Type |
Details |
Score |
DO Term |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Torres M |
Year: |
2012 |
Journal: |
Mol Neurodegener |
Title: |
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus. |
Volume: |
7 |
|
Pages: |
59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrano N |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. |
Volume: |
276 |
Issue: |
23 |
Pages: |
19787-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
GavÃn R |
Year: |
2008 |
Journal: |
Neurobiol Dis |
Title: |
Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons. |
Volume: |
30 |
Issue: |
2 |
Pages: |
243-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerber H |
Year: |
2019 |
Journal: |
Acta Neuropathol Commun |
Title: |
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. |
Volume: |
7 |
Issue: |
1 |
Pages: |
13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bjelik A |
Year: |
2006 |
Journal: |
Neurochem Int |
Title: |
Human apoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis. |
Volume: |
49 |
Issue: |
4 |
Pages: |
393-400 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simón AM |
Year: |
2009 |
Journal: |
Neurobiol Dis |
Title: |
Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels. |
Volume: |
33 |
Issue: |
3 |
Pages: |
369-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueda S |
Year: |
2023 |
Journal: |
FASEB J |
Title: |
Acute inhibition of AMPA receptors by perampanel reduces amyloid β-protein levels by suppressing β-cleavage of APP in Alzheimer's disease models. |
Volume: |
37 |
Issue: |
11 |
Pages: |
e23252 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seshadri S |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. |
Volume: |
107 |
Issue: |
12 |
Pages: |
5622-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marques SC |
Year: |
2012 |
Journal: |
Neuroscience |
Title: |
Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice. |
Volume: |
220 |
|
Pages: |
256-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo C |
Year: |
2013 |
Journal: |
Neurobiol Aging |
Title: |
Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease. |
Volume: |
34 |
Issue: |
2 |
Pages: |
562-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2006 |
Journal: |
Behav Brain Res |
Title: |
Learning-memory deficit with aging in APP transgenic mice of Alzheimer's disease and intervention by using tetrahydroxystilbene glucoside. |
Volume: |
173 |
Issue: |
2 |
Pages: |
246-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang FH |
Year: |
2012 |
Journal: |
Eur J Neurosci |
Title: |
Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI. |
Volume: |
36 |
Issue: |
9 |
Pages: |
3165-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rabinovich-Nikitin I |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Beneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice. |
Volume: |
7 |
Issue: |
10 |
Pages: |
e46650 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye H |
Year: |
2010 |
Journal: |
Neurobiol Aging |
Title: |
Activation of large-conductance Ca(2+)-activated K(+) channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 mice. |
Volume: |
31 |
Issue: |
4 |
Pages: |
591-604 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kyriakis JM |
Year: |
1992 |
Journal: |
Nature |
Title: |
Raf-1 activates MAP kinase-kinase. |
Volume: |
358 |
Issue: |
6385 |
Pages: |
417-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nam KN |
Year: |
2018 |
Journal: |
Biochim Biophys Acta |
Title: |
Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice. |
Volume: |
1864 |
Issue: |
1 |
Pages: |
152-161 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pozueta J |
Year: |
2013 |
Journal: |
Nat Commun |
Title: |
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. |
Volume: |
4 |
|
Pages: |
1939 |
|
•
•
•
•
•
|
Publication |
First Author: |
He P |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice. |
Volume: |
23 |
Issue: |
24 |
Pages: |
6512-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dassie E |
Year: |
2013 |
Journal: |
Neurobiol Aging |
Title: |
Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model. |
Volume: |
34 |
Issue: |
5 |
Pages: |
1355-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leissring MA |
Year: |
2003 |
Journal: |
Neuron |
Title: |
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. |
Volume: |
40 |
Issue: |
6 |
Pages: |
1087-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oue H |
Year: |
2013 |
Journal: |
Behav Brain Res |
Title: |
Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice. |
Volume: |
252 |
|
Pages: |
318-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chocron ES |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models. |
Volume: |
8 |
Issue: |
23 |
Pages: |
eabk2252 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen Y |
Year: |
2019 |
Journal: |
Front Cell Neurosci |
Title: |
Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice. |
Volume: |
13 |
|
Pages: |
568 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lakshmana MK |
Year: |
2012 |
Journal: |
FASEB J |
Title: |
Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. |
Volume: |
26 |
Issue: |
5 |
Pages: |
2072-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tampellini D |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. |
Volume: |
29 |
Issue: |
31 |
Pages: |
9704-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rockenstein EM |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. |
Volume: |
270 |
Issue: |
47 |
Pages: |
28257-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao P |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension. |
Volume: |
21 |
Issue: |
13 |
Pages: |
2973-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bahn G |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models. |
Volume: |
116 |
Issue: |
25 |
Pages: |
12516-12523 |
|
•
•
•
•
•
|
Publication |
First Author: |
Szapacs ME |
Year: |
2004 |
Journal: |
Neurobiol Dis |
Title: |
Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1. |
Volume: |
16 |
Issue: |
3 |
Pages: |
572-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2008 |
Journal: |
J Neurochem |
Title: |
Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease. |
Volume: |
107 |
Issue: |
1 |
Pages: |
197-207 |
|
•
•
•
•
•
|
Allele |
Name: |
zinc finger and BTB domain containing 20; transgene insertion 20, Lennart Mucke |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Y |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. |
Volume: |
107 |
Issue: |
4 |
Pages: |
1630-5 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimers disease. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis. |
|
•
•
•
•
•
|
Publication |
First Author: |
Lomoio S |
Year: |
2020 |
Journal: |
Sci Transl Med |
Title: |
Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings. |
Volume: |
12 |
Issue: |
570 |
|
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Robert Vassar |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Colin Dingwall |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Lexicon Genetics |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 2, Lexicon Genetics |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Nobuyuki Nukina |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Paul Saftig |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 2, Paul Saftig |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1.1, Riqiang Yan |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 2, Harwell |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 1, Harwell |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 1, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
DomÃnguez-del-Toro E |
Year: |
2004 |
Journal: |
Eur J Neurosci |
Title: |
An in vitro and in vivo study of early deficits in associative learning in transgenic mice that over-express a mutant form of human APP associated with Alzheimer's disease. |
Volume: |
20 |
Issue: |
7 |
Pages: |
1945-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim N |
Year: |
2020 |
Journal: |
Neurotherapeutics |
Title: |
Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice. |
Volume: |
17 |
Issue: |
1 |
Pages: |
189-199 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 3, Bernd Sommer |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Strecker P |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation. |
Volume: |
6 |
|
Pages: |
25652 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao F |
Year: |
2015 |
Journal: |
Mol Neurodegener |
Title: |
Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model. |
Volume: |
10 |
|
Pages: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beauquis J |
Year: |
2013 |
Journal: |
Exp Neurol |
Title: |
Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease. |
Volume: |
239 |
|
Pages: |
28-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu YC |
Year: |
2021 |
Journal: |
Mol Ther |
Title: |
Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation. |
Volume: |
29 |
Issue: |
1 |
Pages: |
376-395 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maheswaran S |
Year: |
2009 |
Journal: |
Brain Res |
Title: |
Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI. |
Volume: |
1270 |
|
Pages: |
19-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jäckle F |
Year: |
2015 |
Journal: |
Biochem J |
Title: |
Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding. |
Volume: |
470 |
Issue: |
1 |
Pages: |
91-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yanguas-Casás N |
Year: |
2021 |
Journal: |
Neurobiol Dis |
Title: |
High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner. |
Volume: |
159 |
|
Pages: |
105495 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Sannerud R |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. |
Volume: |
108 |
Issue: |
34 |
Pages: |
E559-68 |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen XQ |
Year: |
2023 |
Journal: |
Alzheimers Dement |
Title: |
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. |
Volume: |
19 |
Issue: |
5 |
Pages: |
2095-2116 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ly PT |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes. |
Volume: |
123 |
Issue: |
1 |
Pages: |
224-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qin X |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain. |
Volume: |
291 |
Issue: |
42 |
Pages: |
22276-22287 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Z |
Year: |
2020 |
Journal: |
Cell Death Dis |
Title: |
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice. |
Volume: |
11 |
Issue: |
12 |
Pages: |
1058 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zou K |
Year: |
2013 |
Journal: |
Am J Pathol |
Title: |
Aβ43 is the earliest-depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE. |
Volume: |
182 |
Issue: |
6 |
Pages: |
2322-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sabbagh MN |
Year: |
2008 |
Journal: |
Neurosci Lett |
Title: |
Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind). |
Volume: |
448 |
Issue: |
2 |
Pages: |
217-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
MartÃnez-Drudis L |
Year: |
2024 |
Journal: |
Heliyon |
Title: |
Pharmacological inhibition of PLK2 kinase activity mitigates cognitive decline but aggravates APP pathology in a sex-dependent manner in APP/PS1 mouse model of Alzheimer's disease. |
Volume: |
10 |
Issue: |
20 |
Pages: |
e39571 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao J |
Year: |
1995 |
Journal: |
Brain Res |
Title: |
Chronic elevation of S100 beta protein does not alter APP mRNA expression or promote beta-amyloid deposition in the brains of aging transgenic mice. |
Volume: |
702 |
Issue: |
1-2 |
Pages: |
32-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rutten BP |
Year: |
2003 |
Journal: |
Neurobiol Dis |
Title: |
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment. |
Volume: |
12 |
Issue: |
2 |
Pages: |
110-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mastrangelo P |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. |
Volume: |
102 |
Issue: |
25 |
Pages: |
8972-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
MartÃnez-Mármol R |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model. |
Volume: |
39 |
Issue: |
40 |
Pages: |
7976-7991 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li C |
Year: |
2024 |
Journal: |
Front Neurosci |
Title: |
8-weeks aerobic exercise ameliorates cognitive deficit and mitigates ferroptosis triggered by iron overload in the prefrontal cortex of APP (Swe)/PSEN (1dE9) mice through Xc(-)/GPx4 pathway. |
Volume: |
18 |
|
Pages: |
1453582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brijbassi S |
Year: |
2007 |
Journal: |
Neurobiol Dis |
Title: |
Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo. |
Volume: |
25 |
Issue: |
2 |
Pages: |
291-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou GF |
Year: |
2023 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation. |
Volume: |
120 |
Issue: |
22 |
Pages: |
e2220148120 |
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Publication |
First Author: |
Jiang H |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα. |
Volume: |
23 |
Issue: |
18 |
Pages: |
4906-18 |
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Publication |
First Author: |
Liu Y |
Year: |
2017 |
Journal: |
CNS Neurosci Ther |
Title: |
Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice. |
Volume: |
23 |
Issue: |
7 |
Pages: |
590-604 |
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•
•
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•
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Publication |
First Author: |
Okada H |
Year: |
2010 |
Journal: |
FASEB J |
Title: |
Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. |
Volume: |
24 |
Issue: |
8 |
Pages: |
2783-94 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
674
 |
Fragment?: |
false |
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•
•
•
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Allele |
Name: |
transgene insertion 46, Laurent Pradier |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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•
•
•
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Interaction Experiment |
Description: |
Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by ?- or ?-Secretase Cleavage. |
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•
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Genotype |
Symbol: |
Appd1/Appd1 Tg(APPSWE)2576Kha/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * FVB/NCr * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Genotype |
Symbol: |
Appd2/Appd2 Tg(APPSWE)2576Kha/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * FVB/NCr * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
•
•
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GO Term |
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•
•
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Publication |
First Author: |
Barão S |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse. |
Volume: |
12 |
Issue: |
9 |
Pages: |
1367-76 |
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•
•
•
•
•
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Publication |
First Author: |
Miyagawa T |
Year: |
2016 |
Journal: |
Hum Mol Genet |
Title: |
BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. |
Volume: |
25 |
Issue: |
14 |
Pages: |
2948-2958 |
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•
•
•
•
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Publication |
First Author: |
Jonas MC |
Year: |
2008 |
Journal: |
EMBO Rep |
Title: |
PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1. |
Volume: |
9 |
Issue: |
9 |
Pages: |
916-22 |
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•
•
•
•
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Publication |
First Author: |
Perdigão C |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling. |
Volume: |
297 |
Issue: |
3 |
Pages: |
101056 |
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•
•
•
•
•
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Publication |
First Author: |
Parr C |
Year: |
2015 |
Journal: |
FASEB J |
Title: |
Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter. |
Volume: |
29 |
Issue: |
2 |
Pages: |
623-35 |
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•
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•
•
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Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Steven L Roberds |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
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•
•
•
•
•
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Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1.1, Steven L Roberds |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 2, Steven L Roberds |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
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•
•
•
•
•
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Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Philip C Wong |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1, Joseph D Buxbaum |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
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Strain |
Attribute String: |
mutant stock, targeted mutation |
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Allele |
Name: |
beta-site APP cleaving enzyme 1; gene trap G034G06, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
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Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
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•
•
•
•
•
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Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
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•
•
•
•
•
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Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
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•
•
•
•
•
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Allele |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
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•
•
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•
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