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Search results 2301 to 2400 out of 2462 for Gli3

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Gli3/Gli3<+> Scrib/Scrib
Background: involves: C57BL/6J * NMRI
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2
Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli1/Gli1 Gli2/Gli2
Background: involves: 129S6/SvEvTac * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3
Background: involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli1/Gli1<+> Gli2/Gli2 Gli3/Gli3
Background: involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J * NMRI
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+> Rr26/Rr26
Background: involves: 129X1/SvJ * C3H/HeJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+> Rr26/Rr26<+>
Background: involves: 129X1/SvJ * C3H/HeJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdk20/Cdk20 Gli3/Gli3
Background: involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdk20/Cdk20 Gli3/Gli3<+>
Background: involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3 Tg(COL2A1-cre)1Wag/?
Background: involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6J * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: C3H/HeJ * C57BL/6 * Jcl:ICR
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Rab23/Rab23
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 129P2/OlaHsd * C3H * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+> Neo1/Neo1
Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Neo1/Neo1
Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ezh2/Ezh2 Gli3/Gli3 Tg(T-cre)1Lwd/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Arl13b/Arl13b Gli3/Gli3
Background: involves: C3H * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3 Ptch1/Ptch1<+>
Background: involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * CBA/H * CD-1
Zygosity: cx
Has Mutant Allele: true
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Protein
Q0VGT2
Organism: Mus musculus/domesticus
Length: 1544  
Fragment?: false
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Protein
Q8K1M4
Organism: Mus musculus/domesticus
Length: 789  
Fragment?: false
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Protein
Q0VGV1
Organism: Mus musculus/domesticus
Length: 1540  
Fragment?: false
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Protein
H6WAT1
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Protein
B1ASP5
Organism: Mus musculus/domesticus
Length: 601  
Fragment?: false
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Protein Coding Gene
MGI:1891829 | Rbx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97592 | Prkaca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62878
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
P05132
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Publication
25644602 | J:218232
First Author: Chong YC
Year: 2015
Journal: Genes Dev
Title: Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.
Volume: 29
Issue: 3
Pages: 262-76
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Publication
19000668 | J:143544
First Author: Cortellino S
Year: 2009
Journal: Dev Biol
Title: Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.
Volume: 325
Issue: 1
Pages: 225-37
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Publication
29659575 | J:262053
First Author: Tan Z
Year: 2018
Journal: PLoS Genet
Title: Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.
Volume: 14
Issue: 4
Pages: e1007346
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Publication
35173529 | J:321568
First Author: Wu J
Year: 2022
Journal: Int J Biol Sci
Title: A Sonic Hedgehog-Gli-Bmi1 signaling pathway plays a critical role in p27 deficiency induced bone anabolism.
Volume: 18
Issue: 3
Pages: 956-969
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Publication
29109083 | J:293087
First Author: Sheybani-Deloui S
Year: 2018
Journal: J Am Soc Nephrol
Title: Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.
Volume: 29
Issue: 2
Pages: 532-544
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Publication
19056373 | J:145182
First Author: Pan Y
Year: 2009
Journal: Dev Biol
Title: Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development.
Volume: 326
Issue: 1
Pages: 177-89
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Publication
24276242 | J:216560
First Author: Rajurkar M
Year: 2014
Journal: Oncogene
Title: Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis.
Volume: 33
Issue: 46
Pages: 5370-8
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Publication
25356765 | J:228853
First Author: Hoffmann AD
Year: 2014
Journal: PLoS Genet
Title: Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Volume: 10
Issue: 10
Pages: e1004604
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Publication
26193634 | J:224597
First Author: Kramann R
Year: 2015
Journal: J Clin Invest
Title: Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.
Volume: 125
Issue: 8
Pages: 2935-51
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Publication
31142467 | J:275629
 
First Author: Gomez HG
Year: 2019
Journal: Biol Open
Title: Suppressor of Fused regulates the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism.
Volume: 8
Issue: 6
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Publication
31554934 | J:297205
First Author: Martin-Hurtado A
Year: 2019
Journal: Sci Rep
Title: NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
Volume: 9
Issue: 1
Pages: 13896
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Publication
28615245 | J:281864
First Author: Ye H
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: The regulatory 1α subunit of protein kinase A modulates renal cystogenesis.
Volume: 313
Issue: 3
Pages: F677-F686
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Publication
17440069 | J:120949
First Author: Kim Y
Year: 2007
Journal: Cancer Res
Title: Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells.
Volume: 67
Issue: 8
Pages: 3583-93
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Publication
17688467 | J:127020
First Author: Katagiri R
Year: 2007
Journal: Congenit Anom (Kyoto)
Title: Prevention of ochratoxin A-induced neural tube defects by folic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn.
Volume: 47
Issue: 3
Pages: 90-6
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Publication
26451044 | J:227129
First Author: Singh J
Year: 2015
Journal: J Biol Chem
Title: The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
Volume: 290
Issue: 49
Pages: 29663-75
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Publication
28501478 | J:243204
First Author: Han L
Year: 2017
Journal: Dev Biol
Title: Osr1 functions downstream of Hedgehog pathway to regulate foregut development.
Volume: 427
Issue: 1
Pages: 72-83
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Publication
31948942 | J:287290
First Author: Wijaya J
Year: 2020
Journal: Cancer Res
Title: An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.
Volume: 80
Issue: 7
Pages: 1524-1537
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Publication
25552369 | J:316986
First Author: Dhanyamraju PK
Year: 2015
Journal: Mol Cancer Ther
Title: Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway.
Volume: 14
Issue: 3
Pages: 727-39
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Publication
25236574 | J:320209
First Author: de Oliveira Santos D
Year: 2014
Journal: Exp Mol Pathol
Title: Hedgehog signaling pathway mediates tongue tumorigenesis in wild-type mice but not in Gal3-deficient mice.
Volume: 97
Issue: 3
Pages: 332-7
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Publication
38968120 | J:360708
First Author: Yoshida S
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase.
Volume: 121
Issue: 28
Pages: e2320070121
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Protein
Q6XP49
Organism: Mus musculus/domesticus
Length: 780  
Fragment?: false
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Protein
Q0GE24
Organism: Mus musculus/domesticus
Length: 935  
Fragment?: false
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Protein
A2VDF9
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: true
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Publication
17088561 | -
First Author: Wang X
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A subunit of the mediator complex regulates vertebrate neuronal development.
Volume: 103
Issue: 46
Pages: 17284-9
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Publication
18394596 | -
First Author: Shin CH
Year: 2008
Journal: Dev Biol
Title: Multiple roles for Med12 in vertebrate endoderm development.
Volume: 317
Issue: 2
Pages: 467-79
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Protein Domain
IPR019035 | Mediator_Med12
Type: Domain
Description: The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. On recruitment the Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. The Mediator complex is composed of at least 31 subunits: MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The subunits form at least three structurally distinct submodules. The head and the middle modules interact directly with RNA polymerase II, whereas the elongated tail module interacts with gene-specific regulatory proteins. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation.The head module contains: MED6, MED8, MED11, SRB4/MED17, SRB5/MED18, ROX3/MED19, SRB2/MED20 and SRB6/MED22. The middle module contains: MED1, MED4, NUT1/MED5, MED7, CSE2/MED9, NUT2/MED10, SRB7/MED21 and SOH1/MED31. CSE2/MED9 interacts directly with MED4. The tail module contains: MED2, PGD1/MED3, RGR1/MED14, GAL11/MED15 and SIN4/MED16. The CDK8 module contains: MED12, MED13, CCNC and CDK8. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.Med12 is a component of the evolutionarily conserved Mediator complex []. The Med12 subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signaling pathway via its interaction with Gli3 within the Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription [].
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Strain
MGI:2162522 | C3HeB/FeJ x STX/Le-Mc1r<E-so> Gli3<Xt-J> Zeb1<Tw>/J
Attribute String: mutant stock, spontaneous mutation
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Genotype
Genotype
Symbol: Gli1/Gli1 Gli3/Gli3<+>
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ihh/Ihh Tg(Col2a1-cre)3Amc/?
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Hand2/Hand2 Tg(Prrx1-cre)1Cjt/?
Background: involves: 129 * BALB/cJ * C3H/HeJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+> Spop/Spop Tg(Prrx1-cre)1Cjt/?
Background: involves: C3H/HeJ * C57BL/6J * C57BL/6N * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3 Tg(Prrx1-cre)1Cjt/?
Background: involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3 Ptch1/Ptch1
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3<+> Ptch1/Ptch1
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3 Ptch1/Ptch1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli1/Gli1<+> Gli3/Gli3 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S4/SvJaeSor * Black Swiss * C3H/HeJ * Swiss Webster
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Smo/Smo Tg(Prrx1-cre)1Cjt/?
Background: involves: 129X1/SvJ * C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:103575 | Skp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349658 | Cul1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9WTX6
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Protein
Q9WTX5
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Publication
20354137 | J:162345
First Author: Kalogeropoulos M
Year: 2010
Journal: FASEB J
Title: Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes.
Volume: 24
Issue: 8
Pages: 2893-903
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Publication
23110168 | J:192305
First Author: Saqui-Salces M
Year: 2012
Journal: PLoS One
Title: Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.
Volume: 7
Issue: 10
Pages: e48039
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Publication
10564661 | J:155216
 
First Author: Stone DM
Year: 1999
Journal: J Cell Sci
Title: Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.
Volume: 112 ( Pt 23)
Pages: 4437-48
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Publication
9440116 | J:134186
First Author: Yang JT
Year: 1997
Journal: Mol Med
Title: Expression of human GLI in mice results in failure to thrive, early death, and patchy Hirschsprung-like gastrointestinal dilatation.
Volume: 3
Issue: 12
Pages: 826-35
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Publication
22072985 | J:177991
First Author: Leung VY
Year: 2011
Journal: PLoS Genet
Title: SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.
Volume: 7
Issue: 11
Pages: e1002356
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Publication
38251878 | J:360317
 
First Author: Singh S
Year: 2024
Journal: Hepatol Commun
Title: Modulation of canonical Wnt signaling regulates peribiliary mesenchymal identity during homeostasis and injury.
Volume: 8
Issue: 2
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Genotype
Genotype
Symbol: Gli3/Gli3 Fmn1/Fmn1
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Protein
Q8BQM9
Organism: Mus musculus/domesticus
Length: 2157  
Fragment?: false
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Protein
A2AGH6
Organism: Mus musculus/domesticus
Length: 2190  
Fragment?: false
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Protein
A2AGH9
Organism: Mus musculus/domesticus
Length: 2182  
Fragment?: false
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Protein
A2AGH8
Organism: Mus musculus/domesticus
Length: 2157  
Fragment?: false
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Protein
A0A0G2JET8
Organism: Mus musculus/domesticus
Length: 2185  
Fragment?: false
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Protein Coding Gene
MGI:1917497 | Psmd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104880 | Psmb6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916327 | Psmd11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347014 | Psmb3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98858 | Psmd3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105047 | Psmc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914247 | Psmd12
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347006 | Psma6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104883 | Psma3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106054 | Psmc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104885 | Psma2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913663 | Psmd6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914339 | Psmc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1194513 | Psmb5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1096584 | Psmd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104884 | Psmb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107637 | Psmb7
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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Protein Coding Gene
MGI:1913284 | Psmd14
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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