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Search results 801 to 900 out of 983 for Stat5a

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Type Details Score
Publication
First Author: Guo L
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.
Volume: 106
Issue: 32
Pages: 13463-8
Publication
First Author: Pershouse M
Year: 2000
Journal: Genomics
Title: BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1.
Volume: 69
Issue: 1
Pages: 139-42
Publication
First Author: Copeland NG
Year: 1995
Journal: Genomics
Title: Distribution of the mammalian Stat gene family in mouse chromosomes.
Volume: 29
Issue: 1
Pages: 225-8
Publication
First Author: Moon JH
Year: 2020
Journal: Diabetes
Title: Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.
Volume: 69
Issue: 2
Pages: 205-214
Publication
First Author: Riedelberger M
Year: 2020
Journal: iScience
Title: Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Volume: 23
Issue: 5
Pages: 101121
Publication
First Author: Hirai M
Year: 2017
Journal: J Clin Invest
Title: Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
Volume: 127
Issue: 2
Pages: 569-582
Publication
First Author: Zecchini S
Year: 2019
Journal: Autophagy
Title: Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.
Volume: 15
Issue: 1
Pages: 58-77
Publication
First Author: Chen PC
Year: 2010
Journal: J Clin Invest
Title: Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.
Volume: 120
Issue: 12
Pages: 4353-65
Publication
First Author: Zhang Q
Year: 2021
Journal: Cell Death Dis
Title: Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.
Volume: 12
Issue: 10
Pages: 879
Publication
First Author: Aszodi A
Year: 2003
Journal: Genes Dev
Title: Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Volume: 17
Issue: 19
Pages: 2465-79
Publication
First Author: VanDunk C
Year: 2011
Journal: J Neurosci
Title: Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.
Volume: 31
Issue: 17
Pages: 6457-67
Publication
First Author: Li S
Year: 2016
Journal: Biol Reprod
Title: Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.
Volume: 94
Issue: 2
Pages: 41
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
Publication      
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
Publication  
First Author: Wiese CB
Year: 2012
Journal: Front Neurosci
Title: A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Volume: 6
Pages: 130
Publication
First Author: Guo G
Year: 2010
Journal: Dev Cell
Title: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Volume: 18
Issue: 4
Pages: 675-85
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Gowri PM
Year: 2001
Journal: J Biol Chem
Title: Conversion of threonine 757 to valine enhances Stat5a transactivation potential.
Volume: 276
Issue: 13
Pages: 10485-91
Publication
First Author: Schröder P
Year: 1998
Journal: Biochim Biophys Acta
Title: Cloning and sequencing of the bovine STAT5A cDNA reveals significant sequence divergence with ovine.
Volume: 1398
Issue: 2
Pages: 99-105
HT Experiment
Series Id: GSE17723
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Hennighausen L
Year: 2008
Journal: Genes Dev
Title: Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B.
Volume: 22
Issue: 6
Pages: 711-21
Publication
First Author: Tsuruyama T
Year: 2016
Journal: J Cell Biochem
Title: STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner.
Volume: 117
Issue: 11
Pages: 2630-42
Publication
First Author: Neculai D
Year: 2005
Journal: J Biol Chem
Title: Structure of the unphosphorylated STAT5a dimer.
Volume: 280
Issue: 49
Pages: 40782-7
Publication
First Author: Verdier F
Year: 1998
Journal: Mol Cell Biol
Title: A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.
Volume: 18
Issue: 10
Pages: 5852-60
Interaction Experiment
Description: Proteasome-dependent down-regulation of activated Stat5A in the nucleus.
Interaction Experiment
Description: ERalpha and STAT5a cross-talk: interaction through C-terminal portions of the proteins decreases STAT5a phosphorylation, nuclear translocation and DNA-binding.
Interaction Experiment
Description: PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.
Publication
First Author: Clark DE
Year: 2005
Journal: J Biol Chem
Title: ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.
Volume: 280
Issue: 25
Pages: 24175-80
Allele
Name: signal transducer and activator of transcription 5A; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Cella N
Year: 1998
Journal: Mol Cell Biol
Title: Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells.
Volume: 18
Issue: 4
Pages: 1783-92
Publication
First Author: Wang Y
Year: 2004
Journal: FEBS Lett
Title: ERalpha and STAT5a cross-talk: interaction through C-terminal portions of the proteins decreases STAT5a phosphorylation, nuclear translocation and DNA-binding.
Volume: 572
Issue: 1-3
Pages: 238-44
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: transgene insertion 6, Itamar Barash
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Tg(BLG-STAT5A)6Itb/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Allele
Name: transgene insertion 15, Itamar Barash
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
Allele
Name: signal transducer and activator of transcription 5B; targeted mutation 2, James N Ihle
Allele Type: Targeted
Attribute String: Null/knockout
Publication  
First Author: Eilon T
Year: 2008
Journal: BMC Cancer
Title: Different gene-expression profiles for the poorly differentiated carcinoma and the highly differentiated papillary adenocarcinoma in mammary glands support distinct metabolic pathways.
Volume: 8
Pages: 270
Publication  
First Author: Eilon T
Year: 2009
Journal: BMC Genomics
Title: Distinct gene-expression profiles characterize mammary tumors developed in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5.
Volume: 10
Pages: 231
Genotype
Symbol: Tg(BLG-STAT5A)15Itb/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Publication  
First Author: Heltemes-Harris LM
Year: 2011
Journal: Ann N Y Acad Sci
Title: The role of STAT5 in the development, function, and transformation of B and T lymphocytes.
Volume: 1217
Pages: 18-31
Protein Domain
Type: Domain
Description: This entry represents the SH2 domain of STAT5b.STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a and STAT5b are encoded by separate genes, but are 90% identical at the amino acid level. Both STAT5a and STAT5b are ubiquitously expressed and functionally interchangeable. They regulate B and T cell development [, ].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
Protein Domain
Type: Family
Description: STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a and STAT5b are encoded by separate genes, but are 90% identical at the amino acid level. Both STAT5a and STAT5b are ubiquitously expressed and functionally interchangeable. They regulate B and T cell development [, ].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
Publication
First Author: Snow JW
Year: 2003
Journal: Exp Hematol
Title: Transgenic bcl-2 is not sufficient to rescue all hematolymphoid defects in STAT5A/5B-deficient mice.
Volume: 31
Issue: 12
Pages: 1253-8
Genotype
Symbol: Stat5a/Stat5a Stat5b/Stat5b
Background: either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Stat5a/Stat5a Stat5b/Stat5b
Background: involves: 129 * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Takeda K
Year: 2000
Journal: Cytokine Growth Factor Rev
Title: STAT family of transcription factors in cytokine-mediated biological responses.
Volume: 11
Issue: 3
Pages: 199-207
Publication
First Author: Chen KS
Year: 1996
Journal: Cytogenet Cell Genet
Title: Cloning and chromosomal localization of the rat Stat5 and Yy1 genes.
Volume: 74
Issue: 4
Pages: 277-80
Publication
First Author: Zirngibl RA
Year: 2002
Journal: Mol Cell Biol
Title: Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis.
Volume: 22
Issue: 8
Pages: 2472-86
Publication
First Author: Mandarano AH
Year: 2023
Journal: Cell Rep
Title: DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development.
Volume: 42
Issue: 2
Pages: 112106
Publication
First Author: Dhennin-Duthille I
Year: 2011
Journal: J Biol Chem
Title: The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction.
Volume: 286
Issue: 7
Pages: 5034-42
Publication
First Author: Hiai H
Year: 2003
Journal: Cancer Sci
Title: Pre-B lymphomas in SL/Kh mice: a multifactorial disease model.
Volume: 94
Issue: 10
Pages: 847-50
Publication
First Author: Tsuruyama T
Year: 2017
Journal: Oncogene
Title: Hotspots of MLV integration in the hematopoietic tumor genome.
Volume: 36
Issue: 9
Pages: 1169-1175
Publication
First Author: Hennighausen L
Year: 2020
Journal: Cell Rep
Title: Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy.
Volume: 32
Issue: 13
Pages: 108199
Publication
First Author: Grimm SL
Year: 2002
Journal: Mol Endocrinol
Title: Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.
Volume: 16
Issue: 12
Pages: 2675-91
Publication
First Author: Riedlinger G
Year: 2002
Journal: Biol Reprod
Title: Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary.
Volume: 66
Issue: 2
Pages: 438-44
Publication
First Author: Cohen PA
Year: 2008
Journal: Blood
Title: STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
Volume: 112
Issue: 5
Pages: 1832-43
Publication
First Author: Muraoka-Cook RS
Year: 2006
Journal: Mol Biol Cell
Title: The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.
Volume: 17
Issue: 9
Pages: 4118-29
Publication
First Author: Muraoka-Cook RS
Year: 2009
Journal: Mol Cell Biol
Title: ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.
Volume: 29
Issue: 18
Pages: 4935-48
Publication
First Author: Aoki N
Year: 2002
Journal: Mol Endocrinol
Title: A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus.
Volume: 16
Issue: 1
Pages: 58-69
Publication
First Author: Stegalkina SS
Year: 1999
Journal: J Virol
Title: Transcription originating in the long terminal repeats of the endogenous mouse mammary tumor virus MTV-3 is activated in Stat5a-null mice and picks Up hitchhiking exons.
Volume: 73
Issue: 10
Pages: 8669-76
Publication
First Author: Ji Y
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.
Volume: 112
Issue: 2
Pages: 476-81
Publication
First Author: Boussadia O
Year: 2002
Journal: Mech Dev
Title: E-cadherin is a survival factor for the lactating mouse mammary gland.
Volume: 115
Issue: 1-2
Pages: 53-62
Publication
First Author: Kanagaratham C
Year: 2023
Journal: J Allergy Clin Immunol
Title: IgG:FcγRIIb signals block effector programs of IgE:FcεRI-activated mast cells but spare survival pathways.
Volume: 152
Issue: 2
Pages: 453-468
Publication
First Author: Williams TM
Year: 2006
Journal: Am J Pathol
Title: Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells.
Volume: 169
Issue: 5
Pages: 1784-801
Publication  
First Author: Kim U
Year: 2022
Journal: Int J Mol Sci
Title: Mammary-Enriched Transcription Factors Synergize to Activate the Wap Super-Enhancer for Mammary Gland Development.
Volume: 23
Issue: 19
Publication
First Author: Senis Y
Year: 1999
Journal: Mol Cell Biol
Title: Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis.
Volume: 19
Issue: 11
Pages: 7436-46
Publication
First Author: Luetteke NC
Year: 1999
Journal: Development
Title: Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.
Volume: 126
Issue: 12
Pages: 2739-50
Publication
First Author: Bessette K
Year: 2008
Journal: Blood
Title: A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling.
Volume: 111
Issue: 1
Pages: 344-50
Publication
First Author: Shillingford JM
Year: 2002
Journal: Mol Endocrinol
Title: Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium.
Volume: 16
Issue: 3
Pages: 563-70