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Search results 2001 to 2100 out of 7122 for App

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Type Details Score
DO Term
Transgene
Type: transgene
Organism: mouse, laboratory
Publication  
First Author: Torres M
Year: 2012
Journal: Mol Neurodegener
Title: Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Volume: 7
Pages: 59
Publication
First Author: Zambrano N
Year: 2001
Journal: J Biol Chem
Title: The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.
Volume: 276
Issue: 23
Pages: 19787-92
Publication
First Author: Gavín R
Year: 2008
Journal: Neurobiol Dis
Title: Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons.
Volume: 30
Issue: 2
Pages: 243-54
Publication
First Author: Gerber H
Year: 2019
Journal: Acta Neuropathol Commun
Title: The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.
Volume: 7
Issue: 1
Pages: 13
Publication
First Author: Bjelik A
Year: 2006
Journal: Neurochem Int
Title: Human apoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis.
Volume: 49
Issue: 4
Pages: 393-400
Publication
First Author: Simón AM
Year: 2009
Journal: Neurobiol Dis
Title: Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.
Volume: 33
Issue: 3
Pages: 369-78
Publication
First Author: Ueda S
Year: 2023
Journal: FASEB J
Title: Acute inhibition of AMPA receptors by perampanel reduces amyloid β-protein levels by suppressing β-cleavage of APP in Alzheimer's disease models.
Volume: 37
Issue: 11
Pages: e23252
Publication
First Author: Seshadri S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade.
Volume: 107
Issue: 12
Pages: 5622-7
Publication  
First Author: Marques SC
Year: 2012
Journal: Neuroscience
Title: Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice.
Volume: 220
Pages: 256-66
Publication
First Author: Guo C
Year: 2013
Journal: Neurobiol Aging
Title: Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease.
Volume: 34
Issue: 2
Pages: 562-75
Publication
First Author: Zhang L
Year: 2006
Journal: Behav Brain Res
Title: Learning-memory deficit with aging in APP transgenic mice of Alzheimer's disease and intervention by using tetrahydroxystilbene glucoside.
Volume: 173
Issue: 2
Pages: 246-54
Publication
First Author: Wang FH
Year: 2012
Journal: Eur J Neurosci
Title: Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI.
Volume: 36
Issue: 9
Pages: 3165-72
Publication
First Author: Rabinovich-Nikitin I
Year: 2012
Journal: PLoS One
Title: Beneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice.
Volume: 7
Issue: 10
Pages: e46650
Publication
First Author: Ye H
Year: 2010
Journal: Neurobiol Aging
Title: Activation of large-conductance Ca(2+)-activated K(+) channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 mice.
Volume: 31
Issue: 4
Pages: 591-604
Publication
First Author: Kyriakis JM
Year: 1992
Journal: Nature
Title: Raf-1 activates MAP kinase-kinase.
Volume: 358
Issue: 6385
Pages: 417-21
Publication
First Author: Nam KN
Year: 2018
Journal: Biochim Biophys Acta
Title: Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.
Volume: 1864
Issue: 1
Pages: 152-161
Publication  
First Author: Pozueta J
Year: 2013
Journal: Nat Commun
Title: Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.
Volume: 4
Pages: 1939
Publication
First Author: He P
Year: 2014
Journal: Hum Mol Genet
Title: Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice.
Volume: 23
Issue: 24
Pages: 6512-27
Publication
First Author: Dassie E
Year: 2013
Journal: Neurobiol Aging
Title: Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model.
Volume: 34
Issue: 5
Pages: 1355-68
Publication
First Author: Leissring MA
Year: 2003
Journal: Neuron
Title: Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.
Volume: 40
Issue: 6
Pages: 1087-93
Publication  
First Author: Oue H
Year: 2013
Journal: Behav Brain Res
Title: Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice.
Volume: 252
Pages: 318-25
Publication
First Author: Chocron ES
Year: 2022
Journal: Sci Adv
Title: Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models.
Volume: 8
Issue: 23
Pages: eabk2252
Publication  
First Author: Shen Y
Year: 2019
Journal: Front Cell Neurosci
Title: Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.
Volume: 13
Pages: 568
Publication
First Author: Lakshmana MK
Year: 2012
Journal: FASEB J
Title: Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain.
Volume: 26
Issue: 5
Pages: 2072-83
Publication
First Author: Tampellini D
Year: 2009
Journal: J Neurosci
Title: Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.
Volume: 29
Issue: 31
Pages: 9704-13
Publication
First Author: Rockenstein EM
Year: 1995
Journal: J Biol Chem
Title: Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease.
Volume: 270
Issue: 47
Pages: 28257-67
Publication
First Author: Mao P
Year: 2012
Journal: Hum Mol Genet
Title: Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.
Volume: 21
Issue: 13
Pages: 2973-90
Publication
First Author: Bahn G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.
Volume: 116
Issue: 25
Pages: 12516-12523
Publication
First Author: Szapacs ME
Year: 2004
Journal: Neurobiol Dis
Title: Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1.
Volume: 16
Issue: 3
Pages: 572-80
Publication
First Author: Chen L
Year: 2008
Journal: J Neurochem
Title: Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease.
Volume: 107
Issue: 1
Pages: 197-207
Allele
Name: zinc finger and BTB domain containing 20; transgene insertion 20, Lennart Mucke
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication
First Author: Jiang Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.
Volume: 107
Issue: 4
Pages: 1630-5
Interaction Experiment
Description: The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimers disease.
Interaction Experiment
Description: APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis.
Publication  
First Author: Lomoio S
Year: 2020
Journal: Sci Transl Med
Title: Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings.
Volume: 12
Issue: 570
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Robert Vassar
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Colin Dingwall
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Lexicon Genetics
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 2, Lexicon Genetics
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Nobuyuki Nukina
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Paul Saftig
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 2, Paul Saftig
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1.1, Riqiang Yan
Allele Type: Targeted
Attribute String: Conditional ready
Allele
Name: beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 2, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 1, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Domínguez-del-Toro E
Year: 2004
Journal: Eur J Neurosci
Title: An in vitro and in vivo study of early deficits in associative learning in transgenic mice that over-express a mutant form of human APP associated with Alzheimer's disease.
Volume: 20
Issue: 7
Pages: 1945-52
Publication
First Author: Kim N
Year: 2020
Journal: Neurotherapeutics
Title: Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice.
Volume: 17
Issue: 1
Pages: 189-199
Allele
Name: transgene insertion 3, Bernd Sommer
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication  
First Author: Strecker P
Year: 2016
Journal: Sci Rep
Title: FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.
Volume: 6
Pages: 25652
Publication  
First Author: Liao F
Year: 2015
Journal: Mol Neurodegener
Title: Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.
Volume: 10
Pages: 12
Publication  
First Author: Beauquis J
Year: 2013
Journal: Exp Neurol
Title: Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease.
Volume: 239
Pages: 28-37
Publication
First Author: Liu YC
Year: 2021
Journal: Mol Ther
Title: Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation.
Volume: 29
Issue: 1
Pages: 376-395
Publication  
First Author: Maheswaran S
Year: 2009
Journal: Brain Res
Title: Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI.
Volume: 1270
Pages: 19-32
Publication
First Author: Jäckle F
Year: 2015
Journal: Biochem J
Title: Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
Volume: 470
Issue: 1
Pages: 91-103
Publication  
First Author: Yanguas-Casás N
Year: 2021
Journal: Neurobiol Dis
Title: High-fat diet alters stress behavior, inflammatory parameters and gut microbiota in Tg APP mice in a sex-specific manner.
Volume: 159
Pages: 105495
GO Term
Publication
First Author: Sannerud R
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.
Volume: 108
Issue: 34
Pages: E559-68
Transgene
Type: transgene
Organism: mouse, laboratory
Publication
First Author: Chen XQ
Year: 2023
Journal: Alzheimers Dement
Title: Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.
Volume: 19
Issue: 5
Pages: 2095-2116
Publication
First Author: Ly PT
Year: 2013
Journal: J Clin Invest
Title: Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.
Volume: 123
Issue: 1
Pages: 224-35
Publication
First Author: Qin X
Year: 2016
Journal: J Biol Chem
Title: Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain.
Volume: 291
Issue: 42
Pages: 22276-22287
Publication
First Author: Wu Z
Year: 2020
Journal: Cell Death Dis
Title: Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Volume: 11
Issue: 12
Pages: 1058
Publication
First Author: Zou K
Year: 2013
Journal: Am J Pathol
Title: Aβ43 is the earliest-depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE.
Volume: 182
Issue: 6
Pages: 2322-31
Publication
First Author: Sabbagh MN
Year: 2008
Journal: Neurosci Lett
Title: Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind).
Volume: 448
Issue: 2
Pages: 217-20
Publication
First Author: Martínez-Drudis L
Year: 2024
Journal: Heliyon
Title: Pharmacological inhibition of PLK2 kinase activity mitigates cognitive decline but aggravates APP pathology in a sex-dependent manner in APP/PS1 mouse model of Alzheimer's disease.
Volume: 10
Issue: 20
Pages: e39571
Publication
First Author: Yao J
Year: 1995
Journal: Brain Res
Title: Chronic elevation of S100 beta protein does not alter APP mRNA expression or promote beta-amyloid deposition in the brains of aging transgenic mice.
Volume: 702
Issue: 1-2
Pages: 32-6
Publication
First Author: Rutten BP
Year: 2003
Journal: Neurobiol Dis
Title: No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.
Volume: 12
Issue: 2
Pages: 110-20
Publication
First Author: Mastrangelo P
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Volume: 102
Issue: 25
Pages: 8972-7
Publication
First Author: Martínez-Mármol R
Year: 2019
Journal: J Neurosci
Title: p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model.
Volume: 39
Issue: 40
Pages: 7976-7991
Publication  
First Author: Li C
Year: 2024
Journal: Front Neurosci
Title: 8-weeks aerobic exercise ameliorates cognitive deficit and mitigates ferroptosis triggered by iron overload in the prefrontal cortex of APP (Swe)/PSEN (1dE9) mice through Xc(-)/GPx4 pathway.
Volume: 18
Pages: 1453582
Publication
First Author: Brijbassi S
Year: 2007
Journal: Neurobiol Dis
Title: Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
Volume: 25
Issue: 2
Pages: 291-6
Publication
First Author: Zhou GF
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
Volume: 120
Issue: 22
Pages: e2220148120
Publication
First Author: Jiang H
Year: 2014
Journal: Hum Mol Genet
Title: Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.
Volume: 23
Issue: 18
Pages: 4906-18
Publication
First Author: Liu Y
Year: 2017
Journal: CNS Neurosci Ther
Title: Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice.
Volume: 23
Issue: 7
Pages: 590-604
Publication
First Author: Okada H
Year: 2010
Journal: FASEB J
Title: Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.
Volume: 24
Issue: 8
Pages: 2783-94
Protein
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: false
Allele
Name: transgene insertion 46, Laurent Pradier
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Interaction Experiment
Description: Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by ?- or ?-Secretase Cleavage.
Genotype
Symbol: Appd1/Appd1 Tg(APPSWE)2576Kha/?
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NCr * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Appd2/Appd2 Tg(APPSWE)2576Kha/?
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NCr * SJL
Zygosity: cx
Has Mutant Allele: true
GO Term
Publication
First Author: Barão S
Year: 2015
Journal: Cell Rep
Title: Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.
Volume: 12
Issue: 9
Pages: 1367-76
Publication
First Author: Miyagawa T
Year: 2016
Journal: Hum Mol Genet
Title: BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
Volume: 25
Issue: 14
Pages: 2948-2958
Publication
First Author: Jonas MC
Year: 2008
Journal: EMBO Rep
Title: PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.
Volume: 9
Issue: 9
Pages: 916-22
Publication
First Author: Perdigão C
Year: 2021
Journal: J Biol Chem
Title: Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling.
Volume: 297
Issue: 3
Pages: 101056
Publication
First Author: Parr C
Year: 2015
Journal: FASEB J
Title: Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter.
Volume: 29
Issue: 2
Pages: 623-35
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Steven L Roberds
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1.1, Steven L Roberds
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 2, Steven L Roberds
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Philip C Wong
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Joseph D Buxbaum
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Strain
Attribute String: mutant stock, targeted mutation
Allele  
Name: beta-site APP cleaving enzyme 1; gene trap G034G06, German Gene Trap Consortium
Allele Type: Gene trapped
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Allele
Name: beta-site APP cleaving enzyme 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready