16
Issue: 10
Pages: 2666-2685
Publication
First Author: Fukumoto T
Year: 2018
Journal: Cell Rep
Title: Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer.
Volume: 22
Issue: 13
Pages: 3393-3400
Publication  
First Author: Jin X
Year: 2017
Journal: Front Cell Neurosci
Title: Neuronal Nitric Oxide Synthase in Neural Stem Cells Induces Neuronal Fate Commitment via the Inhibition of Histone Deacetylase 2.
Volume: 11
Pages: 66
Publication
First Author: Rosenberg LH
Year: 2018
Journal: Cell Rep
Title: HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State.
Volume: 25
Issue: 10
Pages: 2755-2765.e5
Publication  
First Author: Hosokawa H
Year: 2016
Journal: Nat Commun
Title: Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
Volume: 7
Pages: 11289
Publication
First Author: Rei D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway.
Volume: 112
Issue: 23
Pages: 7291-6
Publication
First Author: Baumann C
Year: 2020
Journal: Nat Commun
Title: Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis.
Volume: 11
Issue: 1
Pages: 4486
Publication
First Author: Liu R
Year: 2009
Journal: Cancer Res
Title: FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus.
Volume: 69
Issue: 6
Pages: 2252-9
Publication
First Author: Zhao Z
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation.
Volume: 107
Issue: 12
Pages: 5605-10
Publication
First Author: Qin L
Year: 2018
Journal: Nat Neurosci
Title: Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition.
Volume: 21
Issue: 4
Pages: 564-575
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zhang Y
Year: 1999
Journal: Genes Dev
Title: Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Volume: 13
Issue: 15
Pages: 1924-35
Publication
First Author: Cong L
Year: 2011
Journal: J Biol Chem
Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.
Volume: 286
Issue: 51
Pages: 43793-808
Publication
First Author: Marinho D
Year: 2023
Journal: Aging Cell
Title: Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease.
Volume: 22
Issue: 8
Pages: e13895
Publication
First Author: Forzati F
Year: 2012
Journal: J Clin Invest
Title: CBX7 is a tumor suppressor in mice and humans.
Volume: 122
Issue: 2
Pages: 612-23
Publication
First Author: Hendrickx A
Year: 2014
Journal: PLoS One
Title: Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease.
Volume: 9
Issue: 6
Pages: e99467
Publication
First Author: Vengoji R
Year: 2021
Journal: J Exp Clin Cancer Res
Title: Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma.
Volume: 40
Issue: 1
Pages: 335
Publication
First Author: Shapson-Coe A
Year: 2019
Journal: PLoS One
Title: Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex.
Volume: 14
Issue: 3
Pages: e0213553
Publication
First Author: Sada N
Year: 2020
Journal: Cell Death Dis
Title: Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury.
Volume: 11
Issue: 8
Pages: 655
Publication
First Author: Zhang H
Year: 2021
Journal: Sci Transl Med
Title: Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis.
Volume: 13
Issue: 614
Pages: eabd1206
Publication
First Author: Nguyen-Tran DH
Year: 2014
Journal: Dis Model Mech
Title: Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.
Volume: 7
Issue: 1
Pages: 41-54
Publication  
First Author: Hsiao YH
Year: 2017
Journal: Neurobiol Learn Mem
Title: Co-housing reverses memory decline by epigenetic regulation of brain-derived neurotrophic factor expression in an animal model of Alzheimer's disease.
Volume: 141
Pages: 1-8
Publication
First Author: Santoro F
Year: 2013
Journal: Blood
Title: A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
Volume: 121
Issue: 17
Pages: 3459-68
Publication  
First Author: Kumar V
Year: 2019
Journal: Front Mol Neurosci
Title: Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model Mouse.
Volume: 12
Pages: 289
Publication
First Author: Backlund MG
Year: 2008
Journal: Cancer Res
Title: Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.
Volume: 68
Issue: 22
Pages: 9331-7
Publication
First Author: Kumar P
Year: 2014
Journal: J Biol Chem
Title: Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-a gene: interactive roles of modified histones, histone acetyltransferase, p300, AND Sp1.
Volume: 289
Issue: 10
Pages: 6991-7002
Publication
First Author: Eom GH
Year: 2014
Journal: Circ Res
Title: Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy.
Volume: 114
Issue: 7
Pages: 1133-43
Publication
First Author: Feng B
Year: 2014
Journal: Diabetes
Title: Mitogen-activated protein kinase phosphatase 3 (MKP-3)-deficient mice are resistant to diet-induced obesity.
Volume: 63
Issue: 9
Pages: 2924-34
Publication
First Author: Schmidt D
Year: 2008
Journal: Exp Cell Res
Title: Blimp-1Deltaexon7: a naturally occurring Blimp-1 deletion mutant with auto-regulatory potential.
Volume: 314
Issue: 20
Pages: 3614-27
Publication
First Author: Khier H
Year: 1999
Journal: Biochim Biophys Acta
Title: Molecular cloning and characterization of the mouse histone deacetylase 1 gene: integration of a retrovirus in 129SV mice.
Volume: 1489
Issue: 2-3
Pages: 365-73
Publication
First Author: Grozinger CM
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Three proteins define a class of human histone deacetylases related to yeast Hda1p.
Volume: 96
Issue: 9
Pages: 4868-73
Publication
First Author: Zupkovitz G
Year: 2006
Journal: Mol Cell Biol
Title: Negative and positive regulation of gene expression by mouse histone deacetylase 1.
Volume: 26
Issue: 21
Pages: 7913-28
Publication
First Author: Xu Z
Year: 2006
Journal: Biochem J
Title: Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors.
Volume: 399
Issue: 2
Pages: 297-304
Publication
First Author: Zhang Y
Year: 2005
Journal: Nucleic Acids Res
Title: The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.
Volume: 33
Issue: 18
Pages: 6024-33
Publication
First Author: Zhang J
Year: 2011
Journal: Genes Dev
Title: Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.
Volume: 25
Issue: 24
Pages: 2610-8
Publication
First Author: Ihlefeld K
Year: 2012
Journal: Biochem J
Title: Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts.
Volume: 447
Issue: 3
Pages: 457-64
Publication
First Author: Hwang-Verslues WW
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy.
Volume: 110
Issue: 30
Pages: 12331-6
Publication
First Author: Desai MA
Year: 2015
Journal: Nucleic Acids Res
Title: An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.
Volume: 43
Issue: 6
Pages: 3100-13
Publication    
First Author: Sleiman SF
Year: 2016
Journal: Elife
Title: Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.
Volume: 5
Publication
First Author: Vilhais-Neto GC
Year: 2017
Journal: Nat Commun
Title: The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry.
Volume: 8
Issue: 1
Pages: 728
Publication
First Author: Srivas S
Year: 2018
Journal: J Neurochem
Title: Transcriptional co-repressor SIN3A silencing rescues decline in memory consolidation during scopolamine-induced amnesia.
Volume: 145
Issue: 3
Pages: 204-216
Publication  
First Author: Nieto-Estevez V
Year: 2021
Journal: Front Mol Neurosci
Title: HDAC1 Regulates Neuronal Differentiation.
Volume: 14
Pages: 815808
Publication
First Author: Zheng X
Year: 2023
Journal: Cancer Res
Title: The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization.
Volume: 83
Issue: 14
Pages: 2345-2357
Publication  
First Author: Ravanelli F
Year: 2023
Journal: Int J Mol Sci
Title: Differential Epigenetic Changes in the Dorsal Hippocampus of Male and Female SAMP8 Mice: A Preliminary Study.
Volume: 24
Issue: 17
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
Publication
First Author: Shinbo Y
Year: 2006
Journal: Cell Death Differ
Title: Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.
Volume: 13
Issue: 1
Pages: 96-108
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Singh VP
Year: 2019
Journal: Reproduction
Title: Oocyte-specific deletion of Hdac8 in mice reveals stage-specific effects on fertility.
Volume: 157
Issue: 3
Pages: 305-316
Publication  
First Author: Zhang M
Year: 2020
Journal: J Mol Cell Cardiol
Title: CaMKII exacerbates heart failure progression by activating class I HDACs.
Volume: 149
Pages: 73-81
Publication
First Author: Bai S
Year: 2005
Journal: Mol Cell Biol
Title: DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2.
Volume: 25
Issue: 2
Pages: 751-66
Publication
First Author: Robertson ED
Year: 2012
Journal: J Cell Sci
Title: ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways.
Volume: 125
Issue: Pt 14
Pages: 3320-32
Publication
First Author: Panikker P
Year: 2018
Journal: J Neurosci
Title: Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition.
Volume: 38
Issue: 19
Pages: 4569-4583
Protein
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1501  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1620  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1619  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1627  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
Publication
First Author: Su HL
Year: 2002
Journal: Gene
Title: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.
Volume: 296
Issue: 1-2
Pages: 65-73
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 565  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory