Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein have no obvious structural motifs. It is, however, where it binds to Nup98; one of the components of the nuclear pore. The C-terminal end is a predicted coiled-coil domain []. Nup88 is over expressed in tumour cells [].
This entry include a nucleoporin known as NUP88 in animals and NUP82 in yeasts. NUP88 is a component of the nuclear pore complex (NPC), which is the only means by which macromolecules enter and exit the nucleus []. NUP82 is also a component of the NPC subcomplex (with NUP159 and NSP1) which tethers nucleoporins to the nuclear membrane [].
