Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
129
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
627
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
703
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
686
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
730
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
698
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
702
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
715
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
430
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
413
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Oehring SC |
Year: |
2012 |
Journal: |
Genome Biol |
Title: |
Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. |
Volume: |
13 |
Issue: |
11 |
Pages: |
R108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pakala SB |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Regulation of NF-κB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis. |
Volume: |
292 |
Issue: |
11 |
Pages: |
4764 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response. |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou J |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression. |
Volume: |
99 |
Issue: |
21 |
Pages: |
13693-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mishra SK |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. |
Volume: |
23 |
Issue: |
25 |
Pages: |
4422-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghanta KS |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response. |
Volume: |
286 |
Issue: |
9 |
Pages: |
7132-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
76
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
98
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
55
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Solari F |
Year: |
1999 |
Journal: |
Development |
Title: |
The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning. |
Volume: |
126 |
Issue: |
11 |
Pages: |
2483-94 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex []. The domain is usually found to the N terminus of a myb-like DNA binding domain and a GATA binding domain. ELM2, in some instances, is also found associated with the ARID DNA binding domain . This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain. |
|
•
•
•
•
•
|
Publication |
First Author: |
Yaguchi M |
Year: |
2005 |
Journal: |
Biochim Biophys Acta |
Title: |
Identification and characterization of the variants of metastasis-associated protein 1 generated following alternative splicing. |
Volume: |
1732 |
Issue: |
1-3 |
Pages: |
8-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Millard CJ |
Year: |
2016 |
Journal: |
Elife |
Title: |
The structure of the core NuRD repression complex provides insights into its interaction with chromatin. |
Volume: |
5 |
|
Pages: |
e13941 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The R1 domain is found in the MTA1 protein and its homologues. The domain is composed of 4 alpha helices. It has been shown to bind to the RBBP4 protein []. The MTA proteins contain a second partial copy of this domain called R2. The R2 domain is matched by this model for some proteins. |
|
•
•
•
•
•
|
Publication |
First Author: |
Toh Y |
Year: |
2009 |
Journal: |
Clin Exp Metastasis |
Title: |
The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications. |
Volume: |
26 |
Issue: |
3 |
Pages: |
215-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
1999 |
Journal: |
Genes Dev |
Title: |
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |
Volume: |
13 |
Issue: |
15 |
Pages: |
1924-35 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
96
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
87
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
195
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
97
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
MTA (metastasis-associated) proteins, including MTA1-3, are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex. Nevertheless, MTA1 and MTA2 have been shown to deacetylate non-histone proteins, such as p53. The expression of MTA proteins have been linked to human cancers [].Mesoderm induction early response proteins (MIER1-3) are ELM2-SANT domain-containing proteins. MIER1 functions as a transcriptional repressor through its ability to recruit HDAC1/2 activity[]. The function of MIER2 and MIER3 is not clear []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Metastasis-associated protein MTA2 is a component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD) []. It is a member of the MTA family.MTA (metastasis-associated) family members, including MTA1-3, are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex. Nevertheless, MTA1 and MTA2 have been shown to deacetylate non-histone proteins, such as p53. The expression of the MTA family members have been linked to human cancers []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen WY |
Year: |
2005 |
Journal: |
Cell |
Title: |
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. |
Volume: |
123 |
Issue: |
3 |
Pages: |
437-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang W |
Year: |
2010 |
Journal: |
Oncogene |
Title: |
A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. |
Volume: |
29 |
Issue: |
17 |
Pages: |
2467-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van Rechem C |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1). |
Volume: |
284 |
Issue: |
31 |
Pages: |
20927-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pinte S |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. |
Volume: |
279 |
Issue: |
37 |
Pages: |
38313-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van Rechem C |
Year: |
2010 |
Journal: |
Mol Cell Biol |
Title: |
Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells. |
Volume: |
30 |
Issue: |
16 |
Pages: |
4045-59 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Hypermethylated in cancer 1 (HIC1) is a transcriptional repressor that modulates P53-dependent and E2F1-dependent cell growth control and is epigenetically inactivated in various human cancers []. It recognises and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' []. It is a direct transcriptional repressor of ephrin-A1 and CXCR7, which are implicated in the pathogenesis of different cancers [, ]. HIC1 is also involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses []. HIC1 interacts with several different corepressors such as CTBP1, CTBP2 and MTA1 (a subunit of the NuRD complex) []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhar S |
Year: |
2017 |
Journal: |
FEBS Lett |
Title: |
MTA1-activated Epi-microRNA-22 regulates E-cadherin and prostate cancer invasiveness. |
Volume: |
591 |
Issue: |
6 |
Pages: |
924-933 |
|
•
•
•
•
•
|
Publication |
First Author: |
Korfanty J |
Year: |
2018 |
Journal: |
Reproduction |
Title: |
SPEN protein expression and interactions with chromatin in mouse testicular cells. |
Volume: |
156 |
Issue: |
3 |
Pages: |
195-206 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
145
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
117
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
148
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Bagheri-Yarmand R |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Metastasis-associated protein 1 transgenic mice: a new model of spontaneous B-cell lymphomas. |
Volume: |
67 |
Issue: |
15 |
Pages: |
7062-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang J |
Year: |
2008 |
Journal: |
Nat Cell Biol |
Title: |
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. |
Volume: |
10 |
Issue: |
6 |
Pages: |
731-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li DQ |
Year: |
2012 |
Journal: |
Cancer Res |
Title: |
Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer. |
Volume: |
72 |
Issue: |
2 |
Pages: |
387-94 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Cuello-Carrión FD |
Year: |
2013 |
Journal: |
Cell Stress Chaperones |
Title: |
In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1-/- alters PTEN and NHERF1 but not β-catenin expression. |
Volume: |
18 |
Issue: |
5 |
Pages: |
559-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bagheri-Yarmand R |
Year: |
2004 |
Journal: |
Development |
Title: |
Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis. |
Volume: |
131 |
Issue: |
14 |
Pages: |
3469-79 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
153
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Derwish R |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Differential HDAC1 and 2 Recruitment by Members of the MIER Family. |
Volume: |
12 |
Issue: |
1 |
Pages: |
e0169338 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
668
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
668
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
521
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
591
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
513
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
580
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
514
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
513
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
514
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
522
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
586
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding Z |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. |
Volume: |
23 |
Issue: |
1 |
Pages: |
250-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
541
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
511
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
551
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
511
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
524
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
271
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
549
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang H |
Year: |
2006 |
Journal: |
Clin Cancer Res |
Title: |
Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. |
Volume: |
12 |
Issue: |
5 |
Pages: |
1479-86 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
480
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
523
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
451
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
479
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
351
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
551
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
382
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
584
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
447
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1010
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1011
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
141
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1558
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1290
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1071
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1089
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1205
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1363
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
733
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
714
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Villén J |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Large-scale phosphorylation analysis of mouse liver. |
Volume: |
104 |
Issue: |
5 |
Pages: |
1488-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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