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Search results 1 to 100 out of 206 for Madd

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0.041s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: MAP kinase-activating death domain protein (MADD) regulates cell proliferation, survival and death through alternative mRNA splicing. Different isoforms have different effects: isoform 5 increases cell proliferation whereas isoform 2 decreases it; isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant []. MADD activates RAB3A, RAB3C and RAB3D by converting them from GDP-bound inactive forms to GTP-bound active forms []. MADD is a component of the TNFRSF1A signaling complex, linking the type 1 tumor necrosis factor receptor TNFRSF1A with MAP kinase activation []. MADD contains a tripartite DENN domain. In the nematode Caenorhabditis elegans, MADD is also known as regulator of presynaptic activity aex-3 [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
Gene
Type: gene
Organism: human
Publication
First Author: Efimova EV
Year: 2004
Journal: Oncogene
Title: IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs.
Volume: 23
Issue: 5
Pages: 1076-87
Publication
First Author: Schievella AR
Year: 1997
Journal: J Biol Chem
Title: MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase.
Volume: 272
Issue: 18
Pages: 12069-75
Publication
First Author: Iwasaki K
Year: 1997
Journal: Neuron
Title: aex-3 encodes a novel regulator of presynaptic activity in C. elegans.
Volume: 18
Issue: 4
Pages: 613-22
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
Publication
First Author: Yoshimura S
Year: 2010
Journal: J Cell Biol
Title: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
Volume: 191
Issue: 2
Pages: 367-81
Protein
Organism: Mus musculus/domesticus
Length: 1577  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1627  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1602  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1574  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1577  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1562  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1632  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1573  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1541  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1558  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1115  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1554  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1593  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1475  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Yamaguchi K
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.
Volume: 99
Issue: 22
Pages: 14536-41
Publication
First Author: Li LC
Year: 2014
Journal: Diabetes
Title: IG20/MADD plays a critical role in glucose-induced insulin secretion.
Volume: 63
Issue: 5
Pages: 1612-23
Publication
First Author: Lim KM
Year: 2004
Journal: Int J Cancer
Title: Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle.
Volume: 109
Issue: 1
Pages: 24-37
Publication
First Author: Lewis MA
Year: 2023
Journal: PLoS Genet
Title: Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss.
Volume: 19
Issue: 11
Pages: e1011058
GXD Expression    
Probe: MGI:5640708
Assay Type: RT-PCR
Annotation Date: 2015-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3647224
Stage: TS24
Assay Id: MGI:5640801
Age: embryonic day 16.5
Image: S5
Specimen Label: bv/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5640708
Assay Type: RT-PCR
Annotation Date: 2015-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3647224
Stage: TS24
Assay Id: MGI:5640801
Age: embryonic day 16.5
Image: S5
Specimen Label: bv/bv
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5640709
Assay Type: RT-PCR
Annotation Date: 2015-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3647224
Stage: TS24
Assay Id: MGI:5640829
Age: embryonic day 16.5
Image: S5
Specimen Label: bv/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5640709
Assay Type: RT-PCR
Annotation Date: 2015-06-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3647224
Stage: TS24
Assay Id: MGI:5640829
Age: embryonic day 16.5
Image: S5
Specimen Label: bv/bv
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5640708
Assay Type: RT-PCR
Annotation Date: 2015-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5641076
Age: postnatal day 15
Image: S7
Specimen Label: bv/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5640708
Assay Type: RT-PCR
Annotation Date: 2015-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5641076
Age: postnatal day 15
Image: S7
Specimen Label: bv/bv
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7542983
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284226
Stage: TS26
Assay Id: MGI:7543227
Age: embryonic day 19.0
Image: S4
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7542983
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284226
Stage: TS26
Assay Id: MGI:7543227
Age: embryonic day 19.0
Image: S4
Specimen Label: dMut
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7542984
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284226
Stage: TS26
Assay Id: MGI:7543228
Age: embryonic day 19.0
Image: S4
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7542984
Assay Type: RT-PCR
Annotation Date: 2023-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284226
Stage: TS26
Assay Id: MGI:7543228
Age: embryonic day 19.0
Image: S4
Specimen Label: dMut
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3609873
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3610112
Age: embryonic day 14.5
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3609873
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3610112
Age: embryonic day 16.5
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_01
Specimen Label: euxassay_012746_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_01
Specimen Label: euxassay_012746_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_02
Specimen Label: euxassay_012746_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_02
Specimen Label: euxassay_012746_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_03
Specimen Label: euxassay_012746_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_03
Specimen Label: euxassay_012746_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_04
Specimen Label: euxassay_012746_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_04
Specimen Label: euxassay_012746_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_04
Specimen Label: euxassay_012746_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_05
Specimen Label: euxassay_012746_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_05
Specimen Label: euxassay_012746_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_05
Specimen Label: euxassay_012746_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_06
Specimen Label: euxassay_012746_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_06
Specimen Label: euxassay_012746_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_06
Specimen Label: euxassay_012746_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_07
Specimen Label: euxassay_012746_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_07
Specimen Label: euxassay_012746_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_07
Specimen Label: euxassay_012746_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_07
Specimen Label: euxassay_012746_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_07
Specimen Label: euxassay_012746_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_08
Specimen Label: euxassay_012746_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_08
Specimen Label: euxassay_012746_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_08
Specimen Label: euxassay_012746_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_08
Specimen Label: euxassay_012746_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_09
Specimen Label: euxassay_012746_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_09
Specimen Label: euxassay_012746_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_09
Specimen Label: euxassay_012746_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_09
Specimen Label: euxassay_012746_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1843823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_09
Specimen Label: euxassay_012746_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_09
Specimen Label: euxassay_012746_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_10
Specimen Label: euxassay_012746_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_10
Specimen Label: euxassay_012746_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4417138
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826055
Age: embryonic day 14.5
Image: euxassay_012746_10
Specimen Label: euxassay_012746_10
Detected: true
Specimen Num: 10