This entry represents the minimal domain at the C terminus of BCOR (BCL6 corepressor) that is needed for binding specifically to some of the PCGF proteins (polycomb-group RING finger homologues). Because of the selective binding, this domain has been named PCGF Ub-like fold discriminator (PUFD). PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF, PCGF1. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologues whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health [].
The PUFD (PCGF Ub-like fold discriminator) domain is found at the C terminus of BCOR (BCL6 corepressor), and binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the polycomb-group protein PCGF1 []. This domain is also found in BCORL1 (BCL6 corepressor-like), which also binds PCGF1 through its PUFD domain []. Like BCOR, BCORL1 functions as a corepressor [].
