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Search results 1801 to 1900 out of 7122 for App

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Type Details Score
Publication
19329229 | J:168288
First Author: Rönnbäck A
Year: 2011
Journal: Neurobiol Aging
Title: Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.
Volume: 32
Issue: 2
Pages: 280-92
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Publication
22197104 | J:188316
First Author: Maesako M
Year: 2012
Journal: Neurobiol Aging
Title: Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice.
Volume: 33
Issue: 5
Pages: 1011.e11-23
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Publication
18986979 | J:146980
First Author: Boissonneault V
Year: 2009
Journal: J Biol Chem
Title: MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.
Volume: 284
Issue: 4
Pages: 1971-81
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Publication
26717550 | J:233614
     
First Author: Hu C
Year: 2015
Journal: J Neurochem
Title: Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch.
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Publication
25457554 | J:219502
First Author: Katsouri L
Year: 2015
Journal: Neurobiol Aging
Title: Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice.
Volume: 36
Issue: 2
Pages: 821-31
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Publication
20595388 | J:166179
First Author: Liang B
Year: 2010
Journal: J Biol Chem
Title: Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
Volume: 285
Issue: 36
Pages: 27737-44
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Publication
31303501 | J:291128
 
First Author: Fan YG
Year: 2019
Journal: EBioMedicine
Title: Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice.
Volume: 45
Pages: 393-407
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Publication
17157415 | J:135007
First Author: Wang L
Year: 2008
Journal: Neurobiol Aging
Title: Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.
Volume: 29
Issue: 3
Pages: 357-67
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Publication
26661166 | J:318355
First Author: Devraj K
Year: 2016
Journal: J Cereb Blood Flow Metab
Title: BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
Volume: 36
Issue: 7
Pages: 1281-94
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Publication
15169864 | J:101980
First Author: Janus C
Year: 2004
Journal: Learn Mem
Title: Search strategies used by APP transgenic mice during navigation in the Morris water maze.
Volume: 11
Issue: 3
Pages: 337-46
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Publication
16990514 | J:113726
First Author: Willem M
Year: 2006
Journal: Science
Title: Control of peripheral nerve myelination by the beta-secretase BACE1.
Volume: 314
Issue: 5799
Pages: 664-6
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Publication
17521929 | J:128856
First Author: Dineley KT
Year: 2007
Journal: Neurobiol Learn Mem
Title: Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice.
Volume: 88
Issue: 2
Pages: 217-24
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Publication
16503402 | J:110285
First Author: Casadesus G
Year: 2006
Journal: Biochim Biophys Acta
Title: Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice.
Volume: 1762
Issue: 4
Pages: 447-52
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Publication
32380752 | J:291917
 
First Author: Maron R
Year: 2020
Journal: Int J Mol Sci
Title: Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration.
Volume: 21
Issue: 9
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Publication
26433932 | J:226837
First Author: Maulik M
Year: 2015
Journal: Hum Mol Genet
Title: APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.
Volume: 24
Issue: 24
Pages: 7132-50
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Publication
29626114 | J:261588
First Author: Chiang ACA
Year: 2018
Journal: J Exp Med
Title: Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice.
Volume: 215
Issue: 5
Pages: 1349-1364
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Publication
30055413 | J:267031
 
First Author: Bearer EL
Year: 2018
Journal: Neurobiol Aging
Title: Alterations of functional circuitry in aging brain and the impact of mutated APP expression.
Volume: 70
Pages: 276-290
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Publication
30795807 | J:285103
First Author: Sri S
Year: 2019
Journal: Acta Neuropathol Commun
Title: Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease.
Volume: 7
Issue: 1
Pages: 25
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Publication
15584902 | J:94803
First Author: Yang HC
Year: 2004
Journal: J Neurochem
Title: Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
Volume: 91
Issue: 6
Pages: 1249-59
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Publication
17255335 | J:117817
First Author: Yamamoto M
Year: 2007
Journal: Am J Pathol
Title: Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.
Volume: 170
Issue: 2
Pages: 680-92
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Publication
22988240 | J:192472
First Author: Hitt B
Year: 2012
Journal: J Biol Chem
Title: β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Volume: 287
Issue: 46
Pages: 38408-25
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Publication
30464338 | J:268163
First Author: Lee MH
Year: 2018
Journal: Nature
Title: Somatic APP gene recombination in Alzheimer's disease and normal neurons.
Volume: 563
Issue: 7733
Pages: 639-645
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Publication
36614115 | J:332612
 
First Author: Zhou X
Year: 2022
Journal: Int J Mol Sci
Title: iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes.
Volume: 24
Issue: 1
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Publication
38311982 | J:345924
First Author: Hong J
Year: 2024
Journal: Glia
Title: PMP2 regulates myelin thickening and ATP production during remyelination.
Volume: 72
Issue: 5
Pages: 885-898
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Publication
36707887 | J:351746
First Author: Ben-Nejma IRH
Year: 2023
Journal: Alzheimers Res Ther
Title: Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis.
Volume: 15
Issue: 1
Pages: 23
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Publication
23649480 | J:329848
First Author: Xia WF
Year: 2013
Journal: J Bone Miner Res
Title: Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine.
Volume: 28
Issue: 10
Pages: 2122-35
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Publication
38941459 | J:350513
First Author: Li C
Year: 2024
Journal: Sci Adv
Title: TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing.
Volume: 10
Issue: 26
Pages: eado1855
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Publication
39256379 | J:358969
First Author: Goettemoeller AM
Year: 2024
Journal: Nat Commun
Title: Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology.
Volume: 15
Issue: 1
Pages: 7918
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Publication
8744399 | J:100979
First Author: Andrä K
Year: 1996
Journal: Neurobiol Aging
Title: Expression of APP in transgenic mice: a comparison of neuron-specific promoters.
Volume: 17
Issue: 2
Pages: 183-90
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Publication
16962684 | J:128046
First Author: Bjelik A
Year: 2007
Journal: Neurochem Int
Title: APP mRNA splicing is upregulated in the brain of biglycan transgenic mice.
Volume: 50
Issue: 1
Pages: 1-4
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Publication
31778772 | J:352855
 
First Author: Wu Z
Year: 2020
Journal: Prog Neurobiol
Title: Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology.
Volume: 185
Pages: 101730
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Publication
28115709 | J:264939
First Author: Netzer WJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage.
Volume: 114
Issue: 6
Pages: 1389-1394
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Publication
24623762 | J:209607
First Author: Born HA
Year: 2014
Journal: J Neurosci
Title: Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.
Volume: 34
Issue: 11
Pages: 3826-40
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Publication
19748705 | J:177819
First Author: Matsuda S
Year: 2011
Journal: Neurobiol Aging
Title: Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles.
Volume: 32
Issue: 8
Pages: 1400-8
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Publication
19225519 | J:146602
First Author: Nikolaev A
Year: 2009
Journal: Nature
Title: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Volume: 457
Issue: 7232
Pages: 981-9
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Publication
22212137 | J:183721
First Author: Zhang M
Year: 2012
Journal: J Neurochem
Title: Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.
Volume: 120
Issue: 6
Pages: 1129-38
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Publication
25100603 | J:215577
First Author: Plucińska K
Year: 2014
Journal: J Neurosci
Title: Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes.
Volume: 34
Issue: 32
Pages: 10710-28
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Publication
8744403 | J:129144
First Author: Ali SM
Year: 1996
Journal: Neurobiol Aging
Title: Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice.
Volume: 17
Issue: 2
Pages: 223-34
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Publication
32865299 | J:313055
First Author: Montesinos J
Year: 2020
Journal: EMBO J
Title: The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking.
Volume: 39
Issue: 20
Pages: e103791
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Publication
24531886 | J:335655
First Author: Umeda T
Year: 2014
Journal: Acta Neuropathol
Title: Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.
Volume: 127
Issue: 5
Pages: 685-98
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Publication
29610518 | J:261936
First Author: Meakin PJ
Year: 2018
Journal: Nat Commun
Title: The beta secretase BACE1 regulates the expression of insulin receptor in the liver.
Volume: 9
Issue: 1
Pages: 1306
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Publication
29311632 | J:260174
First Author: Meakin PJ
Year: 2018
Journal: Sci Rep
Title: Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice.
Volume: 8
Issue: 1
Pages: 55
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Publication
19450683 | J:150433
First Author: Seeger G
Year: 2009
Journal: Neurobiol Dis
Title: FAD-mutation of APP is associated with a loss of its synaptotrophic activity.
Volume: 35
Issue: 2
Pages: 258-63
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Publication
16267225 | J:102728
First Author: Liang X
Year: 2005
Journal: J Neurosci
Title: Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.
Volume: 25
Issue: 44
Pages: 10180-7
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Publication
37909036 | J:342976
     
First Author: Viana da Silva S
Year: 2023
Journal: Neuron
Title: Localized APP expression results in progressive network dysfunction by disorganizing spike timing.
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Publication
19523444 | J:150650
First Author: Killick R
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.
Volume: 386
Issue: 1
Pages: 257-62
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Publication
24431460 | J:205564
First Author: Nenov MN
Year: 2014
Journal: J Neurosci
Title: Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice.
Volume: 34
Issue: 3
Pages: 1028-36
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Publication
7472397 | J:29431
First Author: Thinakaran G
Year: 1995
Journal: J Neurosci
Title: Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis.
Volume: 15
Issue: 10
Pages: 6314-26
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GO Term
GO:0042982 | amyloid precursor protein metabolic process
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Publication
22869680 | J:188345
First Author: Maulik M
Year: 2012
Journal: Hum Mol Genet
Title: Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin.
Volume: 21
Issue: 22
Pages: 4857-75
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Publication
14751770 | J:128645
First Author: Boutajangout A
Year: 2004
Journal: Neurobiol Dis
Title: Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.
Volume: 15
Issue: 1
Pages: 47-60
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Publication
29391027 | J:264995
First Author: Kim W
Year: 2018
Journal: Mol Neurodegener
Title: BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
Volume: 13
Issue: 1
Pages: 6
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Publication
22355745 | J:207280
 
First Author: Cao L
Year: 2012
Journal: Sci Rep
Title: The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease.
Volume: 2
Pages: 231
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Publication
31678156 | J:282311
First Author: Gao J
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease.
Volume: 1866
Issue: 1
Pages: 165580
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Publication
19815012 | J:156614
First Author: Perucho J
Year: 2010
Journal: Exp Neurol
Title: The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice.
Volume: 221
Issue: 1
Pages: 54-67
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Publication
26254735 | J:227674
 
First Author: Giacomini A
Year: 2015
Journal: Neurobiol Dis
Title: Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.
Volume: 82
Pages: 385-396
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Publication
28359846 | J:258976
 
First Author: Stagni F
Year: 2017
Journal: Neurobiol Dis
Title: Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome.
Volume: 103
Pages: 11-23
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Publication
27249364 | J:239910
 
First Author: Beglopoulos V
Year: 2016
Journal: Nat Commun
Title: Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice.
Volume: 7
Pages: 11761
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Publication
26581893 | J:228025
 
First Author: Wang J
Year: 2015
Journal: Nat Commun
Title: TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.
Volume: 6
Pages: 8876
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Publication
35830807 | J:328785
First Author: Bai N
Year: 2022
Journal: Cell Rep
Title: Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice.
Volume: 40
Issue: 2
Pages: 111062
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Publication
29955650 | J:351926
 
First Author: Teich AF
Year: 2018
Journal: Alzheimers Dement (N Y)
Title: Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse.
Volume: 4
Pages: 37-45
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Publication
34757693 | J:351605
First Author: Sawa M
Year: 2022
Journal: Alzheimers Dement
Title: Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model.
Volume: 18
Issue: 6
Pages: 1203-1234
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Publication
21651910 | J:174222
First Author: León-Otegui M
Year: 2011
Journal: FEBS Lett
Title: Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells.
Volume: 585
Issue: 14
Pages: 2255-62
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Publication
23897889 | J:201637
First Author: Fu MM
Year: 2013
Journal: J Cell Biol
Title: JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors.
Volume: 202
Issue: 3
Pages: 495-508
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Publication
24810883 | J:214104
 
First Author: Jin G
Year: 2014
Journal: Neurosci Lett
Title: Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice.
Volume: 573
Pages: 58-63
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Publication
27072891 | J:240851
 
First Author: Sun M
Year: 2016
Journal: Neurobiol Dis
Title: The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb.
Volume: 93
Pages: 1-11
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Publication
29728560 | J:263719
First Author: Nagata K
Year: 2018
Journal: Nat Commun
Title: Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology.
Volume: 9
Issue: 1
Pages: 1800
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Publication
24373968 | J:207508
First Author: Ye X
Year: 2014
Journal: Cell Rep
Title: Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons.
Volume: 6
Issue: 1
Pages: 24-31
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Publication
21514441 | J:171581
First Author: Lord A
Year: 2011
Journal: Am J Pathol
Title: Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.
Volume: 178
Issue: 5
Pages: 2286-98
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Publication
33412147 | J:307759
 
First Author: Liu M
Year: 2021
Journal: Brain Res
Title: Covert strokes prior to Alzheimer's disease onset accelerate peri-lesional pathology but not cognitive deficits in an inducible APP mouse model.
Volume: 1754
Pages: 147233
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Publication
18192084 | J:152959
First Author: Philipson O
Year: 2009
Journal: Neurobiol Aging
Title: A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.
Volume: 30
Issue: 9
Pages: 1393-405
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Protein Coding Gene
MGP_CAROLIEiJ_G0032148 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034741 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034722 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034649 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1346542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033746 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034555 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015018 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033287 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
27791018 | J:238803
First Author: Katsouri L
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.
Volume: 113
Issue: 43
Pages: 12292-12297
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Publication
20505099 | J:160819
First Author: McAllister C
Year: 2010
Journal: J Neurosci
Title: Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment.
Volume: 30
Issue: 21
Pages: 7326-34
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Publication
26710318 | J:231480
First Author: Kim J
Year: 2016
Journal: J Neurochem
Title: miR-186 is decreased in aged brain and suppresses BACE1 expression.
Volume: 137
Issue: 3
Pages: 436-45
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Publication
17576410 | J:129458
First Author: Kim DY
Year: 2007
Journal: Nat Cell Biol
Title: BACE1 regulates voltage-gated sodium channels and neuronal activity.
Volume: 9
Issue: 7
Pages: 755-64
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