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Search results 1901 to 1985 out of 1985 for Msx2

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0.03s

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Msx2-cre)5Rem/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2 Rbpj/Rbpj Tg(Msx2-cre)5Rem/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR004181 | Znf_MIZ
Type: Domain
Description: Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents MIZ-type zinc finger domains. Miz1 (Msx-interacting-zinc finger) is a zinc finger-containing protein with homology to the yeast protein, Nfi-1. Miz1 is a sequence specific DNA binding protein that can function as a positive-acting transcription factor. Miz1 binds to the homeobox protein Msx2, enhancing the specific DNA-binding ability of Msx2 []. Other proteins containing this domain include the human pias family (protein inhibitor of activated STAT protein).
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Publication
14623234 | J:86665
First Author: Laurikkala J
Year: 2003
Journal: Dev Biol
Title: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.
Volume: 264
Issue: 1
Pages: 91-105
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Publication
18787189 | J:159796
First Author: Preusch MR
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Critical role of macrophages in glucocorticoid driven vascular calcification in a mouse-model of atherosclerosis.
Volume: 28
Issue: 12
Pages: 2158-64
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Publication
31548378 | J:339378
First Author: Yin Y
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells.
Volume: 116
Issue: 41
Pages: 20528-20538
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Publication
11017806 | J:65555
First Author: Wu YQ
Year: 2000
Journal: Am J Hum Genet
Title: Haploinsufficiency of ALX4 as a potential cause of parietal foramina in the 11p11.2 contiguous gene-deletion syndrome.
Volume: 67
Issue: 5
Pages: 1327-32
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Publication
9073066 | J:60853
First Author: Quinn LM
Year: 1997
Journal: Gene
Title: Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4.
Volume: 187
Issue: 1
Pages: 55-61
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Publication
10095110 | J:53652
First Author: Mohr SE
Year: 1999
Journal: Gene
Title: Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster.
Volume: 229
Issue: 1-2
Pages: 109-16
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Publication
18358468 | J:136062
First Author: Miller KA
Year: 2008
Journal: Dev Biol
Title: Prediction and characterisation of a highly conserved, remote and cAMP responsive enhancer that regulates Msx1 gene expression in cardiac neural crest and outflow tract.
Volume: 317
Issue: 2
Pages: 686-94
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Publication
28912581 | J:255986
First Author: Chovatiya GL
Year: 2017
Journal: Sci Rep
Title: Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response.
Volume: 7
Issue: 1
Pages: 11619
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Publication
19247936 | J:287563
First Author: Mercader N
Year: 2009
Journal: Int J Dev Biol
Title: Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner.
Volume: 53
Issue: 8-10
Pages: 1483-94
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Publication
17098806 | J:356418
First Author: Balbir A
Year: 2007
Journal: Am J Physiol Lung Cell Mol Physiol
Title: A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice.
Volume: 292
Issue: 3
Pages: L704-15
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Publication
12569130 | J:81795
First Author: Barrow JR
Year: 2003
Journal: Genes Dev
Title: Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
Volume: 17
Issue: 3
Pages: 394-409
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Publication
20212115 | J:158689
First Author: Bouldin CM
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning.
Volume: 107
Issue: 12
Pages: 5489-94
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Publication
22377357 | J:184918
First Author: Zhu X
Year: 2012
Journal: Dev Biol
Title: Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis.
Volume: 365
Issue: 2
Pages: 328-38
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Publication
18449196 | J:135198
First Author: Mariani FV
Year: 2008
Journal: Nature
Title: Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning.
Volume: 453
Issue: 7193
Pages: 401-5
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Publication
18359901 | J:136057
First Author: Lu P
Year: 2008
Journal: Development
Title: The apical ectodermal ridge is a timer for generating distal limb progenitors.
Volume: 135
Issue: 8
Pages: 1395-405
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Publication
10802662 | J:61886
First Author: Sun X
Year: 2000
Journal: Nat Genet
Title: Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development.
Volume: 25
Issue: 1
Pages: 83-6
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Publication
18423204 | J:145305
First Author: Wu X
Year: 2008
Journal: Cell
Title: Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.
Volume: 133
Issue: 2
Pages: 340-53
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Publication
15525534 | J:94517
First Author: Pan Y
Year: 2004
Journal: Dev Cell
Title: gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.
Volume: 7
Issue: 5
Pages: 731-43
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Publication
21123569 | J:166744
First Author: Chen J
Year: 2010
Journal: J Neurosci
Title: Channel modulation and the mechanism of light adaptation in mouse rods.
Volume: 30
Issue: 48
Pages: 16232-40
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Publication
21768372 | J:173672
First Author: Barrott JJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.
Volume: 108
Issue: 31
Pages: 12752-7
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Publication
20920500 | J:168038
First Author: Bimonte S
Year: 2011
Journal: Dev Biol
Title: Ofd1 is required in limb bud patterning and endochondral bone development.
Volume: 349
Issue: 2
Pages: 179-91
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Publication
18094024 | J:130854
First Author: Yu K
Year: 2008
Journal: Development
Title: FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.
Volume: 135
Issue: 3
Pages: 483-91
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Publication
19573812 | J:150340
First Author: Demehri S
Year: 2009
Journal: Cancer Cell
Title: Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.
Volume: 16
Issue: 1
Pages: 55-66
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Genotype
Genotype
Symbol: Kif3a/Kif3a Tg(Msx2-cre)5Rem/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr1/Fgfr1 Fgfr2/Fgfr2 Tg(Msx2-rtTA)888Lma/? Tg(tetO-cre)1Jaw/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Msx2-cre/ERT)27Alj/?
Background: involves: 129S4/SvJaeSor * Swiss Webster
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Msx2-cre/ERT2)2Nono/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Msx2-cre/ERT2)1Nono/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
9804809 | J:50962
First Author: Towler DA
Year: 1998
Journal: J Biol Chem
Title: Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice.
Volume: 273
Issue: 46
Pages: 30427-34
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Publication
24632946 | J:210318
First Author: Miyagawa S
Year: 2014
Journal: Cell Death Differ
Title: Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations.
Volume: 21
Issue: 6
Pages: 990-7
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Publication
19699732 | J:153638
First Author: Seo HS
Year: 2009
Journal: Dev Biol
Title: Tgfbr2 is required for development of the skull vault.
Volume: 334
Issue: 2
Pages: 481-90
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Publication
19364479 | J:148696
First Author: Koide Y
Year: 2009
Journal: Biochim Biophys Acta
Title: Embryonic lethality of fortilin-null mutant mice by BMP-pathway overactivation.
Volume: 1790
Issue: 5
Pages: 326-38
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Publication
20493240 | J:165358
First Author: Sun M
Year: 2010
Journal: Neuroscience
Title: The expression of twisted gastrulation in postnatal mouse brain and functional implications.
Volume: 169
Issue: 2
Pages: 920-31
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Publication
9369446 | J:43787
First Author: Sarapura VD
Year: 1997
Journal: Mol Endocrinol
Title: Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter.
Volume: 11
Issue: 12
Pages: 1782-94
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Publication
22074716 | J:177988
First Author: Kostuk EW
Year: 2012
Journal: J Appl Physiol (1985)
Title: Divergent postnatal development of the carotid body in DBA/2J and A/J strains of mice.
Volume: 112
Issue: 3
Pages: 490-500
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Publication
25545010 | J:225380
First Author: Lieven O
Year: 2014
Journal: PLoS One
Title: Differential binding of Lef1 and Msx1/2 transcription factors to Dkk1 CNEs correlates with reporter gene expression in vivo.
Volume: 9
Issue: 12
Pages: e115442
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Publication
24692107 | J:326931
First Author: Kawane T
Year: 2014
Journal: J Bone Miner Res
Title: Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression.
Volume: 29
Issue: 9
Pages: 1960-9
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Publication
20174635 | J:157987
First Author: Dumortier A
Year: 2010
Journal: PLoS One
Title: Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.
Volume: 5
Issue: 2
Pages: e9258
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Publication
15866159 | J:98438
First Author: Huppert SS
Year: 2005
Journal: Dev Cell
Title: Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.
Volume: 8
Issue: 5
Pages: 677-88
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Publication
10837030 | J:62572
First Author: Kimmel RA
Year: 2000
Journal: Genes Dev
Title: Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation.
Volume: 14
Issue: 11
Pages: 1377-89
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Publication
23928991 | J:202618
First Author: Lin C
Year: 2013
Journal: Cancer Res
Title: Constitutive β-catenin activation induces male-specific tumorigenesis in the bladder urothelium.
Volume: 73
Issue: 19
Pages: 5914-25
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Publication
17166921 | J:117033
First Author: Haycraft CJ
Year: 2007
Journal: Development
Title: Intraflagellar transport is essential for endochondral bone formation.
Volume: 134
Issue: 2
Pages: 307-16
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Publication
19906862 | J:154980
First Author: Seifert AW
Year: 2009
Journal: Development
Title: Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development.
Volume: 136
Issue: 23
Pages: 3949-57
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Publication
29752281 | J:276631
 
First Author: Schmidt L
Year: 2018
Journal: Dis Model Mech
Title: Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull.
Volume: 11
Issue: 6
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Publication
17911046 | J:127128
First Author: Rock JR
Year: 2007
Journal: Gene Expr Patterns
Title: Identification of genes expressed in the mouse limb using a novel ZPA microarray approach.
Volume: 8
Issue: 1
Pages: 19-26
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Publication
19211676 | J:146637
First Author: Demehri S
Year: 2009
Journal: Development
Title: Notch signaling in bulge stem cells is not required for selection of hair follicle fate.
Volume: 136
Issue: 6
Pages: 891-6
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Protein
Q8CIE2
Organism: Mus musculus/domesticus
Length: 920  
Fragment?: false
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Publication
26062937 | J:224078
First Author: Liu Z
Year: 2015
Journal: Development
Title: The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.
Volume: 142
Issue: 14
Pages: 2452-63
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Publication
29615464 | J:263988
 
First Author: Gao B
Year: 2018
Journal: Development
Title: Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity.
Volume: 145
Issue: 8
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Publication
35552394 | J:324709
 
First Author: Wang Y
Year: 2022
Journal: Development
Title: The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
Volume: 149
Issue: 9
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Publication
18635608 | J:139251
First Author: Lin C
Year: 2008
Journal: Development
Title: Tissue-specific requirements of beta-catenin in external genitalia development.
Volume: 135
Issue: 16
Pages: 2815-25
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Publication
37453535 | J:358583
 
First Author: Zhu X
Year: 2023
Journal: Ocul Surf
Title: Wnt/β-catenin signaling controls mouse eyelid growth by mediating epithelial-mesenchymal interactions.
Volume: 29
Pages: 486-494
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Publication
32537491 | J:301894
First Author: Delgado I
Year: 2020
Journal: Sci Adv
Title: Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb.
Volume: 6
Issue: 23
Pages: eaaz0742
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Publication
18594511 | J:138578
First Author: Verheyden JM
Year: 2008
Journal: Nature
Title: An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.
Volume: 454
Issue: 7204
Pages: 638-41
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Publication
19386269 | J:149477
First Author: Zhang Z
Year: 2009
Journal: Dev Cell
Title: FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.
Volume: 16
Issue: 4
Pages: 607-13
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Publication
18043734 | J:130369
First Author: Koo BK
Year: 2007
Journal: PLoS One
Title: An obligatory role of mind bomb-1 in notch signaling of mammalian development.
Volume: 2
Issue: 11
Pages: e1221
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Protein
Q91VT1
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
Q6P1E1
Organism: Mus musculus/domesticus
Length: 1072  
Fragment?: false
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Protein
Q3UYT2
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: true
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Protein
A0A2I3BS18
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: false
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Publication
9753686 | J:49912
First Author: Bei M
Year: 1998
Journal: Development
Title: FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development.
Volume: 125
Issue: 21
Pages: 4325-33
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Publication
26457609 | J:227188
   
First Author: Choe Y
Year: 2015
Journal: Elife
Title: Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets.
Volume: 4
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Publication
18507503 | J:139386
First Author: Demehri S
Year: 2008
Journal: PLoS Biol
Title: Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.
Volume: 6
Issue: 5
Pages: e123
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Protein
O88907
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
O54714
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
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Protein
Q9JM05
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q8C5D8
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
Q3U556
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
Q3V2D7
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: true
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Protein
E0CZ31
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
F8WHS8
Organism: Mus musculus/domesticus
Length: 565  
Fragment?: false
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Protein
Q3ULQ6
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q3UGQ2
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q2M4G9
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
G3UWE3
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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Publication
25533675 | J:219292
First Author: Kobayashi T
Year: 2015
Journal: Nat Rev Cancer
Title: Modelling bladder cancer in mice: opportunities and challenges.
Volume: 15
Issue: 1
Pages: 42-54
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Publication
12665246 | -
First Author: Matthews JM
Year: 2002
Journal: IUBMB Life
Title: Zinc fingers--folds for many occasions.
Volume: 54
Issue: 6
Pages: 351-5
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Publication
17210253 | -
First Author: Gamsjaeger R
Year: 2007
Journal: Trends Biochem Sci
Title: Sticky fingers: zinc-fingers as protein-recognition motifs.
Volume: 32
Issue: 2
Pages: 63-70
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Publication
15963892 | -
First Author: Hall TM
Year: 2005
Journal: Curr Opin Struct Biol
Title: Multiple modes of RNA recognition by zinc finger proteins.
Volume: 15
Issue: 3
Pages: 367-73
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Publication
15718139 | -
First Author: Brown RS
Year: 2005
Journal: Curr Opin Struct Biol
Title: Zinc finger proteins: getting a grip on RNA.
Volume: 15
Issue: 1
Pages: 94-8
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Publication
10529348 | -
First Author: Klug A
Year: 1999
Journal: J Mol Biol
Title: Zinc finger peptides for the regulation of gene expression.
Volume: 293
Issue: 2
Pages: 215-8
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Publication
11179890 | -
First Author: Laity JH
Year: 2001
Journal: Curr Opin Struct Biol
Title: Zinc finger proteins: new insights into structural and functional diversity.
Volume: 11
Issue: 1
Pages: 39-46
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom