|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 414 out of 414 for Pik3cg

<< First    < Previous  |  Next >    Last >>
0.017s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
HT Experiment
Series Id: GSE26111
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Strain
Attribute String: congenic, mutant strain, targeted mutation
Genotype
Symbol: Apoe/Apoe Pik3cg/Pik3cg
Background: B6.Cg-Apoe Pik3cg
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Nguyen AH
Year: 2013
Journal: Hum Mol Genet
Title: Gata3 antagonizes cancer progression in Pten-deficient prostates.
Volume: 22
Issue: 12
Pages: 2400-10
Publication
First Author: Pacold ME
Year: 2000
Journal: Cell
Title: Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.
Volume: 103
Issue: 6
Pages: 931-43
Protein Domain
Type: Domain
Description: This entry represents the N-terminal domain of PI3-kinase catalytic subunit gamma (PIK3CG, also known as p110 catalytic subunit gamma). This domain contains the adaptor-binding domain (ABD). PIK3CG interacts with the regulatory subunit of the p101 type [, , ].Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that phosphorylate 4,5-bisphonate (PI(4,5) P2 or PIP2) at the 3-position of the inositol ring, and thus generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which, in turns, initiates a vast array of signaling events. PI3Ks can be grouped into three classes based on their domain organisation. Class I PI3Ks are heterodimers consisting of a p110 catalytic subunit and a regulatory subunit of either the p85 type (associated with the class IA p110 isoforms p110alpha, p110beta or p110delta) or the p101 type (associated with the class IB p110isoform p110gamma). Common to all catalytic subunits are an N-terminal adaptor-binding domain (ABD) that binds to p85/p101, a Ras-binding domain (RBD), a putative membrane-binding domain (C2), a helical domain of unknown function, and a kinase catalytic domain [, , ].PI3K_ABD is a small globular domain of about 100 residues in length with an alpha/β-sandwich topology [, , ].
Genotype
Symbol: Pik3cg/Pik3cg Tg(TcraTcrb)1100Mjb/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Berndt A
Year: 2010
Journal: Nat Chem Biol
Title: The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Volume: 6
Issue: 2
Pages: 117-24
Publication
First Author: Miled N
Year: 2007
Journal: Science
Title: Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.
Volume: 317
Issue: 5835
Pages: 239-42
Publication
First Author: Huang CH
Year: 2007
Journal: Science
Title: The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Volume: 318
Issue: 5857
Pages: 1744-8
Protein
Organism: Mus musculus/domesticus
Length: 1113  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1102  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1024  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1102  
Fragment?: false